Probiotics

MegaSporeBiotic™ – 100% Spore-Based Probiotic for Gut Reconditioning, Capsules

Microbiome Labs

Clinically Proven. Spore-Powered. Microbiome Reconditioning Starts Here.

MegaSporeBiotic™ is the first clinically studied, 100% spore-based probiotic supplement designed to recondition the gut microbiome, support gut barrier integrity, and promote immune homeostasis. Unlike conventional probiotics that often die before reaching the intestines, spore-forming Bacillus strains in MegaSporeBiotic™ are naturally equipped to survive digestion, colonize the gut, and restore microbial balance.

This flagship product of Microbiome Labs is shelf-stable, effective at a low dose (4 Billion CFU), and does not require refrigeration.

Key Benefits

• Clinically shown to recondition the gut and support microbial diversity

• Promotes gut lining repair and intestinal barrier integrity

• Supports immune modulation and inflammatory balance

• Enhances production of short-chain fatty acids (SCFAs), especially butyrate

• Helps maintain levels of beneficial commensal bacteria

• Survives heat, stomach acid, and bile — no refrigeration needed

• Part of the Total Gut Restoration system by Microbiome Labs

Science Behind the Strains

Each 2-capsule serving delivers 4 Billion CFU of five synergistic, spore-forming Bacillus strains:

• Bacillus indicus HU36™ – Produces antioxidants (lycopene, astaxanthin, beta-carotene) at the site of absorption

• Bacillus subtilis HU58™ – Supports immune modulation, gut lining, and vitamin K2 production

• Bacillus coagulans SC208 – Enhances protein digestion and metabolic support

• Bacillus licheniformis SL307 – Promotes mucosal immunity and digestive balance

• Bacillus clausii SC109 – Resistant to antibiotics; helps regulate immune and respiratory health

These strains are clinically validated and selected for their ability to support keystone gut species and SCFA production — both essential for optimal health.

Supplement Facts

Serving Size: 2 capsules
Servings Per Container: 30
Probiotic Content: 4 Billion CFU
Total Active Blend: 295 mg

Other Ingredients: Cellulose, vegetable capsule (cellulose and water)
Free from: dairy, gluten, soy, GMOs, artificial colors or preservatives

Suggested Use

Ages 5+:

• Week 1: Take 1 capsule every other day

• Week 2: Take 1 capsule daily

• Week 3 onward: Take 2 capsules daily

Children under 5: Use only under medical supervision.
Can be taken with or without food. No refrigeration required.

Frequently Asked Questions (FAQ)

Q: What makes MegaSporeBiotic™ different from regular probiotics?
A: It contains only spore-based Bacillus strains, which survive digestion, colonize the gut, and recondition the microbiome — unlike typical Lactobacillus or Bifidobacterium strains that often degrade in the stomach.

Q: Is 4 Billion CFU enough?
A: Yes. Spore-based probiotics are highly potent. Clinical trials show 4 Billion CFU is effective for gut restoration and immune modulation.

Q: Can I take it with antibiotics?
A: Yes. Unlike many probiotics, Bacillus spores are resistant to most antibiotics, making this an excellent companion during or after antibiotic use.

Q: Should I take this with food?
A: It can be taken with or without food, but some people prefer taking it with meals for better tolerance during the initial adjustment period.

MegaPre™ – Precision Prebiotic Powder, 5.5 oz (144.5 g)

Microbiome Labs

Clinically Targeted Prebiotic to Restore Keystone Gut Bacteria

MegaPre™ is a cutting-edge Precision Prebiotic™ powder that selectively nourishes beneficial gut bacteria — without feeding opportunistic microbes. Unlike general fiber products, MegaPre™ contains clinically tested oligosaccharides and organic kiwifruit powder that promote the growth of keystone species like Akkermansia muciniphila, Faecalibacterium prausnitzii, and Bifidobacteria. These bacteria play a foundational role in gut barrier integrity, immune regulation, and short-chain fatty acid (SCFA) production.

This 5.5 oz jar contains 30 servings of unflavored, mixable powder — ideal for daily gut support and easy integration into Total Gut Restoration protocols.

Key Benefits

• Selectively feeds critical keystone bacteria (not broad-spectrum)

• Enhances microbial diversity and butyrate production

• Supports healthy gut lining and mucosal immunity

• Works synergistically with MegaSporeBiotic™

• Easy-to-mix, unflavored formula for customizable use

• Gluten-free, non-GMO, no artificial ingredients

Science Behind MegaPre™

Keystone species are essential for gut health, but modern lifestyles (processed foods, antibiotics, stress) often deplete them. MegaPre™ helps rebuild this foundation through a proprietary blend of:

• Galactooligosaccharides (Bimuno®) – Shown to support Bifidobacteria and enhance SCFA production

• Xylooligosaccharides (PreticX®) – Clinically proven to improve microbial diversity and support bowel regularity

• Organic Kiwifruit Powder (Livaux® and ACTAZIN®) – Rich in polyphenols and fiber to support gut motility and microbial balance

Together, these ingredients provide targeted nourishment for the microbiome — without causing bloating or feeding unwanted bacteria.

Supplement Facts

Serving Size: 1 scoop (4.8 g)
Servings Per Container: 30
Net Weight: 5.5 oz (144.6 g)

Other Ingredients:
None. Unflavored. Free of sweeteners, colors, and artificial additives.
Contains: milk (from lactose-derived GOS).
(Dairy-free version available separately.)

Suggested Use

Ages 4 and up:

• Start with ½ scoop per day during the first week

• Increase to 1 scoop daily, or as directed by your healthcare provider

• Mix into 8–12 oz of room temperature water, smoothie, or non-hot liquid

Children under 4: Use only under medical supervision.

Frequently Asked Questions (FAQ)

Q: Is MegaPre™ a fiber supplement?
A: Not exactly. While it contains fiber, it's a targeted prebiotic designed to support specific beneficial microbes rather than general digestion.

Q: What does it taste like?
A: It’s unflavored and mixes well with water, smoothies, or juice. No sweetness or added flavor.

Q: Can I take it with MegaSporeBiotic™?
A: Yes. It’s highly recommended as part of Microbiome Labs’ Total Gut Restoration protocol, supporting long-term microbial shifts.

Q: Is it suitable for people with sensitive digestion?
A: Yes. MegaPre™ is well-tolerated, even in individuals who react poorly to traditional prebiotics. Start with a half dose to assess tolerance.

RestorFlora™ – Comprehensive Gut Recovery Probiotic with Yeast & Spore-Based Bacteria, 60 Capsules

Microbiome Labs

Advanced Multi-Strain Formula for Digestive & Immune Resilience

RestorFlora™ is a broad-spectrum probiotic and gut recovery formula combining a clinically validated probiotic yeast (Saccharomyces boulardii) with three resilient spore-forming bacterial strains: Bacillus subtilis HU58™, Bacillus clausii SC-109, and Bacillus coagulans SC208. This powerful combination is designed to restore microbial balance, promote gut resilience, and support digestion and immunity — even during or after gut-disruptive events like antibiotics, food poisoning, or GI stress.

Unlike traditional probiotics that may degrade in the stomach or fail under antibiotic pressure, RestorFlora™ delivers hardy, shelf-stable strains that survive transit, colonize the gut, and maintain immune synergy.

Key Benefits

• Supports intestinal flora balance and microbiome resilience

• Helps maintain digestive comfort and motility

• Supports healthy transit time and relief from bloating, gas, cramps, diarrhea, or constipation

• Promotes gut recovery during/after gut-disrupting medications or practices

• Enhances immune system response and gut-lining integrity

• Combines yeast and bacterial strains for broader-spectrum support

• Shelf-stable, dairy-free, gluten-free, soy-free

Unique Multi-Strain Composition

Each capsule delivers a clinically studied combination of:

🦠 Saccharomyces boulardii (CNCM I-1079)

• A probiotic yeast known for use during and after antibiotic therapy

• Helps maintain intestinal barrier function and prevent overgrowth of unwanted microbes

• Extensively used to reduce the risk of antibiotic-associated diarrhea

🦠 Bacillus subtilis HU58™

• Spore-forming probiotic that resists stomach acid, activates in the intestines

• Produces key nutrients like vitamin K2 and short-chain fatty acids (SCFAs)

• Supports mucosal immunity and gut lining regeneration

🦠 Bacillus clausii (SC-109)

• Naturally antibiotic-resistant

• Helps regulate immune balance and support respiratory health

• Known to persist and colonize even under antimicrobial pressure

🦠 Bacillus coagulans (SC208)

• Assists protein digestion and carbohydrate fermentation

• Produces lactic acid to modulate gut pH

• Improves symptoms like bloating and abdominal discomfort

Supplement Facts

Serving Size: 1 capsule
Servings Per Container: 60
Probiotic Blend Total: 370 mg / 8 Billion CFU

MegaGuard™ is a novel digestive aid that combines licorice polyphenols, cleansing artichoke leaf extract, and soothing ginger to promote normal digestion, regulate stomach acid, maintain healthy H. pylori levels, and reduce occasional digestive discomforts such as gas and bloating. With the power of these herbs combined, MegaGuard™️ provides unique and comprehensive digestive support, bowel regularity, and gastric balance.*
Suggested Use: Ages 8+: Take one capsule with lunch and dinner, or as directed by your healthcare practitioner.

Serving Size: 1 Capsule 

Amount Per Serving
Artichoke leaf extract ... 320mg
Gutgard® licorice flavonoids ... 75mg
Ginger root extract ... 30mg
(20% gingerols)

Other Ingredients: Cellulose, vegetable capsule (water and cellulose).
If you are pregnant or nursing; taking any medication; have a medical condition, consult your doctor before using this product.  Keep out of reach of children.  Do not use if safety seal is broken or missing.

Enzyme combination to disrupt biofilm matrix

Benefits and Features

• In vitro testing demonstrates significant anti-biofilm activity^†
• Helps degrading bacterial and yeast cell wall structures^†
• Encourages healthy intestinal microbial communities^†

Biofilms are protective encasements formed by microorganisms making them highly resistant to antimicrobials. Ther-Biotic® InterFase^® is a unique enzyme formulation designed to break up the biofilm matrix that embeds the GI organisms.^†

Detail Overview

Biofilm consists of microorganisms encased within a self-produced matrix of exopolysaccharides and exoproteins that strongly adheres to interfaces and resists dislodgement. Microorganisms residing within biofilms are highly resistant to antimicrobials including antibiotics and bacteriocins produced by probiotics. Ther-Biotic® InterFase^® is a unique enzyme formulation that is specially designed to disrupt the biofilm matrix that embeds gastrointestinal organisms.^† Enzymes in Ther-Biotic® InterFase^® are selected for their ability to lyse the extracellular polymers commonly found in biofilm as well as degrade bacterial and yeast cell wall structures.^† The enzyme blend in Ther-Biotic® InterFase^® was developed using in vitro testing of antibiofilm activity and was found to have significant antibiofilm activity resulting in meaningful degradation of undesirable biofilm communities.^† Ther-Biotic® InterFase^® is intended for use in conjunction with efforts to support normal gastrointestinal function and microbiota.^† As an adjunct, it is best combined with the use of a high-strength, broad-spectrum, multispecies probiotic formulation and a prebiotic to encourage the formation of healthy intestinal microbial biofilm communities.^†

The capsules should be taken away from meals to maximize the enzyme effects.

SUPPLEMENT FACTS

Synergistic, high CFU microbiota support from 7 probiotics plus a low FODMAP Certified™ prebiotic

Benefits and Features

• Supports healthy digestion, respiratory function, and immune health^†
• Contains Sunfiber®, a Low FODMAP Certified™ prebiotic
• 7 Probiotics plus a low-FODMAP Certified™ prebiotic working together to seed and feed your gut bacteria^†
• Room temperature stable—great for traveling
• 50 Billion CFU

Ther-Biotic® Synbiotic is specially formulated to address unique GI requirements, ensuring comprehensive microbiome, respiratory, and immune support that’s suitable for any individual, from the healthiest to those with sensitivities.^†

Detail Overview

The human microbiome influences many factors required for health and well-being, including metabolic function, gastrointestinal (GI) barrier health, immunologic activities, and neurobehavioral balance. As research surrounding probiotic supplementation continues to develop, there is a growing body of evidence that supports the importance of the supplementation of prebiotics, the non-digestible fibers that provide the essential nourishment needed for healthy flora to survive and successfully colonize the GI tract. By feeding beneficial microbiota, prebiotics contribute to dynamic balance within the GI tract and, subsequently, throughout the body. Now, research has demonstrated that the combination of probiotics with a prebiotic may offer a more profound effect on GI ecology than probiotics alone.

SUPPLEMENT FACTS

Comprehensive microbiome support

Benefits and Features

• The Original Hypoallergenic Probiotic
• Supports both innate and acquired immunity^†
• Helps strengthen intestinal epithelial barrier integrity^†
• Competitive and antagonistic activity against undesirable microorganisms^†
• Short-chain fatty acid production nourishes enterocytes^†
• Healthy inflammation modulation^†
• Maximum probiotic support with colonizing and transient strains
• InTactic® technology to protect probiotics from stomach acid and digestive enzymes

With 12 probiotic species each selected for researched health benefits, Ther-Biotic® Complete is the original doctor-recommended broad-spectrum daily probiotic blend providing 25 Billion CFU.

Detail Overview

Ther-Biotic® Complete is a robust, broad-spectrum, hypoallergenic blend of 12 probiotic species in a base of inulin. Designed to supply a complete spectrum of synergistic and complementary species, each capsule provides 25 billion CFU protected by our proprietary InTactic® technology for maximum viability throughout the intestinal tract.

SUPPLEMENT FACTS