About Microbiome Labs
Microbiome Labs is a professional supplement brand focused on microbiome optimization, spore-based probiotics, and evidence-based gut health solutions.
The brand pioneered the first 100% spore-based, multi-strain probiotic in 2013 and continues to develop products for gastrointestinal health, immune support, metabolic wellness, skin health, and whole-body microbiome balance.
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Overview
Omega Ultra SPM™ 60 Softgels by Microbiome Labs is a gut-specific, full-spectrum fish oil formula designed to support healthy gut microbiome balance, gut barrier integrity, immune function, mucosal lining health, brain function, and overall omega-3 status. Product materials also present this formula as MegaMarine™, a comprehensive fish oil with EPA, DHA, DPA, and specialized pro-resolving mediators.
Unlike many fish oil supplements that are positioned mainly for brain or general cardiovascular support, Omega Ultra SPM™ is formulated with a higher EPA content than DHA to support digestive and intestinal health. Each 2-softgel serving provides 1,500 mg of total omega-3 fatty acids, including 850 mg EPA, 450 mg DHA, 100 mg DPA, and 200 mg total PRMs, including 18-HEPE, 17-HDHA, and 14-HDHA.
The omega-3s are provided in triglyceride form, a form used to support absorption and bioavailability. The formula also includes naturally occurring omega-3 derivatives called specialized pro-resolving mediators, which are included to support healthy immune function, gut barrier function, and mucosal lining support.
Key Benefits
- Comprehensive full-spectrum fish oil formula
- Designed specifically to support gut and intestinal health
- Supports a healthy gut microbiome
- Supports healthy gut barrier function
- Supports healthy intestinal mucosa and mucosal lining
- Supports healthy immune system function
- Supports healthy brain function
- Provides triglyceride-form omega-3s for absorption and bioavailability
- Formulated with higher EPA content than DHA to support gut health
- Includes DPA, often called the “forgotten fatty acid”
- Includes specialized pro-resolving mediators for immune resolution support
- Supports EPA and DHA tissue status and bioavailability
- Supports intestinal alkaline phosphatase activity and gut microbial balance
- Clean, shelf-stable fish oil softgel
- FOS-certified for dolphin-safe and sustainable fishing practices
- Natural lemon flavor
- Suitable for ages 8 and older when used as directed
Supplement Facts
Serving Size: 2 Softgels
Servings Per Container: 30
| Ingredient | Amount Per Serving | % Daily Value |
|---|---|---|
| Calories | 25 | |
| Total Fat | 2.5 g | 3% |
| Cholesterol | 10 mg | 3% |
| Protein | <1 g | |
| Total Omega-3 Fatty Acids | 1,500 mg | Daily Value not established |
| EPA, Eicosapentaenoic Acid | 850 mg | Daily Value not established |
| DHA, Docosahexaenoic Acid | 450 mg | Daily Value not established |
| DPA, Docosapentaenoic Acid | 100 mg | Daily Value not established |
| Total PRMs, including 18-HEPE, 17-HDHA, and 14-HDHA | 200 mg | Daily Value not established |
Ingredients: Highly refined and concentrated omega-3 marine oil from one or more of the following: anchovy, squid, sardine, herring, and mackerel; natural lemon flavor; natural mixed tocopherols; capsule shell made with bovine gelatin, glycerin, and purified water.
Contains Fish: Anchovy, sardine, herring, and mackerel.
Capsule Note: Contains bovine gelatin and is not a vegetarian or vegan softgel.
Ingredient Breakdown
| Ingredient or Feature | Role in the Formula |
|---|---|
| Total Omega-3 Fatty Acids | Provides a full-spectrum omega-3 profile designed to support gut, immune, brain, cellular, and overall wellness. |
| EPA, Eicosapentaenoic Acid | Primary omega-3 in this formula. EPA is emphasized for gut health support, intestinal mucosa support, and healthy immune signaling. |
| DHA, Docosahexaenoic Acid | Omega-3 fatty acid best known for supporting brain function and cell membrane health, while also supporting gastrointestinal nerve cell function and signal conduction. |
| DPA, Docosapentaenoic Acid | Often called the “forgotten fatty acid.” DPA supports EPA and DHA tissue status, helps maintain a healthy gut, and may support the bioavailability of EPA and DHA. |
| Total PRMs | Specialized pro-resolving mediators and omega-3 derivatives included to support healthy immune resolution pathways and gut barrier function. |
| 18-HEPE | Omega-3-derived mediator associated with pro-resolving pathways and healthy immune function. |
| 17-HDHA and 14-HDHA | DHA-derived mediators included as part of the PRM complex to support healthy resolution and immune balance. |
| Triglyceride-Form Fish Oil | Omega-3s in triglyceride form are used to support absorption and bioavailability. |
| Highly Refined Marine Oil | Concentrated fish oil source providing EPA, DHA, DPA, and PRMs from marine ingredients. |
| Natural Lemon Flavor | Helps create a cleaner sensory profile for a fish oil softgel. |
| Natural Mixed Tocopherols | Included to help protect the oil and support formula stability. |
| FOS Certification | Friends of the Sea certification supports dolphin-safe and sustainable fishing practices. |
How It Works
Omega Ultra SPM™ is formulated around a gut-specific omega-3 strategy. Fish oil is widely used for whole-body wellness, but this formula is designed with a ratio and ingredient profile intended to support digestive and intestinal health, not only general omega-3 intake.
The formula provides higher EPA content than DHA. EPA is an omega-3 fatty acid associated with healthy immune signaling and support for intestinal mucosa. The product materials describe EPA as especially relevant for gut health and healthy mucosal support.
DHA supports brain function and is also important for phospholipid membranes. It helps maintain phosphatidylserine levels, which are important for cell membrane structure and function. DHA also supports healthy brain and gastrointestinal tract nerve cell function and signal conduction.
DPA is included because it may help support EPA and DHA tissue status and bioavailability. It is often overlooked in standard fish oil formulas, but Microbiome Labs highlights DPA as a key part of a full-spectrum omega-3 profile for gut and immune support.
The formula also includes specialized pro-resolving mediators, or SPM-related compounds. These omega-3 derivatives support healthy immune resolution pathways. While the body can convert omega-3 fatty acids into specialized pro-resolving mediators, this process can be influenced by stress, genetics, diet, and lifestyle factors. Omega Ultra SPM™ accounts for this by including PRMs directly in the formula.
This makes Omega Ultra SPM™ a practical option for adults and children ages 8+ looking for a gut-specific fish oil, EPA-rich omega-3 supplement, triglyceride-form fish oil, omega-3 with DPA, fish oil with specialized pro-resolving mediators, gut barrier support supplement, or Microbiome Labs fish oil formula.
Gut Microbiome Support
Omega Ultra SPM™ is positioned as a fish oil formula for gut support. Product materials note that omega-3 supplementation has been associated with support for microbial diversity, including beneficial organisms such as Bifidobacterium, Akkermansia muciniphila, and Lactobacillus.
The formula is also described as supporting intestinal alkaline phosphatase activity. Intestinal alkaline phosphatase is involved in maintaining a balanced gut environment and supporting healthy detoxification of lipopolysaccharide within the gut lumen. By supporting gut barrier function and mucosal lining health, Omega Ultra SPM™ helps support the digestive and immune systems together.
EPA, DHA, DPA, and SPMs
EPA is the dominant omega-3 in Omega Ultra SPM™. This higher-EPA formulation is designed to support gut health, healthy intestinal mucosa, immune balance, and normal inflammatory response pathways.
DHA is included to support healthy brain function, cellular membranes, phospholipid balance, and nervous system signaling. DHA is often associated with brain health, but it also contributes to gastrointestinal nerve cell function.
DPA helps round out the full-spectrum omega-3 profile. It supports EPA and DHA tissue status and contributes to gut and cellular wellness. DPA may also support healthier cells and tissues by supporting normal COX pathway balance.
Specialized Pro-Resolving Mediators are omega-3 derivatives involved in resolution pathways. They help support specific immune functions and may be especially relevant when the body’s own SPM production is affected by stress, genetics, diet, or lifestyle factors.
Who Is It For?
Omega Ultra SPM™ may be suitable for adults and children ages 8 and older who want targeted support for gut health, gut barrier integrity, mucosal lining health, immune balance, brain function, and full-spectrum omega-3 intake. It may be especially useful for people seeking a practitioner-quality fish oil formulated specifically for digestive and intestinal support.
This product may also fit individuals looking for a clean, shelf-stable fish oil softgel with EPA, DHA, DPA, and specialized pro-resolving mediators in one formula.
Suggested Use
Ages 8+: Take 2 softgel capsules daily with a meal, or as directed by your healthcare practitioner.
Caution
Consult a healthcare professional before use if you are pregnant, nursing, taking medication, have a medical condition, have a seafood or fish allergy, are taking anticoagulant or antiplatelet medication, or are planning a medical procedure. Keep out of reach of children.
This product contains fish and bovine gelatin. Individuals with fish allergies, gelatin restrictions, or specific dietary preferences should review the label carefully before use.
Quality & Features
- Gut-specific fish oil formula
- Full-spectrum omega-3 profile
- 1,500 mg total omega-3 fatty acids per serving
- 850 mg EPA per serving
- 450 mg DHA per serving
- 100 mg DPA per serving
- 200 mg total PRMs per serving
- Includes 18-HEPE, 17-HDHA, and 14-HDHA
- Triglyceride-form fish oil
- Higher EPA content than DHA for gut-focused support
- Clean, shelf-stable softgel format
- Natural lemon flavor
- FOS-certified for dolphin-safe and sustainable fishing practices
- TrustScore™ Verified by SuppCo with an 8.69 “Very good” score
- Manufacturing standards rated high by SuppCo
- Testing benchmarks rated high by SuppCo
- Product quality rated high by SuppCo
- 60 softgels per bottle
- 30 servings per container
Frequently Asked Questions
What is Omega Ultra SPM™?
Omega Ultra SPM™ by Microbiome Labs is a gut-specific fish oil supplement formulated with EPA, DHA, DPA, and specialized pro-resolving mediators to support gut, immune, brain, and cellular health.
Is Omega Ultra SPM™ the same as MegaMarine™?
Product materials present the formula as MegaMarine™, a gut-specific fish oil. Omega Ultra SPM™ uses the same positioning: a full-spectrum omega-3 formula designed to support a healthy gut microbiome, gut barrier function, immune function, and mucosal lining health.
How much omega-3 is in each serving?
Each 2-softgel serving provides 1,500 mg of total omega-3 fatty acids.
How much EPA is in each serving?
Each serving provides 850 mg of EPA, eicosapentaenoic acid.
How much DHA is in each serving?
Each serving provides 450 mg of DHA, docosahexaenoic acid.
How much DPA is in each serving?
Each serving provides 100 mg of DPA, docosapentaenoic acid.
What are PRMs?
PRMs are pro-resolving mediators and related omega-3 derivatives. This formula provides 200 mg total PRMs, including 18-HEPE, 17-HDHA, and 14-HDHA.
Why does this formula contain more EPA than DHA?
Omega Ultra SPM™ is formulated with higher EPA content because the product is designed specifically for gut health, intestinal mucosa support, gut barrier support, and immune function.
What is DPA?
DPA, or docosapentaenoic acid, is an omega-3 fatty acid often called the “forgotten fatty acid.” It supports EPA and DHA tissue status and helps maintain a healthy gut.
What does triglyceride-form fish oil mean?
Triglyceride-form fish oil refers to the form of omega-3s used in the softgels. This form is included to support absorption and bioavailability.
How does Omega Ultra SPM™ support the gut microbiome?
The formula is designed to support a healthy gut microbiome and healthy microbial diversity, including support for beneficial organisms such as Bifidobacterium, Akkermansia muciniphila, and Lactobacillus.
Does Omega Ultra SPM™ support gut barrier function?
Yes. Omega Ultra SPM™ is formulated to support healthy gut barrier function and mucosal lining health.
Does this product support immune function?
Yes. The omega-3 fatty acids and specialized pro-resolving mediators in the formula are included to support healthy immune function and immune balance.
Does this product support brain function?
Yes. DHA and the full-spectrum omega-3 profile support healthy brain function and cell membrane health.
How many softgels are in one bottle?
Each bottle contains 60 softgels.
How many servings are in one bottle?
Each bottle provides 30 servings based on a 2-softgel serving size.
How should I take Omega Ultra SPM™?
Ages 8 and older take 2 softgels daily with a meal, or as directed by a healthcare practitioner.
Does Omega Ultra SPM™ contain fish?
Yes. The product contains fish, including anchovy, sardine, herring, and mackerel. The marine oil may also be sourced from one or more of anchovy, squid, sardine, herring, and mackerel.
Is Omega Ultra SPM™ vegan?
No. This product contains fish oil and a bovine gelatin softgel capsule.
Is the fish oil flavored?
Yes. The formula includes natural lemon flavor.
Is Omega Ultra SPM™ shelf-stable?
Yes. Product materials describe it as a clean, shelf-stable fish oil.
What does FOS-certified mean?
FOS refers to Friends of the Sea certification, which supports dolphin-safe and sustainable fishing practices.
Who should consult a healthcare professional before use?
Consult a healthcare professional before use if you are pregnant, nursing, taking medication, have a medical condition, have a fish or seafood allergy, use blood-thinning medication, or are considering use for a child.
Storage
Store in a cool, dry place away from heat, light, and moisture. Keep the bottle tightly closed and out of reach of children. Do not use if the safety seal is damaged or missing.
EpicDefense – Next-Gen Immunobiotic Immune Support
EpicDefense is a science-backed, next-generation immunobiotic formula designed to provide daily and seasonal immune support year-round. It leverages clinically studied immunobiotics (LGG®, BB-12®, EpiCor®) and chelated zinc bisglycinate to help regulate immune balance, optimize mucosal immune function, and support respiratory and nasal comfort.
Key Benefits
- Fortifies immune function with consistent daily support.**
- Delivers year-round, gut-powered immunity via immunobiotics.**
- Regulates healthy immune balance and signaling molecules.**
- Supports respiratory wellness and nasal airflow comfort.**
- Optimizes mucosal immune function and seasonal resilience.**
- Promotes balanced inflammatory responses.**
Supplement Facts
Serving Size: 1 Capsule
Servings Per Container: 30
| Amount Per Serving | mg / CFU | % Daily Value |
|---|---|---|
| Zinc (as Zinc Bisglycinate Chelate) [Albion®] | 10 mg | 91% |
| Dried Yeast Fermentate (EpiCor®) (Saccharomyces cerevisiae) | 500 mg | † |
| Proprietary Probiotic Blend – Total Probiotic Cultures Lactobacillus rhamnosus (LGG®); Bifidobacterium lactis (BB-12®) |
14 mg (2 Billion CFU) | † |
† Daily Value not established.
Other Ingredients: Hypromellose (capsule), microcrystalline cellulose, magnesium stearate, silica.
Suggested Use
Take 1 capsule per day or as directed by your healthcare practitioner.
Allergy Statement
Gluten-free. Free from 9 major allergens. No artificial colorings or flavorings.
What Are Immunobiotics?
Immunobiotics are specific probiotics, postbiotics, or microbial components that promote immune health by activating gut-microbiome–induced immunity. They help balance the microbiota, boost immune cell activity, support antibody production, and strengthen the gut barrier—key for whole-body immune resilience.
FAQ
Take 1 capsule daily, with or without food, or as advised by your healthcare professional. Regular probiotics primarily support digestive balance. Immunobiotics also directly modulate immune responses in the gut, promoting antibody production and mucosal immunity for daily and seasonal support. The formula is free from 9 major allergens and contains no artificial colors or flavors. Generally considered safe; however, always consult your healthcare provider before starting any new supplement. Tested for potency, purity, and safety; solvent-free production; soy-free, dairy-free, non-GMO.How do I take EpicDefense?
How is this different from regular probiotics?
Does EpicDefense contain allergens?
Is it safe during pregnancy or breastfeeding?
Quality standards
Caution
- If you are pregnant, nursing, taking medication, or have a medical condition, consult a healthcare professional before use.
- Keep out of reach of children.
- Do not use if safety seal is broken or missing.
- Store in a cool, dry place.
**These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Total Gut Restoration Kit 2 (Powder) from Microbiome Labs is an advanced protocol designed to support gut health. The formula combines MegaSporeBiotic™, MegaPre™, and MegaMucosa™ to support a balanced microbial ecosystem, a healthy gut barrier, and balanced immune and digestive function.
MegaSporeBiotic™ is a spore-based, broad-spectrum probiotic that supports microbial diversity and healthy gut barrier function. MegaPre™ is a precision prebiotic powder that supports beneficial bacteria and microbial diversity, while MegaMucosa™ provides mucosal support and includes a flavobiotic to support microbial diversity and short-chain fatty acid production. MegaPre™ has a Pineapple Orange Guava flavor, and MegaMucosa™ has a Berry Açaí flavor.
Key Benefits
- Supports a healthy and harmonious microbial ecosystem
- Helps maintain healthy gut barrier function
- Supports microbial diversity and beneficial bacterial communities
- Supports balanced immune and digestive function
- Provides mucosal support through MegaMucosa™
- Supports short-chain fatty acid production
Supplement Facts
Servings Per Container: MEGA SporeBiotic: 90; MEGAPRE Precision Prebiotic: 30; MEGA MUCOSA: 30
| Ingredient | Amount Per Serving | % Daily Value |
|---|---|---|
| Total Carbohydrate | 5 g | 2% |
| Dietary Fiber | 1 g | 4% |
| Proprietary Functional Fiber Blend | 4 g | † |
| Protein | 1 g | 2% |
| L-Proline | 1 g | † |
| L-Serine | 700 mg | † |
| L-Threonine | 600 mg | † |
| L-Cysteine | 80 mg | † |
| Serum-derived immunoglobulin concentrate (ImmunoLin®) | 1 g | † |
| Immunoglobulin G (IgG) | 506 mg | † |
| Immunoglobulin M (IgM) | 46 mg | † |
| Immunoglobulin A (IgA) | 9 mg | † |
| Bovine Serum Albumin | 50 mg | † |
| Citrus bioflavonoids (MicrobiomeX®) | 500 mg | † |
† Daily value not established. Percent Daily Values are based on a 2,000 calorie diet.
Other Ingredients: MEGA SporeBiotic: Cellulose, vegetable capsule (cellulose and water). MEGAPRE: Natural pineapple orange guava flavors, citric acid, stevia, silicon dioxide, rebaudioside M. MEGA MUCOSA: Natural berry acai flavors, citric acid, malic acid, sunflower lecithin, stevia, rebaudioside M.
Ingredient Breakdown
| Ingredient or Feature | Role in the Formula |
|---|---|
| MegaSporeBiotic™ | Spore-based, broad-spectrum probiotic designed to support microbial diversity and healthy gut barrier function. |
| MegaPre™ | Precision prebiotic made with non-digestible oligosaccharides to support beneficial bacteria and microbial diversity. |
| MegaMucosa™ | Mucosal support formula designed to support a healthy mucosal barrier, microbial diversity, and short-chain fatty acid production. |
| Proprietary Functional Fiber Blend | Provides functional fiber support within the formula. |
| Serum-derived immunoglobulin concentrate (ImmunoLin®) | Included as part of the MegaMucosa™ formula for mucosal and immune support. |
| Citrus bioflavonoids (MicrobiomeX®) | Included as the flavobiotic component of the formula. |
How It Works
The kit combines probiotic, prebiotic, and mucosal-support components. MegaSporeBiotic™ supports the microbial ecosystem and gut barrier, MegaPre™ helps reinforce beneficial microbial changes by supporting selected beneficial bacteria, and MegaMucosa™ supports the mucosal barrier while contributing to microbial diversity and short-chain fatty acid production.
Suggested Use
MegaSporeBiotic™
- Week 1: Take 1 capsule every other day.
- Week 2: Take 1 capsule daily.
- Weeks 3-4+: Take 2 capsules daily.
Take with a meal.
MegaPre™ Powder
In addition to MegaSporeBiotic™:
- Week 5: Add 1/2 scoop to 16 oz water daily.
- Weeks 6-8+: Add 1 scoop to 16 oz water daily.
Take with or without a meal.
MegaMucosa™ Powder
In addition to MegaSporeBiotic™ and MegaPre™:
- Week 9: Add 1/2 scoop to 16 oz water daily.
- Weeks 10-12+: Add 1 scoop to 16 oz water daily.
Caution
MegaMucosa™ is bovine-based. Do not consume if you have a beef allergy.
Frequently Asked Questions
What is Total Gut Restoration?
Total Gut Restoration is a protocol combining MegaSporeBiotic™, MegaPre™, and MegaMucosa™ to support gut health, microbial balance, gut barrier function, and balanced immune and digestive function.
What supplements are included in the formula?
The formula includes MegaSporeBiotic™, MegaPre™ powder, and MegaMucosa™ powder.
What flavor is MegaPre™?
MegaPre™ has a Pineapple Orange Guava flavor.
What flavor is MegaMucosa™?
MegaMucosa™ has a Berry Açaí flavor.
How should MegaSporeBiotic™ be taken?
Follow the staged directions and take it with a meal.
How should the powder products be taken?
MegaPre™ and MegaMucosa™ are added to water according to the staged directions. MegaPre™ may be taken with or without a meal.
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