About Life Extension
Life Extension is a privately owned vitamin and supplement company founded in 1980 and headquartered in Fort Lauderdale, Florida.
The brand offers a broad range of science-based supplements, vitamins, minerals, antioxidants, probiotics, specialty formulas, and wellness products across many health categories.
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Digestive comfort, histamine metabolism support
Cheers to digestive comfort! If you experience occasional gas and stomach upset, as well as other gastrointestinal discomforts when enjoying wine, cured meats, cheese, fermented foods or citrus, you may have a sensitivity to dietary histamine. (Note: this is not the same as a food allergy.) Our formula helps you make friends with your food again by supporting the healthy breakdown of intestinal histamine to encourage gastrointestinal comfort.
What is Food Sensitivity Relief* with Diamine Oxidase (DAO)?
Digestive comfort may not always be on the menu when we pair a glass of wine (or beer) with snacks like cured meats, cheeses, citrus and fermented foods. Food Sensitivity Relief with Diamine Oxidase is formulated to help relieve occasional non-allergy digestive discomfort associated with dietary histamine sensitivity.
Make friends with your favorite foods again by encouraging healthy metabolism of histamine-rich foods like cured meats, cheeses and wine.
Food Sensitivity Relief with Diamine Oxidase
- Helps alleviate occasional gas and stomach upset, as well as other gastrointestinal discomforts
- Supports histamine metabolism for digestive comfort
- Provides support for when you snack on histamine-rich foods and drinks like cured meats, cheeses, wine
How to Stay Comfortable After You Eat
Cured meats, cheeses, wine, and other histamine-rich foods make for a delicious charcuterie board, but not everyone can digest these treats comfortably. Our plant-based DAO formula helps relieve occasional non-allergy digestive discomfort associated with intestinal dietary histamine sensitivity. One more thing: many DAO formulas utilize enzymes derived from animals—usually pork. But our formula uses diamine oxidase from pea sprouts. It’s got the same capacity to break down histamine as animal-based DAO…no pork bellies required.
What is a food sensitivity?
Short answer: a food sensitivity is when the body responds to compounds in the food you eat. A food sensitivity (sometimes referred to as a food intolerance) can cause occasional gastrointestinal discomfort, and is often difficult to identify. A food sensitivity is not an allergic reaction.
That said, non-allergy food sensitivities are more common than you think: currently, almost 20% of the Westernized world’s population experience some type of food intolerance.1 Histamine is a compound found in many foods and drinks that has been associated with food sensitivity.
Histamine is a compound found in many foods and drinks that has been associated with food sensitivity such as occasional gas, stomach upset, as well as other gastrointestinal discomforts.
Diamine oxidase in clinical studies
Diamine oxidase (DAO) is the main enzyme that supports the healthy breakdown of intestinal histamine and encourages gastrointestinal comfort.
In a randomized clinical trial, participants who took dietary DAO supplementation 20 minutes before a main meal for eight weeks reported relief from occasional gastrointestinal discomfort.
Research also points to the effectiveness of DAO supplements in inhibiting the incidence and intensity of discomfort due to occasional food sensitivity associated with intestinal dietary histamine sensitivity.
Plant-derived DAO
Many sources of supplementary DAO are derived from pig kidneys. But our formula provides pea sprouts derived DAO with equivalent capacity to break down histamine as used in clinical studies.
Make friends with your favorite foods again with Food Sensitivity Relief with Diamine Oxidase (DAO)!
FAQ
What is histamine?
Histamine is a compound that plays a role in the body’s immune response. It is released in the body and can be produced by gut bacteria. Histamine can also be found in or increased by many foods and drinks. Excessive levels of histamine in the gut can cause occasional gastrointestinal-related discomfort including gas and bloating. The body has several enzymes that help break down this compound.
What types of foods are considered histamine-rich?
Histamine-rich foods and drinks are very common. Some of these include cured and deli meats, different types of cheese, alcoholic beverages like wine and beer, oily fish and even certain fruits and vegetables like citrus, tomatoes and strawberries.
Is histamine sensitivity considered an allergy?
No, histamine sensitivities are considered a sensitivity to histamine ingested from foods. Food sensitivities are the body’s response to compounds in the food you eat, sometimes referred to as food intolerances. Sensitivities are not considered to be the same as an allergic reaction. They may manifest in the form of occasional gastrointestinal discomforts.
Does this product break down whole-body histamine?
No, this product is only intended to help support the breakdown of intestinal histamine associated with non-allergy histamine-food sensitivity.
What is diamine oxidase (DAO)?
Diamine oxidase (DAO) is an enzyme produced by the body that breaks down histamine and is the primary way the body metabolizes histamine in the GI tract. Its activity is measured in HDU, or histamine degrading units. It can be more difficult for people with low levels of DAO to maintain a healthy balance of histamine.
What is in Food Sensitivity Relief with Diamine Oxidase (DAO)?
Food Sensitivity Relief with Diamine Oxidase contains 20,000 HDU of the enzyme diamine oxidase (DAO), derived from pea sprouts. HDU stands for histamine degrading units and is a measure of enzyme activity.
Who is Food Sensitivity Relief with Diamine Oxidase intended for?
Food Sensitivity Relief with Diamine Oxidase is intended for those who need help breaking down and metabolizing histamine in the gut and alleviating occasional discomforts associated with dietary histamine sensitivity.
When can I expect an effect?
In a study of people who took DAO immediately after eating histamine-rich foods, benefits were seen immediately. More long-term effects were observed after taking DAO daily for 4-8 weeks. Everybody is unique, however, so the time it takes to notice benefits can vary from person to person. We suggest following the study duration to determine product efficacy.
When is the best time to take Food Sensitivity Relief with Diamine Oxidase? Should it be taken with food or on an empty stomach?
We suggest taking one capsule before your heaviest meals, up to three times daily.
Will this supplement interact with my medication?
There is no indication that the nutrient in this formula would negatively interact with prescription medications. However, we always suggest that you inform your physician of any supplements you are taking.
Are there any cautions associated with this product?
Food Sensitivity Relief with Diamine Oxidase contains the following caution: This product breaks down histamine but won’t prevent severe allergic or gluten-related (celiac) reactions. Do not knowingly ingest food you are allergic to.
Has this product been tested for heavy metals, contaminants and potency?
All our raw materials and finished products go through stringent testing to meet our high-quality standards. Testing is performed for heavy metals, microbes, disintegration, potency, and quantity of active ingredients in the finished product. Only when finished products meet Life Extension’s specifications are they released for production. A finished product Certificate of Analysis (COA) can be provided upon request for all our products.
Are there any major allergens in this product?
Food Sensitivity Relief with Diamine Oxidase does not contain any of the 9 major allergens required on the label under the Food Allergy Safety, Treatment, Education, and Research (FASTER) Act. This means it is free of milk, eggs, fish, crustacean shellfish, tree nuts, peanuts, wheat, sesame and soybeans.
Where is this product manufactured?
Food Sensitivity Relief with Diamine Oxidase is manufactured in the USA in a GMP-compliant facility.
Is this product vegetarian?
Yes, this product is vegetarian and does not contain any animal-derived ingredients.
Is this product gluten-free?
Yes, this product is gluten-free.
Is this product non-GMO?
Yes, this product and all its ingredients are Life Extension verified non-GMO.
Can children take this product?
No. This product was designed for adults over 18. Always consult with your child’s pediatrician before giving them any supplements.
Non-GMO
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This product breaks down histamine but won’t prevent severe allergic or gluten-related (celiac) reactions. Do not knowingly ingest food you are allergic to. |
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- KEEP OUT OF REACH OF CHILDREN
- DO NOT EXCEED RECOMMENDED DOSE
- Do not purchase if outer seal is broken or damaged.
- When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.
Promotes Healthy Homocysteine Levels
Our innovative formula helps support and maintain already-healthy homocysteine levels to support cardiovascular health.
What Is TMG?
Trimethylglycine (TMG) has been linked to heart health by supporting already-healthy homocysteine levels to promote healthy cardiovascular function. By having a positive impact on your homocysteine levels, TMG helps you stay healthy by supporting multiple systems throughout your body.
TMG (also called glycine betaine) has been associated with beneficial effects on liver function and cardiovascular health.
TMG Powder Benefits
- Promotes healthy homocysteine levels already within normal range
- Helps inhibit inflammatory factors to encourage cardiovascular health
- Supports already-healthy blood pressure levels
- Encourages whole-body health
- Helps maintain healthy mitochondrial function
Over 50 Years of Research
Trimethylglycine has been known as a heart-healthy amino acid compound since the 1950s. That’s more than 50 years of scientific research to rely upon.
Trimethylglycine (TMG) is also called glycine betaine, but the name trimethylglycine signifies that it has three methyl groups attached to each molecule of glycine. Wheat bran is the main dietary source of TMG, with smaller amounts available in other cereal grains. TMG can also be made in the body from choline, an essential nutrient found in eggs, soybeans and many other foods.
TMG was found to be beneficial to heart health in the 1950s. Like some of the B vitamins (B6, B12 and folate), TMG is a methyl donor, providing extra methyl groups to hasten the conversion of homocysteine back to methionine. When a TMG methyl group is donated to a molecule of homocysteine, it converts it to the non-toxic amino acid, methionine.
The role of TMG in healthy homocysteine metabolism is even more important when B vitamin levels are low Some evidence suggests TMG may be more efficient at regulating homocysteine levels than folate. 9 Research showing TMG's ability to promote healthy levels of homocysteine already within normal range, alone or in conjunction with other nutrients, confirms its status as an important nutrient for cardiovascular and overall health.
TMG has been associated with healthy blood pressure and mitochondrial function, and has been found to be linked to cardiovascular health. TMG has also been found to promote healthy liver function. Studies show TMG can support a healthy inflammatory response by inhibiting expression of NFkappaB, TNF-alpha, and other inflammatory proteins, which may partially explain its positive impacts.14 Because intestinal microbes can make various by-products from TMG, the health of the gut microbiome influences the effects of TMG in the body.
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- KEEP OUT OF REACH OF CHILDREN
- DO NOT EXCEED RECOMMENDED DOSE
- Do not purchase if outer seal is broken or damaged.
- When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.
Supports healthy levels of this essential nutrient for thyroid health and beyond
Iodine is an essential, health-promoting trace element. Its primary biological role lies in supporting the production of thyroid hormones. Sea-Iodine™ provides 1,000 mcg of this essential element.
What Is Sea Iodine?
Iodine is a health-promoting trace element essential for life and usually ingested by consuming table salt. But many people avoid salt for health reasons. Sea-Iodine™ provides 1,000 mcg of this essential element, without upping your salt intake. Promote thyroid health and beyond with Sea-Iodine™.
Sea-Iodine™ uses ingredients harvested from a blend of organic marine algae to support healthy iodine levels.
Sea-Iodine™ Benefits
- Essential for thyroid health support
- Supports healthy iodine levels, without salt
- Convenient way to get your daily iodine intake
Trace Element Essential For Life
Iodine supports the production of two important thyroid hormones, triiodothyronine (T3) and thyroxine (T4). A healthy thyroid gland not only acts as your body’s thermostat, but it’s also one of the major maintainers of metabolism, including supporting fat burning for energy. Sea-Iodine™ proprietary formula helps health-conscious individuals support optimal iodine levels, without the salt.
Important for thyroid health support
Iodine is a health-promoting trace element essential for life. Its primary biological role lies in the production of the thyroid hormones triiodothyronine (T3) and thyroxine (T4).1 T4 and T3 contain four and three atoms of iodine per molecule, respectively. The thyroid gland actively absorbs iodide from the blood to make and release these hormones into the blood.
Get your iodine, without the salt
For decades, Americans have been told to avoid table salt. But when iodized table salt is reduced, people can unknowingly lower their iodine intake to suboptimal levels.
The good news is that you can avoid iodized table salt without sacrificing the health benefits of iodine. Sea-Iodine™ is a low-cost proprietary formula that health-conscious individuals can take each day to support optimal iodine levels. Using ingredients harvested from a blend of organic marine algae, Sea-Iodine™ brings you the health of the sea while avoiding excessive salt intake. The algae found in Sea-Iodine™ provide you with over 667% of the Recommended Daily Value of iodine.
Abundant in sea vegetation
Iodine happens to be found abundantly in sea vegetables and plants. In areas where no marine foods are eaten, people often have lower iodine levels. For this reason, U.S. commercial salt makers have long added iodine to deliver this key ingredient to your diet. However, we now know the concerns associated with eating too much table salt, which resurrects the dilemma of where to get healthy sources of iodine.
Ironically, health-conscious people are often the most likely to have low iodine levels. One reason is that athletes and people engaged in heavy physical effort deplete their healthy stores of this trace mineral through perspiration. Vegetarians and vegans also have a substantially greater likelihood of low levels of iodine than those who eat animal products. One study demonstrated iodine deficiency in 25% of vegetarians and an incredible 80% of vegans.
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If you have a thyroid condition or are taking antithyroid medications, do not use without consulting your healthcare practitioner. |
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- KEEP OUT OF REACH OF CHILDREN
- DO NOT EXCEED RECOMMENDED DOSE
- Do not purchase if outer seal is broken or damaged.
- When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.
Get the support of healthy omega-6 fatty acids and promote a healthy inflammatory response with our concentrated Mega GLA formula, which is enhanced with sesame lignans to boost effectiveness.
What Is Mega GLA Sesame Lignans?
Gamma-linolenic acid (GLA) is the precursor to the biologically active DGLA (dihomo-gamma linolenic acid), which has numerous health benefits. We’ve added sesame lignans to our formula to boost borage oil’s beneficial effects and inhibit GLA’s conversion into inflammatory factors like arachidonic acid, further supporting whole body health.
Enhancing our GLA supplement with sesame lignans enables GLA to work much better in the body, for greater health benefits.
Mega GLA Sesame Lignans Benefits
- Promotes a healthy inflammatory response
- Supports the formation of prostaglandin E1, Which promotes vascular health and more
- Encourages healthy levels of biologically active dihomo-gamma-linolenic acid
Getting the Right Omega-6
Not all omega-6 fatty acids are of equal value. Arachidonic acid (AA), for instance, is the precursor of inflammatory factors like prostaglandin E2 (PGE2), thromboxane A2, and leukotriene B4. In contrast, gamma-linolenic acid (GLA) plays a beneficial role in healthy prostaglandin (PGE1) formation and inhibiting inflammatory factors, both of which promote vascular as well as whole-body health.
Omega-6 fatty acids like linoleic acid are well-supplied in the diet by meat and vegetable oils. But some omega-6s can contribute to the production of inflammatory compounds such as prostaglandin E2 (PGE2), thromboxane A2 and leukotriene B4 (LTB4).
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If you are taking anticoagulant or antiplatelet medications, or have a bleeding disorder, consult your healthcare provider before taking this product. |
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- KEEP OUT OF REACH OF CHILDREN
- DO NOT EXCEED RECOMMENDED DOSE
- Do not purchase if outer seal is broken or damaged.
- When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.
Homocysteine Resist contains a selection of B vitamins specially formulated to help your body maintain already-healthy levels of homocysteine and to support heart and brain health.
What Is Homocysteine Resist?
Homocysteine Resist is a specially formulated B vitamin supplement for heart and brain health. Homocysteine is a natural compound produced by your cells. But over time, it can begin to build up in the bloodstream, affecting cardiovascular health, cognitive function and more.
This formulation combines vitamins B2 (riboflavin), B6 and B12, plus folate as L-5-methyltetrahydrofolate (L-5-MTHF).
Homocysteine Resist Benefits
- Promotes heart-healthy homocysteine levels already within normal range
- Supports a healthy vascular system
- Encourages neurotransmitter synthesis for cognitive health
- Supports cellular energy production with vitamin B2
- Contains the most potent forms of vitamins B6, B12 and folate
A B-Vitamin Punch
Homocysteine Resist combines vitamins B2, B6, B12 and folate as L-5-MTHF. Folate and vitamin B12 help maintain homocysteine levels within the normal range, and folate also supports neurotransmitter synthesis for cognitive health. Vitamin B6 also facilitates neurotransmitter synthesis, as well as amino acid and lipid metabolism. Vitamin B2 supports the body’s energy production.
Homocysteine Resist provides a targeted selection of B vitamins specially formulated for your heart and brain. It helps your body maintain heart-healthy levels of homocysteine already within normal range. Homocysteine is a natural compound produced by your cells. But over time, it can begin to build up in the bloodstream, affecting cardiovascular health, cognitive function and more.
°DFE (Dietary Folate Equivalents). Non-GMO |
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- KEEP OUT OF REACH OF CHILDREN
- DO NOT EXCEED RECOMMENDED DOSE
- Do not purchase if outer seal is broken or damaged.
- When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.
Discomfort Relief provides the benefits of 600 mg of PEA (palmitoylethanolamide) in a convenient, berry-flavored chewable tablet.
What Is Discomfort Relief?
PEA (palmitoylethanolamide) is a compound naturally produced by your body. We’ve packed 600 mg of PEA into a convenient, chewable tablet so you can live comfortably.
An estimated 144 million U.S. adults report having experienced some kind of pain in the previous three months.
Discomfort Relief Benefits
- Inhibits minor pain and discomfort
- Delivers convenience in berry-flavored chewables
Occasional, Minor Discomfort? We’ve Got You Covered
Discomfort Relief packs 600 mg of PEA (palmitoylethanolamide) into a convenient, chewable tablet that has been clinically studied to relieve occasional minor pain.
Discomfort Relief is a chewable supplement that relieves occasional minor pain. PEA (palmitoylethanolamide) is a compound naturally produced by your body. Now, we’ve packed 600 mg of PEA into a convenient, chewable tablet.
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- KEEP OUT OF REACH OF CHILDREN
- DO NOT EXCEED RECOMMENDED DOSE
- Do not purchase if outer seal is broken or damaged.
- When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.
PEA inhibits inflammatory factors to support nerve cell health. Honokiol encourages healthy levels of calming neurotransmitters in the brain. Together, they help alleviate minor discomfort.
What Is ComfortMAX?
ComfortMAX™ delivers two potent ingredients: palmitoylethanolamide (PEA) and honokiol, a compound derived from Magnolia bark. By promoting nerve comfort in two separate yet complementary ways, the ingredients in ComfortMAX™ help to inhibit nerve discomfort.
The reasons for physical discomfort vary, but the way we experience that discomfort doesn't. That's why we’ve created ComfortMAX™.
ComfortMAX™ Benefits
- Dual-action formula helps alleviate minor nerve discomfort
- Helps you stay comfortable throughout the day
- Provides morning and nighttime doses for around-the-clock support
The How & Why Behind ComfortMAX™
By inhibiting inflammatory compounds to promote nerve health and encouraging healthy neurotransmitter levels in your brain, ComfortMAX™ helps to reduce discomfort. Formulated to be taken twice a day, one tablet in the morning and one tablet at night right before bed, it helps with relieving discomfort—day and night.
According to the National Institutes of Health, nearly 25 million Americans experience daily discomfort. This kind of discomfort can affect mood, mobility and quality of life. The reasons for physical discomfort vary, but the way we experience that discomfort doesn’t: Our peripheral nerves are responsible for delivering sensory information (an itch, temperature change, physical pressure, etc.) to the brain. And that’s where ComfortMAX™ comes in.
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Non-GMO Dosage and Use
The blue PM tablet may cause mild sedation in some people. Take at bedtime. |
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- KEEP OUT OF REACH OF CHILDREN
- DO NOT EXCEED RECOMMENDED DOSE
- Do not purchase if outer seal is broken or damaged.
- When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.
Adding L-Carnitine to your supplement regimen provides a host of potential health benefits associated with aging. It starts with supporting mitochondria, which power every cell in your body.
What Is L-Carnitine?
Mitochondria, the powerhouses found within human cells, produce the energy that vital tissues need to keep us vibrant and healthy. Healthy levels of carnitine support optimum functioning of mitochondria and your body’s energy production.
Maintaining optimal mitochondrial function is important for many aspects of healthy aging.
L-Carnitine Benefits
- Helps maintain cellular metabolic activity
- Supports healthy concentration of nitric oxide, which helps support already-healthy blood pressure
- Supports the brain's natural defenses against age-related memory & cognitive decline
- Helps maintain healthy body composition
Protecting Cellular Energy
L-carnitine is an amino acid produced in your body. It plays an important role in moving fatty acids into the mitochondria of your cells. This is important, since as we age, there is a steady decline in cellular energy. The primary reason is that our mitochondria aren’t functioning properly. Healthy levels of carnitine support optimum functioning of mitochondria.
Mitochondria, the powerhouses found within human cells, produce the energy that vital tissues need to keep us vibrant and healthy. Healthy levels of carnitine support optimum functioning of mitochondria.1 The problem is that as we age, levels of carnitine decline in all our tissues, reducing cellular energy production and metabolic activity.
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- KEEP OUT OF REACH OF CHILDREN
- DO NOT EXCEED RECOMMENDED DOSE
- Do not purchase if outer seal is broken or damaged.
- When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.
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