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Digestive comfort, histamine metabolism support
Cheers to digestive comfort! If you experience occasional gas and stomach upset, as well as other gastrointestinal discomforts when enjoying wine, cured meats, cheese, fermented foods or citrus, you may have a sensitivity to dietary histamine. (Note: this is not the same as a food allergy.) Our formula helps you make friends with your food again by supporting the healthy breakdown of intestinal histamine to encourage gastrointestinal comfort.
What is Food Sensitivity Relief* with Diamine Oxidase (DAO)?
Digestive comfort may not always be on the menu when we pair a glass of wine (or beer) with snacks like cured meats, cheeses, citrus and fermented foods. Food Sensitivity Relief with Diamine Oxidase is formulated to help relieve occasional non-allergy digestive discomfort associated with dietary histamine sensitivity.
Make friends with your favorite foods again by encouraging healthy metabolism of histamine-rich foods like cured meats, cheeses and wine.
Food Sensitivity Relief with Diamine Oxidase
- Helps alleviate occasional gas and stomach upset, as well as other gastrointestinal discomforts
- Supports histamine metabolism for digestive comfort
- Provides support for when you snack on histamine-rich foods and drinks like cured meats, cheeses, wine
How to Stay Comfortable After You Eat
Cured meats, cheeses, wine, and other histamine-rich foods make for a delicious charcuterie board, but not everyone can digest these treats comfortably. Our plant-based DAO formula helps relieve occasional non-allergy digestive discomfort associated with intestinal dietary histamine sensitivity. One more thing: many DAO formulas utilize enzymes derived from animals—usually pork. But our formula uses diamine oxidase from pea sprouts. It’s got the same capacity to break down histamine as animal-based DAO…no pork bellies required.
What is a food sensitivity?
Short answer: a food sensitivity is when the body responds to compounds in the food you eat. A food sensitivity (sometimes referred to as a food intolerance) can cause occasional gastrointestinal discomfort, and is often difficult to identify. A food sensitivity is not an allergic reaction.
That said, non-allergy food sensitivities are more common than you think: currently, almost 20% of the Westernized world’s population experience some type of food intolerance.1 Histamine is a compound found in many foods and drinks that has been associated with food sensitivity.
Histamine is a compound found in many foods and drinks that has been associated with food sensitivity such as occasional gas, stomach upset, as well as other gastrointestinal discomforts.
Diamine oxidase in clinical studies
Diamine oxidase (DAO) is the main enzyme that supports the healthy breakdown of intestinal histamine and encourages gastrointestinal comfort.
In a randomized clinical trial, participants who took dietary DAO supplementation 20 minutes before a main meal for eight weeks reported relief from occasional gastrointestinal discomfort.
Research also points to the effectiveness of DAO supplements in inhibiting the incidence and intensity of discomfort due to occasional food sensitivity associated with intestinal dietary histamine sensitivity.
Plant-derived DAO
Many sources of supplementary DAO are derived from pig kidneys. But our formula provides pea sprouts derived DAO with equivalent capacity to break down histamine as used in clinical studies.
Make friends with your favorite foods again with Food Sensitivity Relief with Diamine Oxidase (DAO)!
FAQ
What is histamine?
Histamine is a compound that plays a role in the body’s immune response. It is released in the body and can be produced by gut bacteria. Histamine can also be found in or increased by many foods and drinks. Excessive levels of histamine in the gut can cause occasional gastrointestinal-related discomfort including gas and bloating. The body has several enzymes that help break down this compound.
What types of foods are considered histamine-rich?
Histamine-rich foods and drinks are very common. Some of these include cured and deli meats, different types of cheese, alcoholic beverages like wine and beer, oily fish and even certain fruits and vegetables like citrus, tomatoes and strawberries.
Is histamine sensitivity considered an allergy?
No, histamine sensitivities are considered a sensitivity to histamine ingested from foods. Food sensitivities are the body’s response to compounds in the food you eat, sometimes referred to as food intolerances. Sensitivities are not considered to be the same as an allergic reaction. They may manifest in the form of occasional gastrointestinal discomforts.
Does this product break down whole-body histamine?
No, this product is only intended to help support the breakdown of intestinal histamine associated with non-allergy histamine-food sensitivity.
What is diamine oxidase (DAO)?
Diamine oxidase (DAO) is an enzyme produced by the body that breaks down histamine and is the primary way the body metabolizes histamine in the GI tract. Its activity is measured in HDU, or histamine degrading units. It can be more difficult for people with low levels of DAO to maintain a healthy balance of histamine.
What is in Food Sensitivity Relief with Diamine Oxidase (DAO)?
Food Sensitivity Relief with Diamine Oxidase contains 20,000 HDU of the enzyme diamine oxidase (DAO), derived from pea sprouts. HDU stands for histamine degrading units and is a measure of enzyme activity.
Who is Food Sensitivity Relief with Diamine Oxidase intended for?
Food Sensitivity Relief with Diamine Oxidase is intended for those who need help breaking down and metabolizing histamine in the gut and alleviating occasional discomforts associated with dietary histamine sensitivity.
When can I expect an effect?
In a study of people who took DAO immediately after eating histamine-rich foods, benefits were seen immediately. More long-term effects were observed after taking DAO daily for 4-8 weeks. Everybody is unique, however, so the time it takes to notice benefits can vary from person to person. We suggest following the study duration to determine product efficacy.
When is the best time to take Food Sensitivity Relief with Diamine Oxidase? Should it be taken with food or on an empty stomach?
We suggest taking one capsule before your heaviest meals, up to three times daily.
Will this supplement interact with my medication?
There is no indication that the nutrient in this formula would negatively interact with prescription medications. However, we always suggest that you inform your physician of any supplements you are taking.
Are there any cautions associated with this product?
Food Sensitivity Relief with Diamine Oxidase contains the following caution: This product breaks down histamine but won’t prevent severe allergic or gluten-related (celiac) reactions. Do not knowingly ingest food you are allergic to.
Has this product been tested for heavy metals, contaminants and potency?
All our raw materials and finished products go through stringent testing to meet our high-quality standards. Testing is performed for heavy metals, microbes, disintegration, potency, and quantity of active ingredients in the finished product. Only when finished products meet Life Extension’s specifications are they released for production. A finished product Certificate of Analysis (COA) can be provided upon request for all our products.
Are there any major allergens in this product?
Food Sensitivity Relief with Diamine Oxidase does not contain any of the 9 major allergens required on the label under the Food Allergy Safety, Treatment, Education, and Research (FASTER) Act. This means it is free of milk, eggs, fish, crustacean shellfish, tree nuts, peanuts, wheat, sesame and soybeans.
Where is this product manufactured?
Food Sensitivity Relief with Diamine Oxidase is manufactured in the USA in a GMP-compliant facility.
Is this product vegetarian?
Yes, this product is vegetarian and does not contain any animal-derived ingredients.
Is this product gluten-free?
Yes, this product is gluten-free.
Is this product non-GMO?
Yes, this product and all its ingredients are Life Extension verified non-GMO.
Can children take this product?
No. This product was designed for adults over 18. Always consult with your child’s pediatrician before giving them any supplements.
Non-GMO
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This product breaks down histamine but won’t prevent severe allergic or gluten-related (celiac) reactions. Do not knowingly ingest food you are allergic to. |
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- KEEP OUT OF REACH OF CHILDREN
- DO NOT EXCEED RECOMMENDED DOSE
- Do not purchase if outer seal is broken or damaged.
- When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.
HistaQuel® from Researched Nutritionals is a vegetarian capsule formula designed to support healthy mast cell function and histamine response.* The formula combines Mast Cell Secure™ and HistaCheck™ with Quercefit®, Perilla Frutescens seed extract, luteolin, fisetin, black cumin seed extract, and stinging nettle leaf extract.
This product is sold as 120 capsules and provides a multifaceted approach to supporting healthy histamine release and absorption.*
Key Benefits
- Supports healthy mast cell function and histamine release.*
- Supports a healthy histamine response through competitive inhibition at histamine receptors.*
- Combines flavonoids and botanical extracts in a comprehensive formula.*
- Vegetarian and GMO-free.
Ingredient Breakdown
| Ingredient or Feature | Role in the Formula |
|---|---|
| Mast Cell Secure™ | Combines Quercefit®, perilla seed extract, luteolin, and fisetin to support healthy mast cell function and histamine release.* |
| HistaCheck™ | Combines black cumin seed extract and stinging nettle leaf extract to support a healthy level of histamine absorption through competitive inhibition.* |
| Quercefit® | Provides a quercetin phytosome® form within the Mast Cell Secure™ blend.* |
| Vegetarian | Suitable for a vegetarian formula preference. |
| GMO-free | Made without genetically modified ingredients. |
How It Works
HistaQuel® uses two complementary formula approaches. Mast Cell Secure™ supports healthy mast cell function and the release of histamine, while HistaCheck™ supports a healthy level of histamine binding to its receptors through competitive inhibition.* Together, these blends provide comprehensive support for a healthy histamine response.*
Suggested Use
As a dietary supplement, take 2 capsules twice per day with or without meals.
Caution
If pregnant or nursing, consult your health care professional before use.
Quality & Certifications
- Vegetarian
- GMO-free
Frequently Asked Questions
What is HistaQuel® designed to support?
HistaQuel® is designed to support healthy mast cell function and histamine response.*
What formula blends are included?
The formula includes Mast Cell Secure™ and HistaCheck™.
What ingredients are in Mast Cell Secure™?
Mast Cell Secure™ includes Quercefit®, perilla seed extract, luteolin, and fisetin.
What ingredients are in HistaCheck™?
HistaCheck™ includes black cumin seed extract and stinging nettle leaf extract.
How should HistaQuel® be taken?
Take 2 capsules twice per day with or without meals.
Is HistaQuel® vegetarian and GMO-free?
Yes. HistaQuel® is vegetarian and GMO-free.
Quercetin 60 capsules Global Healing provide a plant-based quercetin formula featuring QuerceFit™ quercetin from Sophora japonica extract with sunflower lecithin. The formula uses phytosome technology and is designed to support immune, histamine-response, and respiratory wellness.
Each package contains 60 capsules. The clean formula is made with no additives, fillers, or preservatives and uses a phospholipid format designed to support quercetin absorption.
Key Benefits
- Histamine-response support: Helps support a balanced histamine response and healthy inflammatory response.
- Immune support: Provides antioxidant support for balanced immune cell function and natural defense.
- Respiratory wellness: Supports respiratory comfort and antioxidant protection against oxidative stress.
- Enhanced-absorption formula: Features QuerceFit™ and phytosome technology with sunflower lecithin.
Ingredient Breakdown
| Ingredient or Feature | Role in the Formula |
|---|---|
| QuerceFit™ quercetin | Provides the formula’s plant-based quercetin component for antioxidant, immune, histamine-response, and respiratory support. |
| Sophora japonica extract | Source of the QuerceFit™ quercetin ingredient. |
| Sunflower lecithin | Part of the phospholipid phytosome format designed to support absorption. |
| Phytosome technology | Formula technology used to support quercetin absorption. |
How It Works
QuerceFit™ quercetin from Sophora japonica extract is combined with sunflower lecithin in a phytosome format. Together, these formula features are designed to support quercetin absorption while providing antioxidant support for immune, histamine-response, and respiratory wellness.
Suggested Use
Take 1 capsule twice daily, with or without food, or as directed by your healthcare provider.
Caution
High doses (over 1,000 mg daily) for prolonged periods may affect kidney health—periodic breaks are advised. Consult your healthcare provider before use if pregnant, nursing, taking medications, or managing a medical condition. Discontinue use and seek medical advice if adverse effects occur. Keep out of reach of children. Not intended to diagnose, treat, cure, or prevent any disease.
Quality & Certifications
- 100% vegan
- Gluten-free
- No additives, fillers, or preservatives
- Non-GMO
- Clean formula
Frequently Asked Questions
What is Quercetin 60 capsules Global Healing designed to support?
It is designed to support immune, histamine-response, respiratory, and antioxidant wellness.
What is the key ingredient?
The formula features QuerceFit™ quercetin from Sophora japonica extract with sunflower lecithin.
What technology does this formula use?
It uses phytosome technology with sunflower lecithin to support quercetin absorption.
How should this supplement be taken?
Take 1 capsule twice daily, with or without food, or as directed by your healthcare provider.
What dietary features does the formula have?
It is 100% vegan, gluten-free, non-GMO, and made without additives, fillers, or preservatives.
Specialized digestive enzyme blend specific for gluten, casein, and other small proteins
Benefits and Features
A proprietary blend of microbial enzymes, SerenAid® is specifically formulated to assist in breaking down a broad range of plant and animal proteins, including casein (milk and dairy products), gluten (wheat, rye, oats, barley, and other grains), and soy proteins. The inclusion of Exorphinase® differentiates SerenAid® from other digestive enzyme formulas. This proprietary, high-activity enzyme blend of peptidase and protease with dipeptidyl peptidase IV (DPP-IV) activity can assist in hydrolyzing small protein peptides, including casomorphins and gluteomorphins that can adversely affect the central nervous system in some individuals.† The enzymes in this formulation are pH-stable, demonstrating activity over a wide range of pH conditions (pH of 2 to 12).
SerenAid® Attributes
- First fungal-based enzyme formulation to offer dipeptidyl peptidase IV (DPP-IV) activity formulated to support the unique proteolytic needs of children on the spectrum†
- High serine proteinase DPP-IV activity, to cleave the post-proline bonds and prolyl bonds near the N-terminus of proteins and peptides†
- Post-proline and prolyl bond cleavage supports proteolysis of casein, gluten, and their exorphin peptides, casomorphins, and gluteomorphins†
- Proprietary, patented‡‡ combination of peptidase and protease enzymes with DPP-IV activity to support hydrolysis of exorphin (opiate-acting) peptides†
- ‡‡US Patents 6,808,708, 6,821,514, 6,251,391, 6,447,772.
Detail Overview
Highly active microbial enzymes including DPP-IV to help digest a wide range of plant and animal proteins, including casein, gluten, soy, and others that may affect the central nervous system in some people when not completely broken down.†
SUPPLEMENT FACTS
| Serving Size 2 Capsules | ||
| Amount Per 2 Capsules | % Daily Value | |
|---|---|---|
| Exorphinase® Proprietary Enzyme Blend Providing
Peptidase and Protease Enzymes (54,000 HUT, 130 LAPU, 50 SAP)? with Endopeptidase, Exopeptidase, and Dipeptidyl Peptidase IV (DPP-IV) activity and 20 mg Lactase (2,000 ALC)? |
450 mg | * |
| * Daily value not established | ||
Other Ingredients:
Vegetarian capsule (hydroxypropyl methylcellulose, water), microcrystalline cellulose, and ascorbyl palmitate.
ΔUnits are those used in the Food Chemicals Codex (FCC).
Suggested Use
2 capsules at the beginning of each meal or as directed by a healthcare professional.
Allergy Statement
Free of the following common allergens: milk/casein, eggs, fish, shellfish, tree nuts, and peanuts. Contains no artificial colors, flavors, or preservatives.
Caution
If you are pregnant, nursing, have a medical condition, or taking prescription drugs, consult your physician before using this product. KEEP OUT OF REACH OF CHILDREN.
