Integrative Therapeutics

SUPPORTS A HEALTHY STRESS RESPONSE

WHAT IT DOES

Powerful adaptogenic herbs are combined to improve mood, create calm, reduce stress-related fatigue, and support cognitive function. By supporting homeostasis along the hypothalamic-pituitary-adrenal (HPA) axis, HPA Adapt helps maintain stress hormonal balance and a healthy stress response.

HOW IT WORKS

OPTIMIZING HPA AXIS FUNCTION

The body has a built-in system known as the hypothalamic-pituitary-adrenal (HPA) axis. The HPA axis helps maintain hormonal homeostasis even during times of mental, emotional, and/or physical stress. The HPA axis is designed to balance mood, energy levels, and cognition.*¹ Evidence from animal studies shows the HPA axis also helps support neurological, gastrointestinal, and immune function, suggesting it may influence other internal systems as the body copes with stress.*² By influencing HPA axis function, HPA Adapt is formulated to support stress hormone balance and a healthy stress response.*³

ADAPTOGENIC HERBS HELP MAINTAIN STRESS HORMONAL BALANCE*

HPA Adapt contains Rhodiola root extract, Sensoril® Ashwagandha root and leaf extract, eleuthero root extract, maca standardized extract, and standardized holy basil leaf extract. This formulation was designed to:

• Improve mood*
• Create calm*
• Reduce stress-related fatigue*
• Support cognitive function*

REFERENCES

1. Keller J et al. Molecular Psychiatry. 2017;22(4):527-536.
2. Farzi A, et al. Neurotherapeutics. 2018;15(1):5-22.
3. Auddy, B, et al. JANA Vol. 11, No. 1, 2008: 50-56.

DIRECTIONS

Other Ingredients 

Hydroxypropyl methylcellulose (vegetable capsule), ascorbyl palmitate, cellulose, silicon dioxide

Other Details

PROVIDES MAGNESIUM SUPPLEMENTATION

Provides magnesium supplementation for cardiovascular support and healthy muscular and neurological function.* Contains magnesium glycinate chelate for better tolerance.

DIRECTIONS

SUPPORTS A HEALTHY GASTROINTESTINAL LINING

Zinc Carnosine contains the PepZinGI brand of zinc-carnosine to support healthy gastrointestinal mucosa and relieve occasional mild gastric discomforts.* After years of development, a Japanese company produced PepZinGI®, a novel patented crystalline chelate compound consisting of L-carnosine and zinc.

The zinc-carnosine complex is typically dosed one 75 mg capsule twice per day. This provides 16 mg of elemental zinc twice daily.

PepZin GI® is a registered trademark of Hamari Chemicals USA, Inc

DIRECTIONS

Active B-Complex

B-VITAMINS PLAY ESSENTIAL ROLES IN MANY FUNCTIONS OF THE BODY

Optimal folate and B vitamin intakes are associated with healthy neurological function as well as cardiovascular support.*^1,2 Each B-vitamin exists in multiple forms, often referred to as vitamers. Active forms of vitamers are those that can be directly utilized by the body immediately. Active B-Complex features a potent blend containing the active forms of Vitamins B2, B6, B12, as well as Quatrefolic®-branded methylfolate (the bioactive form of folate). Free from top 8 allergens.

HOW IT WORKS

B-vitamins play essential roles in many functions of the body. Vitamin B1 (as Thiamin) and Vitamin B2 (Riboflavin as riboflavin-5'-phosphate) serve as coenzymes essential for cell function, growth and energy production.*¹ Vitamin B6 (as pyridoxal-5-phosphate and pyridoxine HCl) has an essential role in the synthesis of neurotransmitters, including serotonin, dopamine and gamma-aminobutyric acid (GABA).*³ Folate has essential roles in nervous system and immune system function.*^1,4 Vitamin B12 (as methylcobalamin) is essential for nervous system function, playing particular roles in myelin synthesis and nerve metabolism.*⁵

REFERENCES

1. Kennedy DO et al. Nutrients. 2016;8(2):68.
2. Wald DS et al. BMJ. 2002;325(7374):1202.
3. Stover PJ et al. Adv Nutr. 2015;6(1):132-3.
4. Maggini S et al. Nutrients. 2018;10(10):1531.
5. Calderon-Ospina CA et al. CNS Neurosci Ther. 2020;26(1):5-13.

DIRECTIONS

PROVIDES CARDIOVASCULAR AND BONE SUPPORT

K2 + D3 provides cardiovascular and bone support with clinically studied MenaQ7® vitamin K2 plus high potency vitamin D3.* The two vitamins complement one another to help the body absorb and use calcium for healthy bone support.* Vitamin K2 helps transport calcium away from the blood vessels by decreasing levels of the inactive form of Matrix Gla-Proteins (MGPs).* Active MGPs bind calcium in the blood and support healthy calcium deposition in bones.* (MenaQ7® is a registered trademark of Lesaffre et Compagnie, France.)

DIRECTIONS

METABOLIC SUPPORT

WHAT IT DOES

Berberine offers metabolic support for glucose and lipid metabolism.* It also supports healthy blood sugar and insulin levels already within a normal range.*

HOW IT WORKS

Clinical studies demonstrate that berberine supports healthy lipid metabolism and cholesterol homeostasis.*^1-6 Berberine can activate an important metabolic enzyme known as adenosine monophosphate-activated protein kinase (AMPK), a central regulator of cellular energy homeostasis.* Mechanistic research in vitro and in vivo suggests that berberine can decrease cholesterol and triglyceride synthesis by activating AMPK.^7-9

In addition to supporting lipid metabolism, berberine supports healthy glucose metabolism and blood sugar management already within a normal range.*^2-5 Mechanistic research in vitro suggests that berberine can support healthy glucose regulation through promoting glucose uptake in cells via GLUT4 translocation.⁷

REFERENCES

1. Kong W et al. Nat Med. 2004;10(12):1344-51.
2. Yin J et al. Metabolism. 2008;57(5):712-7.
3. Zhang Y et al. J Clin Endocrinol Metab. 2008;93(7):2559-2565.
4. Yang J et al. Evid Based Complement Alternat Med. 2012;2012:363845.
5. Perez-Rubio K et al. Metab Syndr Relat Disord. 2013;11(5):366-9.
6. Cao C et al. Exp Ther Med. 2019;17(4):3009-3014.
7. Lee YS et al. Diabetes. 2006;55:2256-64.
8. Brusq JM et al. J Lipid Res. 2006;47(6):1281-8.
9. Jiang D et al. Lipids Health Dis. 2016;15:214.

DIRECTIONS

Ingredients

plant-derived capsule (hypromellose), cellulose, calcium laurate, silica

FAQS

Pure Omega Ultra HP

WHAT IT DOES

PROVIDES ESSENTIAL OMEGA-3 FATTY ACIDS

Pure Omega products provide a triglyceride form of omega-3 fatty acids sustainably sourced from anchovies.

Every lot of Pure Omega is tested for purity and labeled potency claims. The results of these tests are available to you using the lot number found on each bottle. Check your product purity here.

HOW IT WORKS

EPA & DHA HELP SUPPORT ESSENTIAL FUNCTIONS*

Omega-3 essential polyunsaturated fatty acids have distinct chemical structures and physiologic functions that distinguish them from other families of essential fatty acids. Often lacking in Western diets, omega-3 fatty acids compete with other fatty acids in the body for cyclooxygenase (COX) and lipoxygenase (LOX) enzyme metabolism, incorporation into cell membranes, and the synthesis of lipid mediators.^1-3 The long-chain omega-3 fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are almost exclusively marine-derived and act together to influence membrane fluidity and signal transduction pathways.⁴

EPA and DHA are abundantly enriched in the retina, brain, and heart tissues.^5-7 Each have preferential distribution within the phospholipid bilayer of cell membranes and have been shown to exert unique biological actions.⁴

Humans have limited capacity to endogenously produce EPA and DHA; therefore they are considered essential fatty acids. Dietary supplementation of EPA and DHA is an effective way to increase intake of these essential fatty acids.

REFERENCES

1. Simopoulos AP. J Am Coll Nutr. 2002;21(6):495-505.
2. Surette ME. CMAJ. 2008;178(2):177-180.
3. Calder PC. Br J Clin Pharmacol. 2013;75(3):645-662.
4. Mason RP. Curr Atheroscler Rep. 2019;21:2.
5. Jeffrey BG et al. Lipids. 2001;36(9):859-71.
6. Kim HY et al. Prog Lipid Res. 2015;0:1-18.
7. Jump DB et al. J Lipid Res. 2012;53(12):2525-45.

DIRECTIONS

Pure Omega HP

WHAT IT DOES

PROVIDES ESSENTIAL OMEGA-3 FATTY ACIDS

Pure Omega products provide a triglyceride form of omega-3 fatty acids sustainably sourced from anchovies, sardines, herring, tuna, and mackerel.

Every lot of Pure Omega is tested for purity and labeled potency claims. The results of these tests are available to you using the lot number found on each bottle. Check your product purity here.

HOW IT WORKS

EPA & DHA HELP SUPPORT ESSENTIAL FUNCTIONS*

Omega-3 essential polyunsaturated fatty acids have distinct chemical structures and physiologic functions that distinguish them from other families of essential fatty acids. Often lacking in Western diets, omega-3 fatty acids compete with other fatty acids in the body for cyclooxygenase (COX) and lipoxygenase (LOX) enzyme metabolism, incorporation into cell membranes, and the synthesis of lipid mediators.^1-3 The long-chain omega-3 fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are almost exclusively marine-derived and act together to influence membrane fluidity and signal transduction pathways.⁴

EPA and DHA are abundantly enriched in the retina, brain, and heart tissues.^5-7 Each have preferential distribution within the phospholipid bilayer of cell membranes and have been shown to exert unique biological actions.⁴

Humans have limited capacity to endogenously produce EPA and DHA; therefore they are considered essential fatty acids. Dietary supplementation of EPA and DHA is an effective way to increase intake of these essential fatty acids.

REFERENCES

1. Simopoulos AP. J Am Coll Nutr. 2002;21(6):495-505.
2. Surette ME. CMAJ. 2008;178(2):177-180.
3. Calder PC. Br J Clin Pharmacol. 2013;75(3):645-662.
4. Mason RP. Curr Atheroscler Rep. 2019;21:2.
5. Jeffrey BG et al. Lipids. 2001;36(9):859-71.
6. Kim HY et al. Prog Lipid Res. 2015;0:1-18.
7. Jump DB et al. J Lipid Res. 2012;53(12):2525-45.