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Jarrow Formulas® Methyl B-12 & Methyl Folate plus Pyridoxal-5-Phosphate (P5P) combines the biologically active coenzyme forms of vitamin B12, B9 and B6 that support cellular energy metabolism and neurotransmitter synthesis.* This combination supports the recycling of homocysteine to methionine to support cardiovascular health.
- Provides Methyl B-12 plus Methyl Folate and Pyridoxal 5-Phosphate in a Convenient Chewable Tablet Form
- Cellular Energy Metabolism and Cardiovascular Health*
- 1000 mcg Methyl B-12 and 400 mcg Methyl Folate per serving
- Lemon and Other Natural Flavors Chewable Tablet
- Methylcobalamin (Methyl B-12) and Methyl Folate are biologically active forms of vitamin B12 and B9*
- Methyl Folate is unlike synthetic folic acid that may mask vitamin B12 deficiency*
- Pyridoxal 5-Phosphate (P-5-P) Is the Coenzyme Form of Vitamin B6*
- Vegan, Non-GMO, Gluten Free
Suggested use
Adults take 1 chewable tablet once a day or as directed by your qualified healthcare professional.
WARNING: Consult a healthcare professional before using this product if you are pregnant, nursing, under the age of 18, are taking medication (especially antiepileptic and chemotherapy) or have a medical condition; if adverse reactions occur, discontinue use.
| Supplement facts | ||
| Serving Size: 1 Tablet | ||
| Amount Per Serving | %DV | |
| Vitamin B6 (as Pyridoxal-5-Phosphate) | 1.5 mg | 88% |
| Folate (400 mcg as (6S)-5-MTHF [from (6S)-5-Methyltetrahydrofolate Glucosamine Salt]) | 680 mcg DFE‡ | 170% |
| Vitamin B12 (as Methylcobalamin) | 1,000 mcg | 41,667% |
| ‡Dietary Folate Equivalents. | ||
Other ingredients
Xylitol, microcrystalline cellulose, stearic acid (vegetable source), natural flavor, citric acid, magnesium stearate (vegetable source), silicon dioxide and rebaudioside A (stevia extract).
No wheat, gluten, soybeans, dairy, egg, fish/shellfish, peanuts/tree nuts or sesame.
Keep out of the reach of children.
Methyl Folate ((6S)-5-methyltetrahydrofolate or (6S)-5-MTHF) is a highly biologically active form of folate.* Due to the body’s limited ability to transform synthetic folic acid into the active form of folate, supplementation with 5-MTHF is highly preferable.
- Biologically Active Folate (Methyl Folate [5-MTHF])
- Quatrefolic®: 4th Generation Development in Folate Delivery
- Increased Stability & Bioavailability
Suggested use
Adults take 1 capsule once a day with or without food or as directed by your qualified healthcare professional.
WARNING: Consult a healthcare professional before using this product if you are pregnant, nursing, under the age of 18, are taking medication (especially antiepileptic and chemotherapy) or have a medical condition; if adverse reactions occur, discontinue use.
Keep out of the reach of children.
| Supplement facts | ||
| Serving Size: 1 Capsule | ||
| Amount Per Serving | % DV | |
| Folate (1,000 mcg as (6S)-5-MTHF [from (6S)-5-Methyltetrahydrofolate Glucosamine Salt]) |
1,700 mcg DFE‡ | 425% |
| ‡Dietary Folate Equivalents. | ||
Other ingredients
Microcrystalline cellulose, capsule (hydroxypropylmethylcellulose, water) and magnesium stearate (vegetable source).
No wheat, gluten, soybeans, dairy, egg, fish/shellfish, peanuts/tree nuts or sesame.
Promotes heart, brain & GI tract health
Our BioActive Folate & Vitamin B12 includes biologically active forms of folate and vitamin B12 to promote heart, brain and GI tract health.
What Is BioActive Folate & Vitamin B12?
BioActive Folate & Vitamin B12 supports the heart, brain, GI tract and more because its capsules contain the clinically studied, biologically active forms of folate (as 5-methyltetrahydrofolate) and vitamin B12 (as methylcobalamin).
BioActive Folate & Vitamin B12 capsules use clinically studied forms of folate and vitamin B12 to maximize benefits.
BioActive Folate & Vitamin B12 Benefits
- Supports heart health & already normal homocysteine levels
- Promotes nerve cell growth, brain health, cognition & metabolism
- Helps maintain a healthy GI tract
- Supports a healthy immune system & nervous system function
- Helps maintain production of red blood cells within normal range
The Variety of Vitamin B
The vitamin B family is much more complex than most people realize, and it also offers numerous health benefits. With this in mind, Life Extension formulated BioActive Folate & Vitamin B12 with some of the most biologically active forms of folate and vitamin B12 to maximize benefits for the heart, brain and GI tract.
More facts about BioActive Folate & Vitamin B12
BioActive Folate & Vitamin B12 capsules contain the biologically active forms of folate (as 5-methyltetrahydrofolate) and vitamin B12 (as methylcobalamin).
5-methyltetrahydrofolate (5-MTHF) is the metabolically active form of folic acid. It’s the only form of folate used directly by the body and does not require metabolic conversion or activation. 5-MTHF is up to seven times more bioavailable than folic acid.1 5-MTHF can cross the blood-brain barrier, which allows 5-MTHF specifically to benefit the neurological system.
Methylcobalamin is the bioactive form of B12 that is readily utilized in the body and central nervous system.
What Folate Does for the Body
Folate is a member of the B-complex family. It is found in abundance in leafy green vegetables. Folate participates in an enzymatic reaction that synthesizes DNA needed for cell growth and new cell formation, and it helps convert vitamin B12 to one of its bioactive forms.
Folate provides many health benefits, including helping to promote healthy DNA function, maintaining already normal homocysteine levels for heart health, promoting healthier skin, and helping to maintain a healthy GI tract and immune system. It also maintains healthy endothelial function and may improve mild memory loss associated with aging.
Optimal levels of folate are necessary for healthy cell division and protein synthesis and are especially important for the maintenance of a healthy GI tract. Chronic use of medications such as aspirin in therapeutic doses and antacids can interfere with the metabolism of folate.
The Impact of Vitamin B12
Vitamin B12 is found in foods of animal origin, including dairy products and eggs. Thus, vegetarians are more susceptible to a dietary deficiency of this important nutrient. With aging, absorption of vitamin B12 from dietary sources typically declines.
Benefits of vitamin B12 include supporting brain health and cognition, and supporting heart health by regenerating the amino acid methionine, which helps maintain healthy homocysteine levels. B12 also helps enhance methylation and promote nerve cell growth, brain health, cognition and metabolism. And when combined with folate, it helps maintain the production of red blood cells (erythropoiesis) within normal range.
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| Dosage and Use | ||||||||||||
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- KEEP OUT OF REACH OF CHILDREN
- DO NOT EXCEED RECOMMENDED DOSE
- Do not purchase if outer seal is broken or damaged.
- When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.
Active B12-Folate 60 tablets by SFI Health are fast-dissolving tablets featuring methylfolate and methylcobalamin. The formula is designed to support red blood cell function, energy metabolism, and brain, vascular, mood, and nervous system function.
Each package contains 60 tablets. The formula uses folate as Metafolin® calcium L-5-methyltetrahydrofolate and Vitamin B12 as methylcobalamin in a form intended to be easy to digest, absorb, and use.
Key Benefits
- Supports red blood cell function and energy metabolism
- Supports brain, vascular, and nervous system function
- Promotes healthy mood†
- Uses fast-dissolving tablets
- Provides methylfolate and methylcobalamin
Ingredient Breakdown
| Ingredient or Feature | Role in the Formula |
|---|---|
| Folate as Metafolin® calcium L-5-methyltetrahydrofolate | Supports red blood cell function, energy metabolism, and brain, vascular, mood, and nervous system function. |
| Vitamin B12 as methylcobalamin | Supports red blood cell function, energy metabolism, and brain, vascular, mood, and nervous system function. |
| Fast-dissolving tablet format | Designed to dissolve in the mouth and provide a form that is easy to digest, absorb, and use. |
How It Works
Methylfolate and methylcobalamin complement one another in a formula designed to support red blood cell function, energy metabolism, and the brain, vascular, mood, and nervous systems. The fast-dissolving tablet format is intended to dissolve in the mouth and can be chewed if desired.
Suggested Use
Adults: 1 lozenge daily as needed or as directed by a healthcare professional. Dissolve in the mouth and swallow, or chew if desired. Children: As directed by a healthcare professional
Caution
Consult with your physician if you are pregnant or nursing, or have any medical conditions, or taking prescription drugs, or under the age of 18 years. KEEP OUT OF REACH OF CHILDREN.
Quality & Dietary Attributes
- Vegan
- Made without common allergens: milk/casein, eggs, fish, shellfish, tree nuts, peanuts, sesame, and soybeans
- No artificial colors, flavors, or preservatives
- Contains bioengineered ingredient
Frequently Asked Questions
What is Active B12-Folate 60?
It is a SFI Health tablet formula featuring methylfolate and methylcobalamin to support red blood cell function, energy metabolism, and neurological health.
Which ingredients are featured?
The formula features folate as Metafolin® calcium L-5-methyltetrahydrofolate and Vitamin B12 as methylcobalamin.
How should adults use it?
Adults should take 1 lozenge daily as needed or as directed by a healthcare professional. It may be dissolved in the mouth and swallowed, or chewed if desired.
Is it vegan?
Yes. The source identifies the product as vegan.
What package size is available?
The available package contains 60 tablets.
†These statements reflect the manufacturer selling points supplied for this product. Metafolin® is a registered trademark of Merck KGaA, Darmstadt, Germany.
Methyl Folate ((6S)-5-methyltetrahydrofolate or (6S)-5-MTHF) is a highly biologically active form of folate.* Due to the body’s limited ability to convert synthetic folic acid into the active form of folate, supplementation with (6S)-5-MTHF is preferable.
- A Highly Bioactive Form Of Folate
- Quatrefolic®
- Increased Stability & Bioavailability
- Extra Strength, 400mcg of Folate Per Serving
Suggested use
Adults take 1 capsule once a day with or without food or as directed by your qualified healthcare professional.
WARNING: Consult a healthcare professional before using this product if you are pregnant, nursing, under the age of 18, are taking medication (especially antiepileptic and chemotherapy) or have a medical condition; if adverse reactions occur, discontinue use.
| Supplement facts | ||
| Serving Size: 1 Capsule | ||
| Amount Per Serving | %DV | |
| Folate (400 mcg as (6S)-5-MTHF [(6S)-5-Methyltetrahydrofolate Glucosamine Salt) | 680 mcg DFE‡ | 170% |
| ‡Dietary Folate Equivalents. | ||
Other ingredients
Microcrystalline cellulose capsule (hydroxypropylmethylcellulose, water) and magnesium stearate (vegetable source).
No wheat, gluten, soybeans, dairy, egg, fish/shellfish, peanuts/tree nuts or sesame.
Keep out of the reach of children.
Our Optimized Folate formula promotes both cardiovascular and cognitive health with 1,700 mcg of folate in the form of 5-MTHF, the metabolically active form of folic acid.
What Is Optimized Folate?
Maintaining normal levels of homocysteine, a metabolic byproduct, is associated with both cardiovascular and cognitive health. The B vitamin folate helps maintain already healthy homocysteine levels. The RDA for folate for adults is 400 mcg a day. Our formula provides 1,700 mcg of folate in the form of L-Methylfolate.
Help maintain already healthy levels of the health biomarker homocysteine with 1,700 mcg of folate a day.
Optimized Folate Benefits
- Supports both cardiovascular & cognitive health
- Helps maintain already-healthy homocysteine levels
- Delivers 1,700 mcg of the B vitamin folate
Folate, homocysteine & cardiovascular health
Folate helps maintain healthy homocysteine levels already within the normal range. By helping to inhibit excess homocysteine, folate supports healthy levels of this important cardiovascular health biomarker.
5-MTHF, homocysteine & cognitive health
Since people with elevated homocysteine levels have a greater risk of cognitive decline, getting enough folate is especially crucial for aging individuals attempting to maintain cognitive health.
Take alone or with B12 for enhanced effect
The RDA for folate for non-pregnant or lactating adults is 400 mcg a day. This formula delivers 1,700 mcg of 5-MTHF folate. If you’re looking for a higher dose, try our High Potency Optimized Folate formula, which delivers 8,500 mcg of 5-MTHF. You can combine either formula with vitamin B12 in the form of methylcobalamin, vitamin B6 in either the pyridoxal 5’-phosphate or pyridoxine hydrochloride form, and/or riboflavin.
° DFE (dietary folate equivalents) Non-GMO |
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| Dosage and Use | ||||||||
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| Caution | ||||||||
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Consult your healthcare provider if you are at risk of vitamin B12 deficiency, as high-dose folate may mask signs. |
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- KEEP OUT OF REACH OF CHILDREN
- DO NOT EXCEED RECOMMENDED DOSE
- Do not purchase if outer seal is broken or damaged.
- When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.
L-Methylfolate 8500 mcg DFE, 30 vegetarian tablets
Heart & brain health, homocysteine support, strong dose
Our High Potency Optimized Folate is a cardiovascular health supplement that also supports cognitive health and more with 8500 mcg of metabolically active 5-MTHF.
What is High Potency Optimized Folate?
Maintaining normal levels of homocysteine, a metabolic byproduct, is associated with both cardiovascular and cognitive health. Folate, a B vitamin, helps maintain homocysteine levels already within normal range. However, not everyone can efficiently convert folate to its biologically active form. Our formula provides 5-MTHF, so you don’t have to.
The 5-MTHF folate in High Potency Optimized Folate is an ultra-bioavailable form of the B-vitamin commonly called folic acid.
High Potency Optimized Folate Benefits
- Super high-potency dose of bioavailable 5-MTHF folate
- Supports both cardiovascular & cognitive health
- Helps maintain already-healthy homocysteine levels
- 5-MTHF folate overcomes the enzyme inefficiency roadblock
For the Greatest Health Benefits
Folic acid is a common B-vitamin supplement. Once ingested, your body is supposed to convert folic acid into 5-methyltetrahydrofolate, or 5-MTHF. But research shows that many people lack sufficient activity of the enzyme that’s necessary to do this. So we formulated High Potency Optimized Folate with 8500 mcg of 5-MTHF, saving your body the trouble.
Folic acid is the most common form of folate supplements. Once ingested, your body is supposed to convert folic acid, a synthetic version of folate, into 5-methyltetrahydrofolate, or 5-MTHF. But research shows that many people lack sufficient activity of the enzyme that's necessary to convert folic acid to 5-MTHF.1-3 A more useful approach is to take 5-MTHF directly.4-6
5-MTHF, homocysteine & cardiovascular health
Folate helps maintain healthy homocysteine levels already within the normal range. By helping to inhibit excess homocysteine, folate supports healthy levels of this important cardiovascular health biomarker.1 And 5-MTHF has been shown to be more bioavailable than folic acid in some studies.5,7
5-MTHF, homocysteine & cognitive health
5-MTHF's greater bioavailability is especially important for people who don't have enough activity of the enzyme necessary to convert folic acid to its biologically active form. Since people with elevated homocysteine levels have a greater risk of cognitive decline, the increased efficiency of 5-MTHF in supporting healthy folate status is especially crucial for aging individuals. 8,9
Take alone or with B12 for enhanced effect
The RDA for folate for non-pregnant or lactating adults is 400 mcg a day, but this high-potency formula provides 8500 mcg of this super-bioavailable form of folate. For even greater health benefits, take 5-MTHF folate with methylcobalamin (the active form of vitamin B12), vitamin B6 and/or riboflavin.
°DFE (dietary folate equivalents) Non-GMO |
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| Dosage and Use | ||||||||
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| Caution | ||||||||
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Consult your healthcare provider if you are at risk of vitamin B12 deficiency, as high-dose folate may mask signs. |
||||||||
- KEEP OUT OF REACH OF CHILDREN
- DO NOT EXCEED RECOMMENDED DOSE
- Do not purchase if outer seal is broken or damaged.
- When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.
Overview
PQQ Ovarian Harmony+ 120 capsules by CodeAge is a women’s wellness formula designed to support hormonal balance, ovarian health, cellular energy, antioxidant defense, and daily metabolic wellness. Each 4-capsule serving combines a 40:1 inositol blend with myo-inositol and D-chiro-inositol, plus 5-MTHF folate, CoQ10, PQQ, wild blueberry complex, and pomegranate extract.
This formula is especially relevant for women looking for an inositol supplement with PQQ, CoQ10, methylfolate, blueberry, and pomegranate. It also features Codeage Helix Liposomal Delivery, providing phospholipids from non-GMO sunflower lecithin to support a more advanced delivery profile. PQQ Ovarian Harmony+ is vegan, non-GMO, gluten-free, soy-free, and dairy-free.
Key Benefits
- Supports women’s hormonal balance and ovarian wellness
- Provides a 40:1 inositol blend with myo-inositol and D-chiro-inositol
- Includes 5-MTHF folate in a bioavailable methylated form
- Features CoQ10 and PQQ for cellular energy and mitochondrial support
- Includes wild blueberry complex and pomegranate extract for antioxidant support
- Uses Codeage Helix Liposomal Delivery with phospholipids from sunflower lecithin
- Vegan, non-GMO, gluten-free, soy-free, and dairy-free
Supplement Facts
Serving Size: 4 Capsules
Servings Per Container: 30
| Ingredient | Amount Per Serving | % Daily Value |
|---|---|---|
| Folate (400 mcg as L-5-Methyltetrahydrofolate from L-5-Methyltetrahydrofolic Acid, Glucosamine Salt) | 680 mcg DFE | 170% |
| 40:1 Inositol Blend | 2,050 mg | Daily Value not established |
| Myo-Inositol | 2,000 mg | Daily Value not established |
| D-Chiro-Inositol | 50 mg | Daily Value not established |
| Coenzyme Q10 | 50 mg | Daily Value not established |
| Wild Blueberry Complex (Fruit, Leaf, and Stem) (Vaccinium spp.) | 50 mg | Daily Value not established |
| Pomegranate Extract (Whole Fruit) (Punica granatum) | 25 mg | Daily Value not established |
| PQQ (Pyrroloquinoline Quinone Disodium Salt) | 10 mg | Daily Value not established |
Other Ingredients: Methylcellulose capsule, microcrystalline cellulose, Codeage Helix Liposomal Delivery providing phospholipids from non-GMO sunflower lecithin, including phosphatidylcholine.
Ingredient Breakdown
| Ingredient | Role in the Formula |
|---|---|
| 40:1 Inositol Blend | Provides myo-inositol and D-chiro-inositol in a commonly used 40:1 ratio for women’s metabolic and ovarian wellness support |
| Myo-Inositol | Primary inositol form used to support cellular signaling, metabolic balance, and ovarian health routines |
| D-Chiro-Inositol | Complements myo-inositol as part of the 40:1 inositol blend |
| 5-MTHF Folate | Bioavailable methylated folate form that supports methylation, cellular function, and women’s nutritional needs |
| Coenzyme Q10 | Supports mitochondrial function, cellular energy production, and antioxidant protection |
| PQQ | Supports mitochondrial wellness and cellular energy pathways |
| Wild Blueberry Complex | Provides polyphenol-rich plant support for antioxidant balance |
| Pomegranate Extract | Whole-fruit botanical extract included for antioxidant and phytonutrient support |
| Codeage Helix Liposomal Delivery | Provides phospholipids from non-GMO sunflower lecithin, including phosphatidylcholine |
How It Works
PQQ Ovarian Harmony+ is built around a 40:1 inositol blend, providing 2,000 mg of myo-inositol and 50 mg of D-chiro-inositol per serving. This ratio is widely recognized in women’s wellness formulas and is commonly used to support ovarian health, metabolic signaling, and hormonal balance routines.
The formula also includes 5-MTHF folate, a methylated and bioavailable form of folate that supports methylation and cellular function. This makes the product more advanced than a basic inositol-only supplement, especially for women looking for a formula that combines inositol with active folate support.
CoQ10 and PQQ add a mitochondrial and cellular energy support layer. These ingredients are commonly included in advanced wellness formulas for their role in cellular energy pathways and antioxidant defense. Together, they help position this product as a more comprehensive ovarian wellness and cellular energy support formula.
The addition of wild blueberry complex and pomegranate extract broadens the antioxidant profile with plant-based polyphenols. Codeage Helix Liposomal Delivery further enhances the formula’s premium positioning by providing phospholipids from non-GMO sunflower lecithin, including phosphatidylcholine.
Suggested Use
Adults take 4 capsules daily with 8 ounces of water or your favorite beverage, or as recommended by a healthcare practitioner. May be taken with or without food.
FAQ
What does PQQ Ovarian Harmony+ support?
It is designed to support women’s hormonal balance, ovarian wellness, cellular energy, antioxidant protection, and metabolic wellness routines.
What is the 40:1 inositol blend?
The formula provides 2,000 mg of myo-inositol and 50 mg of D-chiro-inositol per serving, creating a 40:1 ratio.
Does this formula contain methylated folate?
Yes. It includes folate as L-5-methyltetrahydrofolate, also known as 5-MTHF.
Why are CoQ10 and PQQ included?
CoQ10 and PQQ are included to support mitochondrial wellness, cellular energy pathways, and antioxidant balance.
Is this product vegan and gluten-free?
Yes. The manufacturer states that this formula is vegan, non-GMO, gluten-free, soy-free, and dairy-free.
Storage
Store in a cool, dry place. Keep out of reach of children. Do not use if the safety seal is damaged or missing.
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