Kava Calm Px 30 capsules Restorative Formulations

The following is a summary from the World Health Organization about kava hepatotoxicity.

The mechanism of kava hepatotoxicity (if any) is not yet understood (Anke & Ramzan 2004; Ernst 2004; Mathews 2005). The significance of the information concerning kava's possible hepatoxicity prior to 1998 is unclear. The forms of kava used traditionally by Pacific Islanders and by some Aboriginal communities are not believed to be associated with the serious forms of liver damage observed in the case reports (TGA Fact Sheet 2005).

In addition, despite all the new information, hypotheses and theories, the mechanism of toxicity remains unknown and there are no clear predictors of toxicity, such as dosage or type of organic (acetone or ethanol) preparation, drug interactions etc, making the onset of damage unpredictable. No specific risk factors have been identified which may allow the safe use of kava under restricted conditions such as limiting the duration of treatment or its use in specific patient groups. Most experts believe that the available data point to an idiosyncratic-immunological genesis for the liver toxicity (Russmann eta!, 2001; Schmidt 2003; Teschke 2003).

According to recent analyses, kava can potentially produce liver toxicity but the incidence of those effects appears to be extremely low (Schmidt 2003; Edwards 2005; Miller 1998).

Experimental hepatic toxicological investigations showed no overt hepatotoxic reactions due to kava pyrones. A number of comprehensive reviews have been published in an attempt to explain the cause-effect relationship observed in the case reports but to date a clear mechanism to explain this purported hepatotoxicity has not been found.

Serving Size: 2

Servings Per Container: 15

Suggested Use: 1 to 2 vegi-caps twice daily as needed, with or without food, or as recommended by your healthcare practitioner. Can be taken with or without food.

Ingredients	Amount Per Serving	% Daily Value
Kava Root Extract (Piper methysticum)     Kavalactones 240 mg	800 mg	†
† Daily Value (DV) not established Organic Herbs are Certified Organic

Other Ingredients: Hypromellose vegetable capsule

This product is free of GMO, Gluten, wheat, saturated fats, sugar, dairy, yeast, and corn.

Cautions: Ask health care professional before using if you have or have had liver problems, frequently use alcoholic beverages or are taking medications. Stop use and see your doctor in the unlikely case that you develop symptoms that may signal liver problems (e.g., unexplained fatigue, abdominal pain, loss of appetite, fever, vomiting, dark urine, pale stools, yellow eyes or skin).
Kava may potentiate alcohol, barbiturates, and substances affecting mental activity and the central nervous system and drugs that promote relaxation. This indicates that Kava may be used concurrently to help diminish doses and eventually help one to get off more toxic medication. This must be done only under the supervision of a qualified healthcare professional.