1-MNA + Apigenin 30 capsules nuBioAge

Overview

1-MNA + Apigenin 30 Capsules by nuBioAge is an advanced dual-ingredient supplement formulated to support vascular health, NAD+ metabolism, cellular energy, and healthy aging. Each vegetarian capsule combines 250 mg of 1-MNA (1-methylnicotinamide chloride) with 150 mg of apigenin standardized to 98%.

The formula brings together two compounds associated with complementary biological pathways. 1-MNA is a naturally occurring metabolite of nicotinamide investigated for its relationship with vascular function, circulation, and inflammatory signaling. Apigenin is a naturally occurring plant flavonoid studied for its ability to influence CD38, an enzyme involved in the metabolism and breakdown of NAD+.

By combining vascular and metabolic support with ingredients associated with NAD+ preservation, nuBioAge offers a targeted formula for adults interested in cellular resilience, healthy longevity, and maintaining normal physiological function with age.

Each bottle contains 30 vegetarian capsules, providing 30 daily servings or a one-month supply when taken as directed.

Key Benefits

• Provides 250 mg of 1-MNA per capsule
• Contains 150 mg of apigenin standardized to 98% purity
• Supports healthy vascular function and circulation
• Supports normal endothelial function and vascular wellness
• Features compounds investigated for their roles in NAD+ metabolism
• Apigenin is studied for its ability to inhibit CD38 activity
• Supports cellular health and normal energy metabolism
• Supports a balanced inflammatory response
• Provides antioxidant-related cellular support through apigenin
• Combines two complementary compounds in one capsule
• Designed for healthy aging and longevity-focused nutritional routines
• Convenient once-daily serving
• Vegetarian capsule formulation
• 30 capsules per bottle

Supplement Facts

Serving Size: 1 Capsule

Servings Per Container: 30

† Daily Value (DV) not established.

Other Ingredients: Hypromellose (vegetable capsule), microcrystalline cellulose, magnesium stearate, silicon dioxide.

Ingredient Breakdown

How 1-MNA + Apigenin Works

The concept behind nuBioAge 1-MNA + Apigenin is to combine compounds involved in two interconnected areas of healthy aging: vascular function and NAD+ metabolism.

1-MNA is formed naturally during the metabolism of nicotinamide, a form of vitamin B3. This metabolite has been investigated for its biological activity in vascular tissues, including pathways related to endothelial signaling and inflammatory responses.

Apigenin is a bioactive flavonoid found in various plants. Laboratory research has investigated its ability to inhibit CD38, an enzyme that consumes NAD+ during normal cellular metabolism.

NAD+ is an essential coenzyme involved in cellular energy production, metabolic reactions, and cellular signaling. Because NAD+ availability is connected with numerous aspects of cell function, the enzymes responsible for its production and consumption are important research targets.

Combining 1-MNA and apigenin offers a nutritional approach focused on vascular wellness alongside NAD+-related cellular pathways. However, the clinical effects of this exact combination have not been established through the product information supplied by the manufacturer.

What Is 1-MNA?

1-MNA, also known as 1-methylnicotinamide or N1-methylnicotinamide, is a naturally occurring metabolite formed during nicotinamide metabolism.

In the body, nicotinamide N-methyltransferase (NNMT) participates in converting nicotinamide into 1-MNA. The compound can then undergo further metabolism into downstream metabolites.

Although 1-MNA is produced during vitamin B3 metabolism, it is not the same compound as nicotinamide, nicotinamide riboside (NR), or nicotinamide mononucleotide (NMN).

Scientific interest in 1-MNA includes its potential biological activity beyond its role as a metabolic intermediate. Experimental and clinical research has examined associations with endothelial function, vascular physiology, prostacyclin-related signaling, and inflammatory pathways.

These areas make 1-MNA of interest to researchers studying cardiovascular wellness, cellular metabolism, and healthy aging.

1-MNA and Vascular Health

The vascular endothelium is a thin layer of cells lining the interior surface of blood vessels. It plays an important role in maintaining vascular tone, normal circulation, and communication between the bloodstream and surrounding tissues.

Healthy endothelial function is supported by complex signaling pathways that help regulate vessel relaxation, blood flow, and normal vascular responses.

1-MNA has been investigated for its involvement in vascular biology, including pathways associated with endothelial signaling and prostacyclin activity.

Prostacyclin is a naturally occurring signaling molecule involved in the regulation of vascular tone and platelet function. Research into 1-MNA has explored how this metabolite may interact with related vascular processes.

nuBioAge includes 250 mg of 1-MNA per capsule as the vascular-support component of the formula.

Important: This supplement is intended for nutritional support and is not a substitute for prescribed cardiovascular medication or medical treatment.

What Is Apigenin?

Apigenin is a naturally occurring flavonoid found in several plants and foods.

Dietary sources of apigenin include:

• Parsley
• Chamomile
• Celery
• Various herbs and plant foods

Apigenin belongs to the flavone subclass of flavonoids and has been studied for its antioxidant-related properties and interactions with cellular signaling pathways.

One area of particular interest is its potential influence on CD38, an enzyme involved in NAD+ consumption.

nuBioAge uses 150 mg of apigenin standardized to 98% per capsule. This provides a clearly identified quantity of the active flavonoid rather than relying on an unspecified amount from a general botanical extract.

Apigenin and CD38 Inhibition

CD38 is an enzyme involved in several biological processes, including the metabolism of NAD+ and the generation of signaling molecules.

Because CD38 consumes NAD+, its activity is relevant to research exploring cellular NAD+ availability and metabolism.

Experimental studies have identified apigenin as a compound capable of inhibiting CD38 activity under certain laboratory conditions.

This has led to interest in apigenin as a potential nutritional ingredient for supporting NAD+-related biological pathways.

However, it is important to distinguish laboratory findings from proven effects in humans. The ability of oral apigenin supplementation at a particular dose to meaningfully inhibit CD38 or preserve NAD+ in humans has not been conclusively established.

The manufacturer positions apigenin as the NAD+ preservation component of this formula, complementing the vascular-related activity of 1-MNA.

Understanding NAD+ and Cellular Energy

NAD+, or nicotinamide adenine dinucleotide, is an essential coenzyme found throughout the body.

It participates in oxidation-reduction reactions that help cells convert nutrients into usable energy and supports numerous other cellular functions.

NAD+ is also used by enzymes involved in cellular signaling and maintenance, including certain sirtuins, PARPs, and CD38.

Normal NAD+ metabolism depends on maintaining a balance between its synthesis, recycling, and consumption.

Research into healthy aging increasingly examines how these processes change with age and how they interact with mitochondrial function, metabolic regulation, and cellular resilience.

Rather than providing NMN or NR directly, nuBioAge 1-MNA + Apigenin features compounds associated with vascular biology and NAD+ metabolism through different pathways.

NAD+ Preservation vs. NAD+ Precursor Supplementation

Not all supplements marketed for NAD+ support work through the same biological mechanisms.

NAD+ precursors, such as NMN and nicotinamide riboside, participate in pathways that the body uses to synthesize NAD+.

CD38-related approaches focus on enzymes involved in NAD+ consumption. Apigenin is of interest in this category because laboratory research has investigated its effects on CD38 activity.

1-MNA is different from both categories. It is a metabolite of nicotinamide with biological activity investigated in vascular and metabolic research.

These compounds have different biochemical characteristics and should not be considered interchangeable on a milligram-for-milligram basis.

1-MNA, Apigenin, and Healthy Aging

Healthy aging involves maintaining the function of interconnected physiological systems, including the cardiovascular system, cellular energy pathways, and the body's ability to respond to normal metabolic demands.

The ingredients in nuBioAge 1-MNA + Apigenin reflect two areas of interest in longevity research:

• Vascular resilience: maintaining normal endothelial function and circulation.
• Cellular metabolism: understanding and supporting biological pathways associated with NAD+ availability.

The formula is designed for adults interested in nutritional support for these systems as part of an overall healthy lifestyle.

Although 1-MNA and apigenin are subjects of scientific investigation, current evidence does not establish that taking this combination extends human lifespan or reverses biological aging.

Antioxidant and Inflammatory Response Support

Oxidative stress and inflammatory signaling are normal parts of cellular physiology. Maintaining an appropriate balance is important for healthy tissue function.

Apigenin has been studied for its interactions with antioxidant-related and inflammatory signaling pathways.

1-MNA has also been investigated for biological activity relevant to vascular and inflammatory responses.

These properties are part of the scientific rationale for combining the ingredients, although the degree to which the finished product influences these pathways in humans has not been established.

Why Choose 1-MNA + Apigenin by nuBioAge?

Unlike single-ingredient formulations, nuBioAge 1-MNA + Apigenin combines two clearly dosed compounds that participate in different aspects of cellular physiology.

The formula provides:

• 250 mg 1-MNA: a naturally occurring nicotinamide metabolite studied in vascular and metabolic research.
• 150 mg apigenin (98%): a standardized plant flavonoid investigated for CD38-related activity.
• One-capsule daily serving: a convenient format for consistent supplementation.
• Vegetarian capsule: made with plant-derived hypromellose.
• Transparent Supplement Facts: individual ingredient amounts are provided rather than hidden in a proprietary blend.

The combination is particularly relevant to adults who want to explore longevity-focused nutritional support beyond conventional vitamin and mineral products.

Who Is It For?

nuBioAge 1-MNA + Apigenin may be suitable for adults interested in:

• Healthy aging and longevity-focused nutrition
• Normal vascular and endothelial function
• Healthy circulation
• Cellular energy metabolism
• NAD+ metabolism and NAD+ preservation research
• CD38-related cellular signaling pathways
• Antioxidant and inflammatory response support
• Combining 1-MNA and apigenin in one supplement
• A vegetarian capsule with clearly specified ingredient quantities
• A convenient once-daily cellular wellness routine

Suggested Use

Adults: Take 1 capsule daily, or as directed by a healthcare professional.

Each capsule provides:

• 1-MNA: 250 mg
• Apigenin (98%): 150 mg

One bottle contains 30 capsules, providing a 30-day supply at the recommended daily intake.

Caution

Consult a healthcare professional before use if you are pregnant, breastfeeding, taking prescription medications, or have a medical condition.

Individuals taking medications that affect blood pressure, circulation, or blood clotting should discuss the use of this supplement with their healthcare provider.

Do not exceed the recommended serving without professional guidance. Discontinue use if an adverse reaction occurs.

This formula is intended for adult use. Keep out of reach of children.

Product Specifications

Frequently Asked Questions

What is nuBioAge 1-MNA + Apigenin?

It is a dual-ingredient dietary supplement containing 250 mg of 1-methylnicotinamide and 150 mg of apigenin per capsule, formulated for vascular support, NAD+ metabolism, and healthy aging.

How much 1-MNA is in each capsule?

Each capsule contains 250 mg of 1-MNA as 1-methylnicotinamide chloride.

How much apigenin is in each capsule?

Each capsule contains 150 mg of apigenin standardized to 98%.

What is 1-MNA?

1-MNA, or 1-methylnicotinamide, is a naturally occurring metabolite formed during nicotinamide metabolism. It has been investigated for its involvement in vascular function and cellular signaling.

Is 1-MNA the same as NMN?

No. 1-MNA and NMN are different compounds. NMN is an NAD+ precursor, while 1-MNA is a methylated metabolite of nicotinamide.

Does 1-MNA directly increase NAD+?

1-MNA is not a conventional NAD+ precursor like NMN or nicotinamide riboside. Its biological effects are investigated primarily in relation to nicotinamide metabolism, vascular function, and cellular signaling.

What is apigenin?

Apigenin is a naturally occurring plant flavonoid found in foods and herbs such as parsley, chamomile, and celery. It is studied for its antioxidant-related properties and cellular signaling activity.

What is CD38?

CD38 is an enzyme involved in NAD+ metabolism and cellular signaling. It is one of the enzymes that consume NAD+ in the body.

Does apigenin inhibit CD38?

Laboratory research has identified apigenin as a CD38 inhibitor under certain experimental conditions. Whether oral supplementation at the amount in this product significantly inhibits CD38 in humans remains to be established.

What does NAD+ preservation mean?

NAD+ preservation refers to supporting the balance between NAD+ production and consumption. The manufacturer associates apigenin with this concept because of its investigated effects on CD38 activity.

Does this product contain NMN or NR?

No. The two labeled active ingredients are 1-MNA and apigenin. The formula does not list NMN or nicotinamide riboside.

Can this supplement support circulation?

The manufacturer positions 1-MNA as an ingredient for healthy vascular function and circulation. Research into its biological activity is ongoing, and the supplement is not intended to treat circulatory disorders.

Does this formula support healthy aging?

The formula is designed around biological pathways relevant to vascular wellness and NAD+ metabolism. However, it has not been established that this combination extends human lifespan or prevents age-related disease.

Does 1-MNA + Apigenin provide immediate energy?

The ingredients are associated with metabolic and cellular signaling pathways rather than immediate stimulation. This is not a caffeine-based energy supplement.

Is this product suitable for vegetarians?

The supplement uses a vegetable capsule made from hypromellose. The supplied label does not identify any animal-derived ingredients.

How many capsules are in one bottle?

Each bottle contains 30 capsules.

How many servings are in one bottle?

Each bottle provides 30 servings.

How long does one bottle last?

At the recommended intake of one capsule daily, a bottle lasts 30 days.

How should I take 1-MNA + Apigenin?

The manufacturer's suggested use is one capsule daily.

Can I combine this product with NAD+ supplements?

The formula contains ingredients related to NAD+ metabolism, but evidence establishing the safety or added benefits of combining it with NMN, NR, or other NAD+-focused supplements is limited. Consult a healthcare professional before combining them.

Is apigenin the same as chamomile extract?

No. Apigenin is a specific flavonoid that occurs naturally in chamomile and other plants. A standardized apigenin supplement provides a defined quantity of the compound, unlike a general chamomile extract.

Are 1-MNA and apigenin equally dosed?

No. Each capsule contains 250 mg of 1-MNA and 150 mg of apigenin.

Does the formula contain a proprietary blend?

No. Both active ingredient quantities are individually disclosed on the Supplement Facts label.

What are the other ingredients?

The other ingredients are hypromellose (vegetable capsule), microcrystalline cellulose, magnesium stearate, and silicon dioxide.

Is the supplement intended for children?

The product is presented as an adult wellness supplement. Use in children should only occur under the direction of an appropriately qualified healthcare professional.

Who should consult a healthcare professional before use?

Pregnant or breastfeeding individuals, people with medical conditions, and those taking prescription medications should consult a healthcare professional before using this supplement.

Storage

Store in a cool, dry place away from excessive heat, humidity, and direct sunlight. Keep the bottle tightly closed and out of reach of children. Do not use if the safety seal is damaged or missing.

Disclaimer: This product is intended for nutritional support and is not intended to diagnose, treat, cure, or prevent any disease. Information about individual ingredients and their biological pathways does not establish clinical efficacy for the finished combination.