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Apigenin is a flavonoid with a broad spectrum of biological
activities, including effects on metabolism, inflammation,
neuroprotection, and anti-cancer properties. It acts as a potent
inhibitor of CD38, a key enzyme that reduces NAD levels,
thereby influencing several cell signaling pathways.
Apigenin has also been shown to influence
weight, inflammation, and insulin resistance by
altering the gut microbiota and restoring the
richness and diversity of the gut microbiota.
Cellular Pathways
Inhibition of CD38 is the core pathway for
mitigating age related decline. CD38 is the
main enzyme that degrades NAD+.
Why this matters:
CD38 is abundant in inflammatory cells and key in the decline of NAD+, crucial for cell functions. With aging, CD38 expression, mRNA, and NADase activity increase, accelerating cellular aging. Overexpression of CD38 in cancer cells triggers aging-like features. Also, low-grade inflammation during aging boosts CD38 expression in inflammatory cells, leading to their accumulation in tissues, indicating CD38’s significant role in the cycle of aging and inflammation.
CD38 Degrades NAD+ Precursors: Implications for NAD+ Replacement Therapy
• CD38 is required for the age related NAD decline and mitochondrial dysfunction via a pathway mediated at least in part by regulation of the SIRT3 activity
• NAD replacement-based therapies with NMN and NR for metabolic dysfunction could be significantly improved by combination with CD38 inhibitors.
Synergy with NAD precursors, Guttides, Leusynergy:
Apigenin™ + (NMN, NR, 5-amino, NAD injection)
Apigenin in conjunction with NAD precursors like NMN, NR, 5-amino1mq and NAD injections create a systematic approach to cellular efficiency.
Apigenin™ + (Guttides, Larazotide, nuButyrate™)
Due to Apigenin effects on the microbiome and akkermensia it is commonly added to gut health protocol using Guttides, Larazotide and butryrate.
Apigenin™ + (GLP-1, Sermorelin, Leusynergy™, Sytrinol® LNA)
Apigenin is also used in combination with peptides and supplements that improve metabolism such as GLP-1s and Sermorelin.
30 CAPSULES
SERVING SIZE: 1
DIRECTIONS: Take 1 capsule daily
Amount Per Serving
Apigenin - 150mg
Cellulose (Capsule)
Rice Flour
Magnesium Stearate
Daily Value (DV) not established
Supports Healthy Heart, Metabolic, Neurocognitive, and Musculoskeletal Function
Benefits and Features
- Provides magnesium citrate, a highly soluble form of magnesium that can cross the blood-brain barrier.
- Supports more than 300 biochemical reactions in the body.
Detail Overview
Magnesium is essential for:
- Energy metabolism—converting carbohydrates, proteins, and fats into energy.
- Maintaining vascular and bone health.
- Regulating calcium and potassium balance.
- Supporting muscle contraction and relaxation.
- Facilitating nerve signal transmission throughout the body.
The glycinate form of magnesium is particularly well absorbed and utilized.
Supplement Facts
Serving Size: 1 Capsule
| Amount Per Capsule | % Daily Value | |
|---|---|---|
| Magnesium (as magnesium citrate complex) | 150 mg | 36% |
Other Ingredients:
Vegetarian capsule (hydroxypropyl methylcellulose, water), ascorbyl palmitate.
Suggested Use
- Adults: Take 1 capsule, 1 to 3 times daily with food or as directed by a healthcare professional.
- Children: Use as directed by a healthcare professional.
Allergy Statement
- Free from milk/casein, eggs, fish, shellfish, tree nuts, peanuts, wheat, gluten, soy, and sesame.
- Non-GMO, vegan, and free from synthetic colors and flavors.
Caution
- Consult your physician if you are pregnant, nursing, have a medical condition, take prescription medications, or are under 12 years of age.
- KEEP OUT OF REACH OF CHILDREN.
Jarrow Formulas® 5-HTP 5-Hydroxytryptophan) is an extract of Griffonia simplicifolia seeds from coastal West Africa. Purity is assured by HPLC. 5-HTP is the direct metabolic precursor to serotonin and is important for the production of melatonin, a hormone secreted by the pineal gland that aids biorhythm regulation.
- Help Support A Balanced Mood
- 5-HTP Is A Precursor To Serotonin
- 50 mg 5-HTP Per Serving
- Vegan, Non-GMO, Gluten Free
Suggested use
Adults take 1 capsule once a day on an empty stomach or as directed by your qualified healthcare professional.
WARNING: Consult a healthcare professional before using this product if you are pregnant, nursing, under the age of 18, are taking medication (especially if taking SSRIs, MAOs, or sedative medications) or have a medical condition; if adverse reactions occur, discontinue use.
KEEP OUT OF THE REACH OF CHILDREN.
STORE IN A COOL, DRY PLACE.
| Supplement facts | ||
| Serving Size: 1 Capsule | ||
| Amount Per Serving | % DV | |
| 5-HTP (5-Hydroxytryptophan) (from Griffonia simplicifolia) (Seed) | 50 mg | † |
| † Daily Value (DV) not established. | ||
Other ingredients
Microcrystalline cellulose, capsule (hydroxypropylmethylcellulose, water), magnesium stearate (vegetable source) and silicon dioxide.
No wheat, gluten, soybeans, dairy, egg, fish/shellfish, peanuts/tree nuts or sesame.
Zenbiome™ Cope – Advanced Psychobiotic Support for Stress, Mood & Cognitive Health, 60 Capsules
Microbiome Labs
Targeted Gut-Brain Axis Support with Psychobiotic 1714™
Zenbiome™ Cope is a clinically formulated psychobiotic supplement designed to support the body’s response to occasional stress, mood changes, and mental fatigue. Powered by the extensively studied Bifidobacterium longum 1714™, and reinforced with essential B vitamins and saffron extract, Zenbiome™ Cope delivers targeted gut-brain axis support to help you stay calm, focused, and resilient throughout daily challenges.
Key Benefits
-
Helps manage occasional stress and mental fatigue
-
Supports calm mood and emotional balance
-
Enhances memory, cognitive function, and brainwave activity
-
Promotes energy levels and resilience under stress
-
Regulates HPA axis and cortisol response
-
Supports gut-brain communication through the psychobiome
Science Behind Zenbiome™ Cope
The Gut-Brain Axis & Psychobiotic 1714™
The gut-brain axis is the bidirectional communication network between the gastrointestinal system and the brain. An imbalanced gut microbiome may impact neurotransmitter signaling, mood regulation, and stress responses.
Zenbiome™ Cope features Bifidobacterium longum 1714™, a unique psychobiotic strain that modulates brainwave patterns, reduces perceived stress, and enhances cognitive performance. Clinical trials showed improved memory, focus, and stress-handling ability within 4 weeks of use.
Core Ingredients
Bifidobacterium longum 1714™ (5 Billion CFU)
-
Modulates brain activity and cortisol response
-
Supports cognitive performance and memory
-
Helps maintain mood balance under stress
-
Promotes gut microbial health and HPA axis regulation
Vitamin B6 (Pyridoxine Hydrochloride) – 0.85 mg (50% DV)
-
Supports neurotransmitter function
-
Essential for converting glutamate to GABA (calming pathway)
-
Involved in serotonin synthesis
Vitamin B12 (Hydroxocobalamin Acetate) – 1.2 mcg (50% DV)
-
Supports serotonin and dopamine pathways
-
Maintains homocysteine levels for brain health
-
Contributes to mood and energy regulation
Saffron Stigma Extract (Crocus sativus L.) – 14 mg
-
Helps support healthy mood, relaxation, and nervous system function
-
Clinically shown to reduce occasional low mood and emotional tension
Supplement Facts
Serving Size: 1 capsule
Servings Per Container: 60
| Ingredient | Amount | % Daily Value |
|---|---|---|
| Vitamin B6 (pyridoxine HCl) | 0.85 mg | 50% |
| Vitamin B12 (hydroxocobalamin) | 1.2 mcg | 50% |
| Bifidobacterium longum 1714™ | 5 Billion CFU | † |
| Saffron Extract (Crocus sativus L.) | 14 mg | † |
† Daily Value not established
Other Ingredients: Cellulose, vegetable capsule (cellulose and water), magnesium stearate, silicon dioxide
Free from: gluten, dairy, soy, GMOs, artificial preservatives
Shelf-stable, vegan-friendly
Suggested Use
Ages 8+: Take 1 capsule daily in the morning, with or without food, or as directed by your healthcare practitioner.
FAQ
Q: What is a psychobiotic?
A: A psychobiotic is a probiotic strain that positively influences the gut-brain axis and supports mood, stress resilience, and cognition.
Q: Can I take Zenbiome™ Cope with Zenbiome™ Sleep?
A: Yes. Zenbiome™ Cope is formulated for daytime stress support, while Zenbiome™ Sleep helps with nighttime relaxation and sleep quality. They work synergistically.
Q: How long before I notice results?
A: Clinical results with Bifidobacterium 1714™ were observed within 4 weeks. Continued use supports long-term balance.
Q: Is this a replacement for anxiety medication?
A: No. Zenbiome™ Cope is a dietary supplement intended to support occasional stress and mood balance. It is not a medication.
Zahler's Junior Melatonin provides 1 mg of sleep-enhancing Melatonin for children.
- Supports quality sleep
- Provides 1 mg Melatonin per tablet
- Delicious-tasting grape flavor
Zahler's Junior Melatonin provides 1 mg of sleep-regulating melatonin to support restful and quality sleep. Melatonin is a natural seep aid that the brain produces in response to darkness. Supplementing with additional Melatonin is a quick and easy sleep booster.
Suggested use
Children ages 4+ take 1 chewable tablet at bedtime or as directed by a healthcare practitioner.
You may need additional supplements to support a healthy diet; consult your nutritionist for a formula that is right for you.
Warnings
Keep out of reach of children. Do not use if safety seal is damaged or missing. If pregnant, nursing or on medication, consult with your healthcare practitioner.
Store tightly closed in a cool, dry place.
| Supplement facts | ||
| Serving Size: 1 Tablet | ||
| Servings Per Container: 120 | ||
| Amount Per Serving | %Daily Value for Adults and Children ≥ 4 Years | |
| Melatonin | 1 mg | * |
| * Daily Value not established. | ||
Warnings
Keep out of reach of children. Do not use if safety seal is damaged or missing. If pregnant, nursing or on medication, consult with your healthcare practitioner.
Store tightly closed in a cool, dry place.
Jarrow Formulas 5-HTP (5-Hydroxytryptophan) is an extract of Griffonia simplicifolia seeds from coastal West Africa. Purity is assured by HPLC. 5-HTP is the direct metabolic precursor to serotonin and is important for the production of melatonin, a hormone secreted by the pineal gland that aids biorhythm regulation.
- Help Support A Balanced Mood
- An Extract of Griffonia simplicifolia Seeds, the Direct Metabolic Precursor to Serotonin. 5-HTP is Important for the Production of Melatonin.
- 100 mg 5-HTP Per Serving
- Vegan, Non-GMO, Gluten Free
Suggested use
Adults take 1 capsule once a day on an empty stomach or as directed by your qualified healthcare professional.
WARNING: Consult a healthcare professional before using this product if you are pregnant, nursing, under the age of 18, are taking medication (especially if taking SSRIs, MAOs, or sedative medications) or have a medical condition; if adverse reactions occur, discontinue use.
Keep out of the reach of children.
| Supplement facts | ||
| Serving Size: 1 Capsule | ||
| Amount Per Serving | % DV | |
| 5-HTP (5-Hydroxytryptophan) (from Griffonia simplicifolia) (Seed) | 100 mg | † |
| † Daily Value (DV) not established. | ||
Other ingredients
Microcrystalline cellulose, capsule (hydroxypropylmethylcellulose, water), magnesium stearate (vegetable source) and silicon dioxide.
No wheat, gluten, soybeans, dairy, egg, fish/shellfish, peanuts/tree nuts or sesame.
Поддержка сна и общего самочувствия
Преимущества и особенности
Эта незаменимая альфа-аминокислота помогает вырабатывать белки и химические вещества для передачи сигналов в мозге, такие как нейромедиаторы серотонин и мелатонин.†
Подробный обзор
L-Триптофан — это незаменимая альфа-аминокислота, которая является предшественником нейромедиаторов серотонина и мелатонина. Многочисленные клинические исследования показали, что прием триптофана безопасен, хорошо переносится и способствует хорошему самочувствию, спокойствию, расслаблению, сну и контролю аппетита.† Для наилучшего результата принимайте триптофан натощак или с небольшой порцией углеводов.
СОСТАВ ДОБАВКИ
| Размер порции: 4 капсулы | ||
| Количество в 4 капсулах | % от суточной нормы | |
|---|---|---|
| L-Триптофан | 2,000 mg | * |
| * Суточная норма не установлена | ||
Другие ингредиенты:
Вегетарианская капсула (гидроксипропилметилцеллюлоза, вода), пальмитат аскорбила и микрокристаллическая целлюлоза.
Рекомендуемое применение
Взрослым: 2-4 капсулы перед сном или по рекомендации врача. Детям: по рекомендации врача.
Информация об аллергенах
Изготовлено без распространенных аллергенов: молоко/казеин, яйца, рыба, моллюски, орехи, арахис, пшеница, глютен, соя и кунжут. Без ГМО, веганский продукт, без синтетических красителей и ароматизаторов.
Предостережение
Проконсультируйтесь с врачом, если вы беременны или кормите грудью, имеете медицинское состояние или принимаете рецептурные препараты (включая антидепрессанты, такие как ИМАО и СИОЗС, а также седативные средства), или если вам меньше 18 лет. Может вызывать сонливость. Не используйте вместе с алкогольными напитками, а также перед управлением автомобилем или механизмами и во время этого. ХРАНИТЬ В НЕДОСТУПНОМ ДЛЯ ДЕТЕЙ МЕСТЕ.
FERMENTED MELATONIN
“PRL’s signature FermExcel-100 line is an industry first!”
- Fermented, probiotic-cultured melatonin
- Supports brain, sleep, and immune system health
- Promotes the unique antioxidant activity of melatonin
PRODUCT INFORMATION
Melatonin is a unique, complex molecule that is naturally present in virtually every cell of the body. Melatonin is considered to be the global master bioregulator of the whole body, intercoordinating many of the body’s complex systems, including quality sleep‚ brain support‚ the immune system‚ antioxidants‚ cardiovascular system‚ neuroendocrine system‚ bone health.* The levels of melatonin peak in one’s early years, then as the body ages, the biosynthesis of melatonin begins to decline drastically.
Premier Research Labs Melatonin-ND™ is a nutritional industry first, featuring melatonin in a convenient liquid form that has been cultured with beneficial probiotic organisms for active bio-availability. Melatonin-ND™ is not animal-derived so it is suitable for everyone, including vegetarians and vegans. This premier quality formula is fermented using a unique probiotic culture which allows rapid delivery and superior bioenergetic dynamics. Many people say they can feel the effect of this product the very first time they take it.
What is melatonin?
Melatonin is a unique immunomodulatory compound which supports a wide range of physiological functions. It is produced by the body’s pineal gland, a master gland located in the center of your brain. The secretion of melatonin is inhibited by light and stimulated by darkness. Therefore, melatonin production naturally rises at night. However, this may be compromised in individuals who have altered circadian rhythms or sleep patterns. The use of melatonin to promote restful sleep is well documented and has received substantial publicity for its ability to promote natural sleep patterns and maintain normal circadian rhythms. This extraordinary hormone is one of nature’s most effective antioxidants, offering unsurpassed protection against a broad range of free radicals which can cause cellular damage.
Are you enjoying restful nights and radiant days? If you need more help, then PRL’s Melatonin-ND™ is your product of choice. Experience an industry first with probiotic-fermented melatonin that promotes deep, restful, REM sleep.* You and your family will feel the PRL difference!
RECOMMENDED USAGE
Take 1 dropper just before sleep, or as directed by a health professional. Shake gently before use.
Supplement Facts
Serving Size 1 dropper (1 mL)
Servings Per Container about 54
Показано 32/64
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