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6 products
MegaMucosa™ – Mucosal Barrier & Immune Support Powder, 150 g
Berry Acai Flavored
Microbiome Labs
Rebuild the Mucosal Barrier. Restore Immune Balance.
MegaMucosa™ is the first gut supplement of its kind — formulated specifically to rebuild and reinforce the intestinal mucosal barrier, a key structural and immune component of gut health. This unique powder combines serum-derived immunoglobulins, four key amino acids, and MicrobiomeX®, a clinically studied citrus bioflavonoid complex that promotes gut microbial diversity and short-chain fatty acid (SCFA) production.
Ideal for individuals with intestinal inflammation, compromised gut lining (“leaky gut”), or undergoing gut restoration protocols, MegaMucosa™ delivers essential building blocks to restore mucosal integrity and regulate immune response within the gastrointestinal tract.
Key Benefits
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Supports regeneration of the gut’s protective mucin layer
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Promotes gut barrier function and epithelial resilience
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Enhances microbial diversity and SCFA production
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Supports mucosal immune function (70% of immunity resides in the gut lining)
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Naturally flavored with berry acai, easy to mix and tolerate
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Dairy-free, casein-free, gluten-free
Science Behind MegaMucosa™
The intestinal mucosa is the first line of immune and structural defense in the gut. It's where microbes, food particles, and immune cells interact — and it's where dysfunction often begins. MegaMucosa™ addresses this critical interface by combining:
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Serum-derived immunoglobulins (ImmunoLin®) – Helps neutralize antigens, toxins, and microbial byproducts in the gut lumen, supporting immune modulation and detoxification.
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Amino Acids (L-proline, L-serine, L-threonine, L-cysteine) – Essential for mucin production and repair of epithelial cells lining the gut.
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MicrobiomeX® (Citrus bioflavonoids) – A patented blend shown to increase SCFA production and support microbial diversity and gut barrier strength.
Together, these ingredients form a foundational formula for rebuilding the mucosal layer, supporting immune function, and restoring long-term gut resilience.
Supplement Facts
Serving Size: 1 scoop (4.8 g)
Servings Per Container: 30
| Nutrient | Amount per Serving |
|---|---|
| L-Proline | 1 g |
| L-Serine | 700 mg |
| L-Threonine | 600 mg |
| L-Cysteine | 500 mg |
| Serum-derived immunoglobulin concentrate (ImmunoLin®) | 1 g |
| — of which IgG | 450 mg |
| Citrus bioflavonoids (MicrobiomeX®) | 80 mg |
| Calories | 15 |
| Total Carbohydrate | 1 g |
| Protein | 1 g |
| Sodium | 20 mg |
Other Ingredients:
Natural berry acai flavor, citric acid, stevia, malic acid, natural flavor, rebaudioside M.
Suggested Use
Ages 4 and up:
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Start with ½ scoop daily for 1 week
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Then increase to 1 scoop daily, with or without food, or as directed by your healthcare practitioner
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Mix with 16 oz or more of liquid (room temperature preferred) or into food
Children under age 4: Use only under medical supervision.
Frequently Asked Questions (FAQ)
Q: What’s the difference between MegaMucosa™ and a probiotic?
A: MegaMucosa™ doesn’t introduce new microbes — instead, it supports the physical and immune environment (the mucosal lining) where microbes live and interact with the body.
Q: Can this help with “leaky gut”?
A: Yes. The mucosal barrier is a core component of the gut lining. MegaMucosa™ provides structural nutrients to restore that barrier and reduce permeability.
Q: What does it taste like?
A: Berry acai — naturally flavored and sweetened with stevia and rebaudioside M. Most users find it pleasant and easy to mix.
Q: Can I combine it with MegaSporeBiotic™ or Mega IgG2000™?
A: Absolutely. MegaMucosa™ is part of the Microbiome Labs Total Gut Restoration protocol and is designed to work synergistically with these formulas.
Mega IgG2000™ – Advanced Immunoglobulin Support, 120 Capsules
Dairy-Free Gut and Immune System Defense
Mega IgG2000™ is a clinically studied, dairy-free immunoglobulin supplement derived from bovine serum, not colostrum. This advanced formula supports immune resilience, digestive health, and gut barrier integrity. By delivering a concentrated source of IgG, IgM, and IgA antibodies, it provides passive immune protection that helps neutralize toxins, pathogens, and inflammatory triggers within the gut.
Unlike milk-derived products, Mega IgG2000™ is free from lactose, casein, and β-lactoglobulin, making it a suitable option for those with dairy sensitivities.
Key Benefits
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Supports gut barrier integrity and mucosal immune function
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Helps neutralize LPS (lipopolysaccharides) and other endotoxins
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Promotes healthy detoxification within the GI tract
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Enhances immune system modulation without overstimulation
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Supports nutrient digestion and absorption
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Lactose-free, casein-free, and β-lactoglobulin-free
Science Behind Mega IgG2000™
Immunoglobulins are antibodies that bind to unwanted microbes and toxins in the gut, helping the body remove them safely before they can trigger immune responses. Mega IgG2000™ contains high concentrations of the three most essential types:
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IgG (Immunoglobulin G) – The most abundant antibody in the human body, responsible for long-term immune surveillance.
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IgM (Immunoglobulin M) – The first antibody produced in response to new challenges, essential for early immune response.
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IgA (Immunoglobulin A) – Plays a key role in mucosal immunity in the lungs, sinuses, and GI tract, found in saliva and tears.
Mega IgG2000™ works entirely within the gut lumen, providing immune support without entering the bloodstream. It complements probiotic and gut-repair protocols, especially in individuals with compromised gut barrier or immune imbalances.
Supplement Facts
Serving Size: 4 capsules
Servings Per Container: 30
| Ingredient | Amount per Serving | % Daily Value |
|---|---|---|
| Serum-derived immunoglobulin concentrate (ImmunoLin®) | 2 g | — |
| of which IgG | 900 mg | — |
| Protein | 2 g | 4% |
Other Ingredients:
Microcrystalline cellulose, vegetable capsule (cellulose and water)
No dairy, no gluten, no GMOs
Suggested Use
Adults and children age 8+:
Take 4 capsules daily between meals or at bedtime, or as directed by your healthcare practitioner.
Drink plenty of fluids.
Children under 8: Use only under supervision of a healthcare provider.
Mega IgG2000™ can be used on its own or in combination with gut-repair protocols such as Total Gut Restoration.
Frequently Asked Questions (FAQ)
Q: Is Mega IgG2000™ the same as colostrum?
A: No. It is derived from bovine serum, not dairy colostrum, and contains no lactose or casein.
Q: Can I use this with probiotics?
A: Yes. It pairs well with probiotics and other GI support supplements like MegaSporeBiotic™.
Q: Does it enter the bloodstream?
A: No. Mega IgG2000™ works exclusively in the gut lumen to bind toxins and microbes locally.
Q: Who may benefit from this product?
A: Individuals with leaky gut, GI inflammation, poor detoxification, or compromised immune function may find this helpful.
Digestive comfort, histamine metabolism support
Cheers to digestive comfort! If you experience occasional gas and stomach upset, as well as other gastrointestinal discomforts when enjoying wine, cured meats, cheese, fermented foods or citrus, you may have a sensitivity to dietary histamine. (Note: this is not the same as a food allergy.) Our formula helps you make friends with your food again by supporting the healthy breakdown of intestinal histamine to encourage gastrointestinal comfort.
What is Food Sensitivity Relief* with Diamine Oxidase (DAO)?
Digestive comfort may not always be on the menu when we pair a glass of wine (or beer) with snacks like cured meats, cheeses, citrus and fermented foods. Food Sensitivity Relief with Diamine Oxidase is formulated to help relieve occasional non-allergy digestive discomfort associated with dietary histamine sensitivity.
Make friends with your favorite foods again by encouraging healthy metabolism of histamine-rich foods like cured meats, cheeses and wine.
Food Sensitivity Relief with Diamine Oxidase
- Helps alleviate occasional gas and stomach upset, as well as other gastrointestinal discomforts
- Supports histamine metabolism for digestive comfort
- Provides support for when you snack on histamine-rich foods and drinks like cured meats, cheeses, wine
How to Stay Comfortable After You Eat
Cured meats, cheeses, wine, and other histamine-rich foods make for a delicious charcuterie board, but not everyone can digest these treats comfortably. Our plant-based DAO formula helps relieve occasional non-allergy digestive discomfort associated with intestinal dietary histamine sensitivity. One more thing: many DAO formulas utilize enzymes derived from animals—usually pork. But our formula uses diamine oxidase from pea sprouts. It’s got the same capacity to break down histamine as animal-based DAO…no pork bellies required.
What is a food sensitivity?
Short answer: a food sensitivity is when the body responds to compounds in the food you eat. A food sensitivity (sometimes referred to as a food intolerance) can cause occasional gastrointestinal discomfort, and is often difficult to identify. A food sensitivity is not an allergic reaction.
That said, non-allergy food sensitivities are more common than you think: currently, almost 20% of the Westernized world’s population experience some type of food intolerance.1 Histamine is a compound found in many foods and drinks that has been associated with food sensitivity.
Histamine is a compound found in many foods and drinks that has been associated with food sensitivity such as occasional gas, stomach upset, as well as other gastrointestinal discomforts.
Diamine oxidase in clinical studies
Diamine oxidase (DAO) is the main enzyme that supports the healthy breakdown of intestinal histamine and encourages gastrointestinal comfort.
In a randomized clinical trial, participants who took dietary DAO supplementation 20 minutes before a main meal for eight weeks reported relief from occasional gastrointestinal discomfort.
Research also points to the effectiveness of DAO supplements in inhibiting the incidence and intensity of discomfort due to occasional food sensitivity associated with intestinal dietary histamine sensitivity.
Plant-derived DAO
Many sources of supplementary DAO are derived from pig kidneys. But our formula provides pea sprouts derived DAO with equivalent capacity to break down histamine as used in clinical studies.
Make friends with your favorite foods again with Food Sensitivity Relief with Diamine Oxidase (DAO)!
FAQ
What is histamine?
Histamine is a compound that plays a role in the body’s immune response. It is released in the body and can be produced by gut bacteria. Histamine can also be found in or increased by many foods and drinks. Excessive levels of histamine in the gut can cause occasional gastrointestinal-related discomfort including gas and bloating. The body has several enzymes that help break down this compound.
What types of foods are considered histamine-rich?
Histamine-rich foods and drinks are very common. Some of these include cured and deli meats, different types of cheese, alcoholic beverages like wine and beer, oily fish and even certain fruits and vegetables like citrus, tomatoes and strawberries.
Is histamine sensitivity considered an allergy?
No, histamine sensitivities are considered a sensitivity to histamine ingested from foods. Food sensitivities are the body’s response to compounds in the food you eat, sometimes referred to as food intolerances. Sensitivities are not considered to be the same as an allergic reaction. They may manifest in the form of occasional gastrointestinal discomforts.
Does this product break down whole-body histamine?
No, this product is only intended to help support the breakdown of intestinal histamine associated with non-allergy histamine-food sensitivity.
What is diamine oxidase (DAO)?
Diamine oxidase (DAO) is an enzyme produced by the body that breaks down histamine and is the primary way the body metabolizes histamine in the GI tract. Its activity is measured in HDU, or histamine degrading units. It can be more difficult for people with low levels of DAO to maintain a healthy balance of histamine.
What is in Food Sensitivity Relief with Diamine Oxidase (DAO)?
Food Sensitivity Relief with Diamine Oxidase contains 20,000 HDU of the enzyme diamine oxidase (DAO), derived from pea sprouts. HDU stands for histamine degrading units and is a measure of enzyme activity.
Who is Food Sensitivity Relief with Diamine Oxidase intended for?
Food Sensitivity Relief with Diamine Oxidase is intended for those who need help breaking down and metabolizing histamine in the gut and alleviating occasional discomforts associated with dietary histamine sensitivity.
When can I expect an effect?
In a study of people who took DAO immediately after eating histamine-rich foods, benefits were seen immediately. More long-term effects were observed after taking DAO daily for 4-8 weeks. Everybody is unique, however, so the time it takes to notice benefits can vary from person to person. We suggest following the study duration to determine product efficacy.
When is the best time to take Food Sensitivity Relief with Diamine Oxidase? Should it be taken with food or on an empty stomach?
We suggest taking one capsule before your heaviest meals, up to three times daily.
Will this supplement interact with my medication?
There is no indication that the nutrient in this formula would negatively interact with prescription medications. However, we always suggest that you inform your physician of any supplements you are taking.
Are there any cautions associated with this product?
Food Sensitivity Relief with Diamine Oxidase contains the following caution: This product breaks down histamine but won’t prevent severe allergic or gluten-related (celiac) reactions. Do not knowingly ingest food you are allergic to.
Has this product been tested for heavy metals, contaminants and potency?
All our raw materials and finished products go through stringent testing to meet our high-quality standards. Testing is performed for heavy metals, microbes, disintegration, potency, and quantity of active ingredients in the finished product. Only when finished products meet Life Extension’s specifications are they released for production. A finished product Certificate of Analysis (COA) can be provided upon request for all our products.
Are there any major allergens in this product?
Food Sensitivity Relief with Diamine Oxidase does not contain any of the 9 major allergens required on the label under the Food Allergy Safety, Treatment, Education, and Research (FASTER) Act. This means it is free of milk, eggs, fish, crustacean shellfish, tree nuts, peanuts, wheat, sesame and soybeans.
Where is this product manufactured?
Food Sensitivity Relief with Diamine Oxidase is manufactured in the USA in a GMP-compliant facility.
Is this product vegetarian?
Yes, this product is vegetarian and does not contain any animal-derived ingredients.
Is this product gluten-free?
Yes, this product is gluten-free.
Is this product non-GMO?
Yes, this product and all its ingredients are Life Extension verified non-GMO.
Can children take this product?
No. This product was designed for adults over 18. Always consult with your child’s pediatrician before giving them any supplements.
Non-GMO
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This product breaks down histamine but won’t prevent severe allergic or gluten-related (celiac) reactions. Do not knowingly ingest food you are allergic to. |
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- KEEP OUT OF REACH OF CHILDREN
- DO NOT EXCEED RECOMMENDED DOSE
- Do not purchase if outer seal is broken or damaged.
- When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.
HistaQuel® is a comprehensive formula providing a multi-faceted, systemic approach to supporting healthy mast cell function and histamine response.*
Mechanisms of Action*
- Promotes healthy amount of histamine release by supporting healthy mast cell function*
- Supports healthy level of histamine absorption by blocking histamine receptors (via competitive inhibition)*
Supplement Facts / Dosing
Ingredients
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Mast Cell Secure™ | 375 mg
- Quercefit®, Perilla Frutescens (seed) Extract, Luteolin, Fisetin
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HistaCheck™ | 200 mg
- Black Cumin (seed) Extract, Stinging Nettle (leaf) Extract
Vegetarian
GMO-free
Suggested Use: As a dietary supplement, take 2 capsules twice per day with or without meals.
Cautions: If pregnant or nursing, consult your health care professional before use.
COMPREHENSIVE MAST CELL SUPPORT*
HistaQuel® is a comprehensive formula providing a multi-faceted, systemic approach to supporting healthy mast cell function and histamine response.*
What is a mast cell?
Mast cells are part of the immune system and are primarily responsible for generating and releasing histamine in the body. Under typical conditions, this is a natural function of a healthy body working to rid itself of an allergen. However, mast cells can become overactive, releasing a cascade of histamine throughout the body, which results in heightened or continuous allergy symptoms.
Many allergy support supplements, such as diamine oxidase (DAO), focus on reducing histamine within the gut by utilizing enzymes to degrade the histamine. Unfortunately, this means they are limited in their function and only effective for reducing ingested histamine (i.e., histamine introduced to the body through the food we eat) within the GI tract. However, mast cells release histamine systemically. Therefore, when mast cells are activated, they release histamine throughout the body. Enzymes such as DAO do nothing to address the healthy function of mast cells or support the body's healthy response to histamine and therefore serve limited benefit.
How does HistaQuel® support mast cell health?
HistaQuel® utilizes a comprehensive approach to support healthy mast cell function and histamine response systemically.* Six clinically researched flavonoids and herbs have been combined to promote healthy levels of histamine production and healthy levels of histamine absorption. This holistic approach resulted in a comprehensive formula featuring dual mechanisms of action.*
Dual Mechanisms of Action*
- Promotes healthy amount of histamine release by supporting healthy mast cell function*
- Supports healthy level of histamine absorption by blocking histamine receptors (via competitive inhibition)
Features Constituents/Actions Benefits* Mast Cell Secure™ Fisetin, Luteolin, Perilla frutescens, Quercefit® Quercetin Phytosome® • Targeted flavonoid blend supports a healthy mast cell release of histamine
• Moderates interactions between mast cells and activated T cells
• Supports a healthy Th2 release of allergy promoting cytokines IL-4 and IL-5
• Supports a healthy IgE mediated release of histamine
• Highly bioavailable form of Quercetin with 20 times increased absorption compared to standard Quercetin in published researchHistaCheck™ Stinging Nettle Leaf, Black Cumin (seed) extract • Promotes a healthy level of histamine to bind to its receptors by competitive inhibition
• Supports management of a healthy immune system response to allergens
Quercetin Supplement — Enhanced Absorption for Immune & Respiratory Wellness
Description
Advanced plant-based quercetin formula using phytosome technology with sunflower lecithin to facilitate up to 20× higher absorption compared to standard quercetin products. Featuring QuerceFit™, a patented phospholipid quercetin derived from Sophora japonica, this capsule delivers superior bioavailability and performance.
Benefits
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Histamine and allergen response support – Helps regulate histamine release and support a healthy inflammatory response, easing common allergy symptoms.
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Immune system enhancement – Acts as a powerful antioxidant, supporting balanced immune cell function and defense.
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Respiratory system protection – Assists in soothing airway inflammation and promoting lung health, with antioxidant protection against oxidative stress.
Supplement Facts
Serving Size: 1 capsule
Servings Per Container: 60
Each Capsule Contains:
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QuerceFit™ Quercetin (from Sophora japonica extract / sunflower lecithin) — 250 mg
Features
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100% vegan
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Gluten-free
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No additives, fillers, or preservatives
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Non-GMO, clean formula
Suggested Use
Take 1 capsule twice daily, with or without food, or as directed by your healthcare provider.
What to Expect
Calming of seasonal allergy symptoms like sneezing, a runny nose, and watery eyes, along with improved immune response and respiratory comfort. For ongoing support, daily use is recommended.
Caution
High doses (over 1,000 mg daily) for prolonged periods may affect kidney health—periodic breaks are advised. Consult your healthcare provider before use if pregnant, nursing, taking medications, or managing a medical condition. Discontinue use and seek medical advice if adverse effects occur. Keep out of reach of children. Not intended to diagnose, treat, cure, or prevent any disease.
Specialized digestive enzyme blend specific for gluten, casein, and other small proteins
Benefits and Features
A proprietary blend of microbial enzymes, SerenAid® is specifically formulated to assist in breaking down a broad range of plant and animal proteins, including casein (milk and dairy products), gluten (wheat, rye, oats, barley, and other grains), and soy proteins. The inclusion of Exorphinase® differentiates SerenAid® from other digestive enzyme formulas. This proprietary, high-activity enzyme blend of peptidase and protease with dipeptidyl peptidase IV (DPP-IV) activity can assist in hydrolyzing small protein peptides, including casomorphins and gluteomorphins that can adversely affect the central nervous system in some individuals.† The enzymes in this formulation are pH-stable, demonstrating activity over a wide range of pH conditions (pH of 2 to 12).
SerenAid® Attributes
- First fungal-based enzyme formulation to offer dipeptidyl peptidase IV (DPP-IV) activity formulated to support the unique proteolytic needs of children on the spectrum†
- High serine proteinase DPP-IV activity, to cleave the post-proline bonds and prolyl bonds near the N-terminus of proteins and peptides†
- Post-proline and prolyl bond cleavage supports proteolysis of casein, gluten, and their exorphin peptides, casomorphins, and gluteomorphins†
- Proprietary, patented‡‡ combination of peptidase and protease enzymes with DPP-IV activity to support hydrolysis of exorphin (opiate-acting) peptides†
- ‡‡US Patents 6,808,708, 6,821,514, 6,251,391, 6,447,772.
Detail Overview
Highly active microbial enzymes including DPP-IV to help digest a wide range of plant and animal proteins, including casein, gluten, soy, and others that may affect the central nervous system in some people when not completely broken down.†
SUPPLEMENT FACTS
| Serving Size 2 Capsules | ||
| Amount Per 2 Capsules | % Daily Value | |
|---|---|---|
| Exorphinase® Proprietary Enzyme Blend Providing
Peptidase and Protease Enzymes (54,000 HUT, 130 LAPU, 50 SAP)? with Endopeptidase, Exopeptidase, and Dipeptidyl Peptidase IV (DPP-IV) activity and 20 mg Lactase (2,000 ALC)? |
450 mg | * |
| * Daily value not established | ||
Other Ingredients:
Vegetarian capsule (hydroxypropyl methylcellulose, water), microcrystalline cellulose, and ascorbyl palmitate.
ΔUnits are those used in the Food Chemicals Codex (FCC).
Suggested Use
2 capsules at the beginning of each meal or as directed by a healthcare professional.
Allergy Statement
Free of the following common allergens: milk/casein, eggs, fish, shellfish, tree nuts, and peanuts. Contains no artificial colors, flavors, or preservatives.
Caution
If you are pregnant, nursing, have a medical condition, or taking prescription drugs, consult your physician before using this product. KEEP OUT OF REACH OF CHILDREN.