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Jarrow Formulas® Methyl B-12 & Methyl Folate plus Pyridoxal-5-Phosphate (P5P) combines the biologically active coenzyme forms of vitamin B12, B9 and B6 that support cellular energy metabolism and neurotransmitter synthesis.* This combination supports the recycling of homocysteine to methionine to support cardiovascular health.
- Provides Methyl B-12 plus Methyl Folate and Pyridoxal 5-Phosphate in a Convenient Chewable Tablet Form
- Cellular Energy Metabolism and Cardiovascular Health*
- 1000 mcg Methyl B-12 and 400 mcg Methyl Folate per serving
- Lemon and Other Natural Flavors Chewable Tablet
- Methylcobalamin (Methyl B-12) and Methyl Folate are biologically active forms of vitamin B12 and B9*
- Methyl Folate is unlike synthetic folic acid that may mask vitamin B12 deficiency*
- Pyridoxal 5-Phosphate (P-5-P) Is the Coenzyme Form of Vitamin B6*
- Vegan, Non-GMO, Gluten Free
Suggested use
Adults take 1 chewable tablet once a day or as directed by your qualified healthcare professional.
WARNING: Consult a healthcare professional before using this product if you are pregnant, nursing, under the age of 18, are taking medication (especially antiepileptic and chemotherapy) or have a medical condition; if adverse reactions occur, discontinue use.
| Supplement facts | ||
| Serving Size: 1 Tablet | ||
| Amount Per Serving | %DV | |
| Vitamin B6 (as Pyridoxal-5-Phosphate) | 1.5 mg | 88% |
| Folate (400 mcg as (6S)-5-MTHF [from (6S)-5-Methyltetrahydrofolate Glucosamine Salt]) | 680 mcg DFE‡ | 170% |
| Vitamin B12 (as Methylcobalamin) | 1,000 mcg | 41,667% |
| ‡Dietary Folate Equivalents. | ||
Other ingredients
Xylitol, microcrystalline cellulose, stearic acid (vegetable source), natural flavor, citric acid, magnesium stearate (vegetable source), silicon dioxide and rebaudioside A (stevia extract).
No wheat, gluten, soybeans, dairy, egg, fish/shellfish, peanuts/tree nuts or sesame.
Keep out of the reach of children.
P-5-P – Active Vitamin B6 for Amino Acid and Neurotransmitter Support
P-5-P provides pyridoxal 5’-phosphate (P-5-P), the active coenzyme form of vitamin B6, to support amino acid metabolism, neurotransmitter synthesis, liver function, and overall nervous system health.
This well-absorbed, bioactive form of B6 bypasses the need for conversion in the liver, making it ideal for individuals with compromised B6 metabolism.
Key Benefits*
-
Supports amino acid metabolism
-
Promotes neurotransmitter production (e.g., serotonin, dopamine, GABA)
-
Aids in liver function and red blood cell formation
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Helps maintain a healthy nervous system
-
Provides B6 in its active, ready-to-use form
Supplement Facts (per capsule)
-
Vitamin B6 (as pyridoxal 5’-phosphate): 30 mg (1765% DV)
-
Other ingredients: Microcrystalline cellulose, vegetarian capsule (hydroxypropyl methylcellulose, water), L-leucine
Suggested Use
Take 1 capsule daily with food or as directed by your healthcare professional.
Highlights
✔ Active coenzyme form of B6
✔ Hypoallergenic and well-tolerated
✔ Gluten-free, dairy-free, soy-free
✔ Suitable for vegetarians
| Serving Size 1 Capsule | ||
| Amount Per Capsule | % Daily Value | |
|---|---|---|
| Vitamin B6 ( as pyridoxal 5'- phosphate) | 30 mg | 1,765% |
Other Ingredients:
Microcrystalline cellulose, vegetarian capsule (hydroxypropyl methylcellulose, water), and L-leucine.
Suggested Use
Adults: 1 capsule daily with food or as directed by a healthcare professional. Children: As directed by a healthcare professional.
Allergy Statement
Made without common allergens: milk/casein, eggs, fish, shellfish, tree nuts, peanuts, wheat, gluten, soybeans, and sesame. Non-GMO, Vegan/ No synthetic colors, flavors, or preservatives.
Caution
Consult with your physician if you are pregnant or nursing, or have any medical condition, or taking prescription drugs, or under the age of 18 years. KEEP OUT OF REACH OF CHILDREN.
Methyl Folate ((6S)-5-methyltetrahydrofolate or (6S)-5-MTHF) is a highly biologically active form of folate.* Due to the body’s limited ability to transform synthetic folic acid into the active form of folate, supplementation with 5-MTHF is highly preferable.
- Biologically Active Folate (Methyl Folate [5-MTHF])
- Quatrefolic®: 4th Generation Development in Folate Delivery
- Increased Stability & Bioavailability
Suggested use
Adults take 1 capsule once a day with or without food or as directed by your qualified healthcare professional.
WARNING: Consult a healthcare professional before using this product if you are pregnant, nursing, under the age of 18, are taking medication (especially antiepileptic and chemotherapy) or have a medical condition; if adverse reactions occur, discontinue use.
Keep out of the reach of children.
| Supplement facts | ||
| Serving Size: 1 Capsule | ||
| Amount Per Serving | % DV | |
| Folate (1,000 mcg as (6S)-5-MTHF [from (6S)-5-Methyltetrahydrofolate Glucosamine Salt]) |
1,700 mcg DFE‡ | 425% |
| ‡Dietary Folate Equivalents. | ||
Other ingredients
Microcrystalline cellulose, capsule (hydroxypropylmethylcellulose, water) and magnesium stearate (vegetable source).
No wheat, gluten, soybeans, dairy, egg, fish/shellfish, peanuts/tree nuts or sesame.
TMG (Trimethylglycine) 750 mg 100 capsules Allergy Research Group
$26.29
Overview
TMG (Trimethylglycine) is a targeted methylation support formula designed to help maintain healthy homocysteine metabolism, liver function, and cellular resilience. Also known as betaine, TMG serves as both a methyl donor and a cellular osmolyte, supporting important metabolic and protective processes throughout the body.
This formula provides 750 mg of trimethylglycine per capsule in a simple, focused single-ingredient format for daily methylation and metabolic support.
Key Benefits
- Supports healthy methylation pathways
- Helps maintain normal homocysteine metabolism
- Supports liver and kidney cellular health
- Acts as a methyl donor for methionine production
- Functions as a cellular osmolyte for stress resilience
- Provides 750 mg of trimethylglycine per capsule
Supplement Facts
Serving Size: 1 Capsule
Servings Per Container: 100
| Ingredient | Amount Per Serving | % Daily Value |
|---|---|---|
| Trimethylglycine | 750 mg | Daily Value not established |
Other Ingredients: Hydroxypropyl methylcellulose, microcrystalline cellulose, L-leucine.
How It Works
Trimethylglycine (TMG), also known as betaine, is a methyl donor that helps convert homocysteine into methionine through methylation pathways. This supports healthy homocysteine balance and contributes to normal metabolic processes involved in cardiovascular, liver, and cellular health.
TMG also functions as a cellular osmolyte, helping cells maintain fluid balance and structural stability under stress. This dual role makes it especially useful for supporting methylation efficiency and resilience in stress-prone tissues such as the liver and kidneys.
Suggested Use
As a dietary supplement, take 1 capsule twice daily before meals, or as directed by a healthcare practitioner.
FAQ
What is TMG?
TMG stands for trimethylglycine, also known as betaine. It is a compound that supports methylation and healthy homocysteine metabolism.
What does this supplement support?
It is designed to support methylation, liver health, homocysteine metabolism, and cellular stress resilience.
How much TMG is in each capsule?
Each capsule provides 750 mg of trimethylglycine.
When should it be taken?
The suggested use is 1 capsule twice daily before meals, or as directed by a healthcare practitioner.
Is this a single-ingredient formula?
Yes. The active ingredient is trimethylglycine (TMG), making it a focused single-ingredient methylation support formula.
Storage
Store in a cool, dry place, tightly capped, away from light. Keep out of the reach of children. Use only if safety seal is intact. Variations in product color may occur.
Methyl Folate ((6S)-5-methyltetrahydrofolate or (6S)-5-MTHF) is a highly biologically active form of folate.* Due to the body’s limited ability to convert synthetic folic acid into the active form of folate, supplementation with (6S)-5-MTHF is preferable.
- A Highly Bioactive Form Of Folate
- Quatrefolic®
- Increased Stability & Bioavailability
- Extra Strength, 400mcg of Folate Per Serving
Suggested use
Adults take 1 capsule once a day with or without food or as directed by your qualified healthcare professional.
WARNING: Consult a healthcare professional before using this product if you are pregnant, nursing, under the age of 18, are taking medication (especially antiepileptic and chemotherapy) or have a medical condition; if adverse reactions occur, discontinue use.
| Supplement facts | ||
| Serving Size: 1 Capsule | ||
| Amount Per Serving | %DV | |
| Folate (400 mcg as (6S)-5-MTHF [(6S)-5-Methyltetrahydrofolate Glucosamine Salt) | 680 mcg DFE‡ | 170% |
| ‡Dietary Folate Equivalents. | ||
Other ingredients
Microcrystalline cellulose capsule (hydroxypropylmethylcellulose, water) and magnesium stearate (vegetable source).
No wheat, gluten, soybeans, dairy, egg, fish/shellfish, peanuts/tree nuts or sesame.
Keep out of the reach of children.
Jarrow Formulas® Methyl B-12 & Methyl Folate plus Pyridoxal-5-Phosphate (P-5-P) combines biologically active forms of vitamin B12, B9, and B6 that support cellular energy metabolism and neurotransmitter synthesis.* This combination supports the recycling of homocysteine to methionine to support cardiovascular health.
- Provides Methyl B-12 plus Methyl Folate and Pyridoxal 5-Phosphate in a Convenient Chewable Tablet Form
- Cellular Energy Metabolism and Cardiovascular Health*
- 5000 mcg Methyl B12 and 800 mcg Methyl Folate per serving
- Methylcobalamin (Methyl B12) and Methyl Folate are biologically active forms of vitamin B12 and B9
- Methyl Folate is unlike synthetic folic acid that may mask vitamin B12 deficiency
- Pyridoxal 5-Phosphate (P-5-P) Is the Coenzyme Form of Vitamin B6
Suggested use
Adults take 1 chewable tablet once a day or as directed by your qualified healthcare professional.
WARNING: Consult a healthcare professional before using this product if you are pregnant, nursing, under the age of 18, are taking medication (especially antiepileptic and chemotherapy) or have a medical condition; if adverse reactions occur, discontinue use.
Keep out of the reach of children.
| Supplement facts | ||
| Serving Size: 1 Tablet | ||
| Servings Per Container: 60 | ||
| Amount Per Serving | %DV | |
| Vitamin B₆ (as Pyridoxal 5-Phosphate) | 2.5 mg | 147% |
| Folate (800 mcg as 6S)-5MTHF-Methyltetrahydrofolate Glucosamine Salt) | 1,360 mcg DFE‡ | 340% |
| Vitamin B12 (as Methylcobalamin) | 5,000 mcg | 208,330% |
| ‡Dietary Folate Equivalents. | ||
Other ingredients
Xylitol, microcrystalline cellulose, stearic acid (vegetable source), natural flavor, citric acid, rebaudioside A (stevia) extract and magnesium stearate (vegetable source).
No wheat, gluten, soybeans, dairy, egg, fish/shellfish, peanuts/tree nuts or sesame.
P-5-P Plus™ with Magnesium 100 capsules SFI Health combines the active coenzyme form of vitamin B6 with magnesium in a vegetarian capsule format. The Shopify package contains 100 capsules.
Pyridoxal 5’-phosphate, also known as P-5-P, is directly utilized by the body and supports amino acid metabolism, neurotransmitter production, and metabolic reactions involving carbohydrates, fats, and proteins. Magnesium is included to assist vitamin B6 metabolism.
Key Benefits
- Supports the health and function of the brain and nervous system.
- Supports the health and function of blood vessels, skin, and eyes.
- Provides vitamin B6 in its active coenzyme form.
- Combines vitamin B6 and magnesium, which are frequently found as cofactors for the same enzymes.
Ingredient Breakdown
| Ingredient or Feature | Role in the Formula |
|---|---|
| Vitamin B6 as pyridoxal 5’-phosphate | Active coenzyme form of vitamin B6 that supports amino acid metabolism, neurotransmitter production, and other metabolic reactions. |
| Magnesium as TRAACS® magnesium bisglycinate chelate and magnesium oxide‡ | Included to assist vitamin B6 metabolism and complement vitamin B5 in enzyme cofactor functions. |
| Vegetarian capsule | Capsule made with hydroxypropyl methylcellulose and water. |
How It Works
P-5-P supplies vitamin B6 in an active coenzyme form that is directly utilized by the body. It supports metabolic processes involving amino acids, neurotransmitters, carbohydrates, fats, and proteins. Magnesium complements the formula by assisting vitamin B6 metabolism, while both nutrients are frequently found as cofactors for the same enzymes.
Suggested Use
Adults: 1 capsule daily with food or as directed by a healthcare professional. Children: As directed by a healthcare professional.
Quality & Certifications
- Non-GMO.
- Vegan.
- No synthetic colors or flavors.
- Made without common allergens: milk/casein, eggs, fish, shellfish, tree nuts, peanuts, wheat, gluten, soybeans, and sesame.
Caution
Consult your physician if you are pregnant or nursing, or have a medical condition, or are taking prescription drugs, or are under the age of 18 years. KEEP OUT OF REACH OF CHILDREN.
Frequently Asked Questions
What is P-5-P?
P-5-P is the active coenzyme form of vitamin B6, also called pyridoxal 5’-phosphate.
What does this formula contain?
It contains vitamin B6 as pyridoxal 5’-phosphate and magnesium as TRAACS® magnesium bisglycinate chelate and magnesium oxide‡.
How should adults take this product?
Adults should take 1 capsule daily with food or as directed by a healthcare professional.
Is this product vegan?
Yes. The product is identified as vegan and uses a vegetarian capsule.
What is the package size?
The Shopify package contains 100 capsules.
Overview
Biogeek Homocysteine Support Complex is a targeted methylation formula that combines bioactive forms of vitamins B2, B6, folate, and B12 with trimethylglycine (TMG) and L-serine. Each two-capsule serving is designed to support healthy homocysteine metabolism, normal methylation processes, cardiovascular health, and cognitive function.
The formula provides folate as Quatrefolic® 5-MTHF, vitamin B12 as methylcobalamin, vitamin B6 as pyridoxal-5-phosphate, and riboflavin as riboflavin-5-phosphate. These metabolically active nutrient forms work through complementary remethylation and transsulfuration pathways. The 60-capsule bottle provides 30 daily servings.
Key Benefits
- Supports healthy homocysteine metabolism
- Promotes normal methylation processes
- Supports cardiovascular and circulatory health
- Helps maintain normal brain and cognitive function
- Provides bioactive forms of vitamins B2, B6, folate, and B12
- Includes 900 mg of trimethylglycine per serving for additional methyl-donor support
- Provides a convenient 30-day supply
Supplement Facts
Serving Size: 2 capsules
Servings Per Container: 30
| Ingredient | Amount Per Serving | % Daily Value |
|---|---|---|
| Riboflavin (as Riboflavin-5-Phosphate) | 30 mg | 2308% |
| Vitamin B6 (as Pyridoxal-5-Phosphate) | 10 mg | 588% |
| Folate (as Quatrefolic® [6S]-5-methyltetrahydrofolate, glucosamine salt) | 3400 mcg DFE | 850% |
| Vitamin B12 (as Methylcobalamin) | 1000 mcg | 41667% |
| Trimethylglycine (TMG) | 900 mg | * |
| L-Serine | 100 mg | * |
* Daily Value not established.
Other Ingredients
Cellulose (capsule), microcrystalline cellulose, ascorbyl palmitate, dicalcium phosphate, silicon dioxide.
Ingredient Breakdown
| Ingredient | Role in the Formula |
|---|---|
| Riboflavin-5-Phosphate | A bioactive form of vitamin B2 that supports enzymes involved in cellular energy production, vitamin metabolism, and normal homocysteine conversion. |
| Pyridoxal-5-Phosphate | The metabolically active form of vitamin B6. It supports the transsulfuration pathway through which homocysteine is converted into other useful compounds. |
| Quatrefolic® 5-MTHF | A biologically active form of folate that participates directly in methylation and supports the conversion of homocysteine back into methionine. |
| Methylcobalamin | An active form of vitamin B12 that works with 5-MTHF in the remethylation pathway. It also supports normal neurological function and red blood cell formation. |
| Trimethylglycine (TMG) | Also known as betaine, TMG serves as a methyl donor and supports an additional pathway for converting homocysteine into methionine. |
| L-Serine | An amino acid involved in one-carbon metabolism and the production of compounds needed for normal cellular, neurological, and methylation processes. |
How It Works
Homocysteine is an amino acid produced during the normal metabolism of methionine. The body continually converts homocysteine back into methionine or directs it through the transsulfuration pathway. These processes depend on adequate availability of specific B vitamins, methyl donors, and related nutrients.
Quatrefolic® 5-MTHF and methylcobalamin work together in the primary remethylation pathway, while TMG provides an additional source of methyl groups through a complementary pathway. Riboflavin-5-phosphate supports enzymes involved in folate metabolism, and pyridoxal-5-phosphate supports the conversion of homocysteine through the transsulfuration pathway.
By supplying these nutrients together, Biogeek Homocysteine Support Complex provides comprehensive nutritional support for normal methylation, healthy homocysteine metabolism, cardiovascular function, and neurological health.
Who Is It For?
- Adults seeking targeted nutritional support for healthy homocysteine metabolism
- People who want to support normal methylation processes
- Those seeking cardiovascular and circulatory health support
- Adults interested in maintaining healthy cognitive and neurological function
- People looking for bioactive forms of folate, vitamin B12, vitamin B6, and riboflavin
- Those advised by a qualified healthcare practitioner to supplement methylation-related nutrients
Suggested Use
Take two capsules daily with meals, or use as directed by a qualified healthcare practitioner.
Caution
Consult a qualified healthcare professional before use if you are pregnant or nursing, take prescription medication, have a medical condition, or are being monitored for homocysteine, folate, or vitamin B12 status. Keep out of reach of children. Use only as directed.
Frequently Asked Questions
What is Biogeek Homocysteine Support Complex designed to support?
The formula is designed to support healthy homocysteine metabolism, normal methylation, cardiovascular health, and cognitive function.
How many capsules are in one serving?
One serving is two capsules. The bottle contains 60 capsules, providing 30 daily servings when used as directed.
What forms of B vitamins are included?
The formula provides vitamin B2 as riboflavin-5-phosphate, vitamin B6 as pyridoxal-5-phosphate, folate as Quatrefolic® 5-MTHF, and vitamin B12 as methylcobalamin.
What is Quatrefolic®?
Quatrefolic® is a branded form of [6S]-5-methyltetrahydrofolate, commonly called 5-MTHF. It is a biologically active form of folate that can participate directly in folate-dependent methylation processes.
Why does the formula contain TMG?
Trimethylglycine, or TMG, functions as a methyl donor. It supports a complementary pathway used by the body to convert homocysteine into methionine.
Is this a complete B-complex supplement?
No. This is a targeted formula containing selected B vitamins and methylation-support nutrients rather than all eight essential B vitamins found in a complete B-complex.
Can this formula be taken every day?
It is formulated for daily use at two capsules per day. Because it provides concentrated amounts of folate and vitamin B12, consult a qualified healthcare practitioner if you have questions about long-term use or combining it with other B-vitamin supplements.
Can supplements replace homocysteine testing?
No. A supplement cannot determine your homocysteine status. A qualified healthcare professional can order appropriate laboratory testing and help interpret the results when monitoring is needed.
Storage
Store tightly closed in a cool, dry place away from direct sunlight, heat, and moisture.
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