An exercise and caloric restriction mimetic that improves
Sirtuin and NAD+ functions. This low-dose leucine
compound is best known for its incredible enhancement
of weight loss with GLP 1’s like semaglutide.

LeuSynergy + GLP-1s has become a
foundational protocol for weight loss
and metabolism optimization.

Cellular Pathways
Delivering the right dose of Leucine decreases the amount
of NAD needed to activate SIRT-1.

* Leucine at a concentration of 0.5mM was shown to decrease the kM of NAD by 50% 
With Leucine, LESS NAD+ is needed for SIRT-1 functions, improving NAD+ utilization in other cellular pathways.

Why this matters: SIRT-1 Downstream Effects
Stimulates caloric restriction and exercise pathways through these gene transcription factors::
PGC-1a: The core regulator of mitochondrial biogenesis, PPAR: Regulate fat oxidation, AMPK: Master regulator of cell energy, NF-kB: Inhibition leads to decreased inflammation and oxidative stress 

Clinical Studies

Leucine-Resveratrol Synergy

Human Pre-diabetic Subjects Randomized:

Leucine 1.1 g + Resveratrol 50mg Twice Daily vs. Placebo

•     OGTT and 60 min glucose and insulin concentration
•    Reduced insulin resistance by 33%
•    Significant improvement and insulin/glucose dynamics

Weight Loss – Fat Oxidation – Insulin Sensitivity

Synergy with GLP-1s: Semaglutide, Tirzepatide, Liraglutide

Studies show 15% reduction in body weight when semaglutide was accompanied by caloric restriction and exercise. Using an exercise mimetic like LeuSynergy is foundational in weight loss and metabolic health outcomes. 

Insulin Independent Pathways for Glucose Disposal
GLP-1: Increase in GLUT4 expression by activating AMPK
LeuSynergy: Increase in GLUT4 expression through SIRT1  deacetylation of PGC-1a

Improved Fat Oxidation
GLP-1: Direct effects on  hepatocytes by activating genes involved in beta-oxidation of fatty acids
LeuSynergy: Activation of PGC-1a and PPAR resulting in an increase in fatty acid oxidation and oxidative phosphorylation

Oxidative Stress and Pancreatic  Beta Cell Protection
GLP-1: Reduced oxidative stress in pancreatic islets. Increases 
B-cell mass by regulating cell kinectics and suppressing  oxidative and ER stress, and amerlioration of glucolipotoxicity.
LeuSynergy: SIRT1 deacetylation and inhibition of NF-kB protecting beta cells from oxidative stress and inflammatory cytokines. 

Ingredients