Dihydrohonokiol (DHH-B) is a natural compound
extracted from magnolia bark, known for its anxiolytic
effects. It promotes a sense of calm without causing
motor dysfunction, amnesia, or physical dependence.
Unlike synthetic drugs, DHH-B doesn’t exacerbate side
effects or lead to withdrawal symptoms.

As a potent form of honokiol, it offers a
natural alternative for anxiety and stress
management.

Cellular Pathways

Chronic administration of honokiol, a natural
compound, results in the buildup of a metabolite called
dihydrohonokiol-B (DHH-B), which is responsible for
honokiol’s anxiolytic (anxiety-reducing) effects. DHH-B
acts as a potent agent to reduce anxiety by targeting
the GABA_A receptor-gated chloride channel complex
in the brain, suggesting a specific mechanism through
which DHH-B can alleviate anxiety.

Why this matters:

Magnolia bark and its extracts need to be administered repeatedly to achieve their effects, whereas DHH-B (dihydrohonokiol-B) provides immediate anxiety-reducing benefits. Unlike benzodiazepines, a common class of anxiolytics, DHH-B does not lead to motor dysfunction or dependency. This underlines DHH-B’s promise as a therapeutic option for anxiety disorders, showcasing its capacity to alter neurotransmitter systems for effective anxiolytic outcomes without the significant side effects associated with many traditional medications.

Clinical Studies

Honokiol, a putative anxiolytic agent extracted from magnolia bark, 
has no diazepam-like side-effects in mice

•     Anxiety reducing effects without affecting motor activity or muscle tone
•     Honokiol did not exhibit withdrawal symptoms seen with benzodiazepines
•     Honokiol did not disrupt learning, memory or central nervous system depression at anxiolytic doses

Synergy with Oxytocin, Sermorelin, GLP-1:

DHH-B + Oxytocin

Oxytocin has been shown to decrease stress by its ability to reduce cortisol while DHH-B also has an anxiolytic effect by stimulating gaba receptors and manage stress and anxiety.

DHH-B + Sermorelin

DHH-B helps patients manage sleep patterns. Typcially used with Sermorelin which improves night time growth hormone secretion that has been shown to enhance deep sleep.

DHH-B + GLP-1

Cortisol has been shown to be anabolic to fat tissue and catabolic to muscle tissue putting effective weight loss on hold. The combination of GLP-1 with DHH-B has been used to mitigate stress induced weight loss resistance.

Ingredients