Integrative Therapeutics

SUPPORTS DIGESTIVE AND IMMUNE HEALTH

Pro-Biome 50 Billion daily probiotic contains 10 diverse probiotic strains, including clinically studied strains (HN019™, HN001™, BL-04®, Bi-07®), in a delayed-release capsule to support gastrointestinal health as well as immune health.* Each serving of Pro-Biome has 50 billion live probiotic cultures plus prebiotics, a food source for good bacteria.

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SUPPORTS HEALTHY IMMUNE SYSTEM RESPONSES

This formula combines the antioxidant support of vitamin C with citrus bioflavonoids and quercetin.

DIRECTIONS

SUPPORTS IMMUNE SYSTEM FUNCTION

Calcium D-Glucarate is a form of D-glucaric acid complexed with calcium. It has been shown to support immune system function, promote estrogen metabolism and support the body's detoxification systems.

HELPS REPLENISH INTRACELLULAR GLUTATHIONE

N-Acetyl L-Cysteine (NAC) helps to replenish intracellular glutathione, which is vital in cellular antioxidant pathways.

PROMOTES HEALTHY IMMUNE SYSTEM AND HEALTHY BONES

High-potency vitamin D promotes a healthy immune system, as well as healthy bones.* Vitamin D3 125 mcg (5000 IU) provides a convenient way to increase the intake of cholecalciferol—a form of vitamin D—to promote a healthy immune system, as well as healthy bones.* Research has shown that increased intake of cholecalciferol boosts calcium absorption.

DIRECTIONS

HELPS THE BODY RELEASE ENERGY

WHAT IT IS

Riboflavin (vitamin B2) is the central component in two cofactors: flavin mononucleotide (FMN) and Flavin adenine dinucleotide (FAD). It is required for other enzyme reactions including the activation of other vitamins. Riboflavin is important for red blood cell production and helps the body in releasing energy.

HOW IT WORKS

IMPORTANT FOR RED BLOOD CELL PRODUCTION

As such, it is required for other enzyme reactions including the activation of other vitamins. Riboflavin is important for red blood cell production and helps the body in releasing energy.

DIRECTIONS

SUPPORTS THE HEALTHY BALANCE OF BACTERIA*

BERBERINE COMPLEX OFFERS TRADITIONAL GASTROINTESTINAL SUPPORT*

Berberine Complex is formulated to support the healthy balance of bacteria.*¹

HOW IT WORKS

Berberine is a constituent of some plants including Barberry (Berberis vulgaris), Oregon Grape (Berberis aquifolium), and Goldenseal (Hydrastis canadensis). Berberine Complex contains extracts of berberine-containing plants: barberry, Oregon grape, and goldenseal. In addition to berberine, Goldenseal extract also contains other alkaloids such as hydrastine. Traditional use of herbs and extracts often rely on the complex nature of plants rather than isolated bioactive compounds. Berberine Complex is intended for traditional gastrointestinal support.*

BERBERINE SUPPORTS HEALTHY BALANCE OF BACTERIA*

Goldenseal, which contains alkaloids including berberine, has been traditionally used in North American for gastrointestinal support.* Mechanistic studies in animals and cell culture models suggest berberine may modulate gut microbiota by binding to DNA of bacteria.^1-3

In animal and cell culture studies, berberine has demonstrated an ability to support the intestinal microenvironment.1 In a human Caco-2 cell model, berberine exhibited an ability to maintain tight junctions and support epithelial barrier function.⁴

REFERENCES

1. Imenshahidi M et al. Phytother Res. 2016;30:1745-64.
2. Habtemariam S. Pharmacol Res. 2020;155:104722.
3. Tian Y et al. Drug Metab Dispos. 2019;47:86-93.
4. Cao M et al. PLoS ONE. 2013;8(5):e61944.

DIRECTIONS

SUPPORTS BALANCED CORTISOL & HEALTHY STRESS RESPONSE

The ingredients in Cortisol Manager Allergen Free support healthy cortisol levels.* Cortisol is one of the most important hormones involved in the adaptation process. By supporting balanced cortisol and a healthy stress response, Cortisol Manager Allergen Free also promotes relaxation to support restful sleep.*

Cortisol Manager Allergen Free does not contain any of the top 8 most common food allergens and is ideal for patients with food sensitivities or food allergies.

THE ROLE OF CORTISOL IN TIMES OF STRESS

Cortisol is a hormone produced in the adrenal cortex that is released during times of stress. Variations in cortisol secretion can indicate how well the body is coping with stress. Cortisol homeostasis is typically characterized by peak secretion during the early morning hours with a gradual decline throughout the day. Because of its central role as a key stress hormone, cortisol is often thought of as a bridge between stress and its health impact.

WITH HERBAL INGREDIENTS

The ingredients in Cortisol Manager Allergen Free help support a balanced, adaptive cortisol response to stress.* Cortisol Manager contains a stress-reducing proprietary blend of Sensoril® brand ashwagandha (Withania somnifera) and L-theanine.*

A 2008 placebo-controlled clinical trial showed that Sensoril® ashwagandha significantly reduced serum cortisol levels and helped manage stress compared to placebo, in subjects experiencing higher levels of stress.*¹

The ingredients in Cortisol Manager Allergen Free help support relaxation, to promote restful sleep.* They also help stabilize the stress hormone cortisol to further support a healthy stress response.*

Cortisol Manager Allergen Free does not contain any of these common food allergens: milk, eggs, tree nuts, fish, shellfish, gluten, peanuts, soy, wheat, or yeast-derived ingredients.

REFERENCES

1. Auddy B et al. J Am Nutraceutical Assoc. 2008;11(1):50-6.
2. Nobre AC et al. Asia Pac J Clin Nutr. 2008;17(S1):167-68.

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