About nuBioAge
nuBioAge is a longevity science and wellness network created for medical practitioners and allied health professionals focused on evidence-based longevity medicine.
The brand supports provider education, clinical tools, and practitioner-guided protocols designed around healthy aging, vitality, metabolic wellness, and personalized longevity care.
14 products
Sort by:
14 products
The Amino Drink
iCell Water™ (The Amino Drink) Packets optimizes cell signaling through modulation of cell volume. Using neutral amino acid osmolytes and creatine to maximize cellular hydration. Revolutionizing the way we drink water.
Ingredients
- L-Alanine: 5g
- Creatine Monohydrate: 5g
- Glycine: 4g
- L-Glutamine: 3g
- L-Leucine: 3g
Recommended Use
Use 1 scoop in a minimum of 64 ounces of water. Drink throughout the day.
Enhanced Cell Volume
- Places cell in the ultimate state of signaling capacity
- Promotes lypolysis and counteracts proteolysis and glycogenolysis.
- Prevents intracellular catabolic effect.
- Higher intracellular water showed better functional performance independent of muscle mass
- Intracellular water was the main predictor of leg strength and jump performance in highly trained athletes.
- Decrease in ICW during training was found to have reduced power and grip strength.
Butyrate prodrug, tributyrin, is proven to overcome the pharmacokinetic drawbacks of butyrate supplementation. Butyrate can epigenetically regulate gene expression. nuButyrate has the only regulatory compliant tributyrin on the market clinically substantiated to be bioavailable in the colon and to show improvement in boosting butyrate-producing bacteria. Butyrate has been shown to neutralize reactive oxygen species by the overexpression of glutathione peroxidase, causing the inhibition of NF-kB, leading to the activation of antioxidant enzymes and impairing inflammatory genes. nuButyrate is crucial to immune, gut, and metabolic health.
Ingredients
• Tributyrin (as CoreBiome®): 500 mg
Recommended Use
Take 2 capsules daily.
Helping support digestive and gastrointestinal health
through impacting gene expression, Tributyrin is the only
form to be clinically substantiated bioavailability in the
colon. It supports immune health by supporting tight
junctures in the intestinal lining normalizing inflammatory
responses in the gastrointestinal tract.
Butyrate prodrug Tributyrin is proven to
overcome the pharmacokinetic drawbacks of
butyrate supplementation while eliminating
bad smell and taste.
Cellular Pathways
The overexpression of GPx causes the blocking of the
NF-kB cascade, resulting in the attenuation of the
inflammatory response by impairing the expression of
NF-kB inflammatory genes.
Butyrate induces maturation and expansion of colonic
regulatory T cells
PPARy, strongly expressed in the colon, controls the energy
production required for microbiome homeostasis through
fatty acid oxidation.
Why this matters:
3 days of Abx administered by oral gavage resulted in an
early complete loss of bacterial groups. Despite outgrowth of
several resistant organisms, cecal contents from abx-treated
mice lost the ability to produce SCFAs from inulin and lost HIF
expression, both of which are restored by butyrate administration.
Butyrate is a potent activator of AMPK in colonic cell lines.
*Kelly, C. Crosstalk between Microbiota-Derived Short-Chain Fatty Acids and Intestinal Epithelial
HIF Augments Tissue BarrierFunction. Cell Host Microbe. 2015; 17(5): 662–671
Clinical Studies
nuButyrate™ Results
Butyrate prodrug Tributyrin is proven to overcome the pharmacokentic drawbacks of butyrate supplementation while eliminating bad smell and taste. It has been clinically substantiated bioavailability in the colon.
* who performed the study?
• Faecalibacterium prausnitzii increased 41% over placebo
• Anaerostipes increased 67% over placebo
• Both bacteria are butyrate producers and their benefits are associated with butyrate production (healthy microbiome, immunity, healthy inflammatory response, etc.)
Tributyrin (as CoreBiome®)
• Is the #1 selling SCFA on the market
• Has clinically substantiated bioavailability in the colon
• In a 48-hour study using a gastrointestinal model [and that was repeated in a four-week study], CoreBiome® limited IL6, TNF-alpha and measurements of epithelial function through TEER (transepithelial electrical resistance), suggesting that it may support gut barrier function
• Is the ONLY SCFA with marketable claims
Synergy with Larazotide, Guttides (BPC-157 + KPV):
Critical component of GI protocols including Guttides (BPC-157 + KPV), Larazotide and low dose pentosan polysulfate.
Larazotide + nuButyrate™
Larazotide protects the gut by improving and repairing tight junctions providing gut permeability protection. Larazotide improves the structure and integrity of the gut while nubutyrate works on creating the optimal environment through immune and inflammation modulation.
Guttides + nuButyrate™
The combination of gut health peptides BPC-157 and KPV improve inflammation and mucosal barrier integrity. nuButyrate is commonly used in conjunction to further improve the GI inflammatory state.
Description
Collagen is a critical component of many different aspects of the human body. Almost 30% of the total body’s protein consists of collagen. There are 2 mechanisms that the body utilizes collagen via stimulating cell metabolism and increasing specific amino acids for collagen synthesis.
Collagen Benefits
- Mobile joints
- Less joint pain
- Smoother skin
- Hair and nail health
- Stronger ligaments and tendons
- Healthy muscle
Ingredients
- FORTIGEL®: 5g
- Protein: 15g
- Vitamin C: 90mg
- Iron: 0.37mg
- Sodium: 135mg
Recommended Use
Combine 1 scoop with 8 fl oz of liquid. Mix thoroughly.
aimed at joint cartilage regeneration, backed by clinical
evidence for reducing pain, enhancing mobility, and
promoting long-term cartilage health safely.
Collagen’s significance extends to skin
elasticity and hydration; supplements
can potentially enhance skin moisture,
elasticity, and reduce wrinkles for a more
youthful appearance.
A positive effect of collagen peptides on the regeneration of
hyaline cartilage was observed in cultured chondrocytes.
The stimulation of the extracellular matrix (ECM) synthesis
is probably caused by specific Hyp-Pro-Gly containing
peptides with a molecular size <10 kD.
As individuals age, collagen levels decrease, leading to less flexible and more brittle cartilage. Aging-related changes increase collagen cross-linking, stiffening cartilage and making it prone to fatigue failure. Structural collagen changes, including degradation, are associated with skin wrinkling, bone deterioration, and cardiovascular and respiratory issues. Cartilage degeneration, a result of aging, can lead to arthritis, also known as degenerative joint disease.
Clinical Studies
Improvement of activity-related knee joint discomfort following supplementation
of specific collagen peptides.
• After 12 weeks 40% of patients reported no knee pain and 70%achieved a positive effect of therapy
Hydrolyzed Collagen is a key component in proteoglycans and collagen type II formation which can help repair cartilage degradation and decrease joint pain, typically used in joint and inflammatory pain protocols.
Collagen supplementation when broken down can form foundational building blocks for muscle and ligament repair. Sermorelin improves growth hormone secretion while BPC-157 has been shown to upregulate growth hormone receptors. These have been used in synergy to improve injury and recovery.
Collagen supplementation helps rejuvenate collagen type III in the skin which is important for skin elasticity and overall skin health. GHK-Cu has been shown to enhance skin elasticity.
Dihydrohonokiol (DHH-B) is a natural compound
extracted from magnolia bark, known for its anxiolytic
effects. It promotes a sense of calm without causing
motor dysfunction, amnesia, or physical dependence.
Unlike synthetic drugs, DHH-B doesn’t exacerbate side
effects or lead to withdrawal symptoms.
As a potent form of honokiol, it offers a
natural alternative for anxiety and stress
management.
Cellular Pathways
Chronic administration of honokiol, a natural
compound, results in the buildup of a metabolite called
dihydrohonokiol-B (DHH-B), which is responsible for
honokiol’s anxiolytic (anxiety-reducing) effects. DHH-B
acts as a potent agent to reduce anxiety by targeting
the GABA_A receptor-gated chloride channel complex
in the brain, suggesting a specific mechanism through
which DHH-B can alleviate anxiety.
Why this matters:
Magnolia bark and its extracts need to be administered repeatedly to achieve their effects, whereas DHH-B (dihydrohonokiol-B) provides immediate anxiety-reducing benefits. Unlike benzodiazepines, a common class of anxiolytics, DHH-B does not lead to motor dysfunction or dependency. This underlines DHH-B’s promise as a therapeutic option for anxiety disorders, showcasing its capacity to alter neurotransmitter systems for effective anxiolytic outcomes without the significant side effects associated with many traditional medications.
Clinical Studies
Honokiol, a putative anxiolytic agent extracted from magnolia bark,
has no diazepam-like side-effects in mice
• Anxiety reducing effects without affecting motor activity or muscle tone
• Honokiol did not exhibit withdrawal symptoms seen with benzodiazepines
• Honokiol did not disrupt learning, memory or central nervous system depression at anxiolytic doses
Synergy with Oxytocin, Sermorelin, GLP-1:
DHH-B + Oxytocin
Oxytocin has been shown to decrease stress by its ability to reduce cortisol while DHH-B also has an anxiolytic effect by stimulating gaba receptors and manage stress and anxiety.
DHH-B + Sermorelin
DHH-B helps patients manage sleep patterns. Typcially used with Sermorelin which improves night time growth hormone secretion that has been shown to enhance deep sleep.
DHH-B + GLP-1
Cortisol has been shown to be anabolic to fat tissue and catabolic to muscle tissue putting effective weight loss on hold. The combination of GLP-1 with DHH-B has been used to mitigate stress induced weight loss resistance.
Ingredients
• Dihydrohonokiol-B (DHH-B) (Magnolia Bark): 15mg
Recommended Use
Take 1 capsule daily.
AKG+ (Calcium Alpha-Ketoglutarate) An intermediate molecule in the Krebs cycle which determines the overall rate of the citric acid cycle of the organism. AKG as a precursor of glutamate and glutamine is a central metabolic fuel for cells of the gastrointestinal tract as well. AKG can decrease protein catabolism and increase protein synthesis to enhance bone tissue formation in the skeletal muscles.
Ideal AKG dose is 3 grams. AKG+ is the only AKG supplement to have 3 grams per dose on the market.
AKG Benefits
-
Inhibits mTOR
-
Increase Collagen production
-
Decrease muscle degradation
-
Reduces bone mineral loss
-
Anti-aging supplement
-
Maintains Gut integrity
-
Fertility benefits (Oocyte health)
Ingredients
• Calcium Alpha Ketoglutarate: 3000mcg
Feel Younger and Stronger with nuBioAge's AKG+
Looking for a natural way to boost your energy, support your muscles, bones, and even promote healthier aging? nuBioAge's AKG+ might just be the secret you're after. Our unique formula is designed to tap into the power of Calcium Alpha-Ketoglutarate (AKG), a key player in your body's energy production process.
What is AKG+?
AKG+ is a dietary supplement that provides a full 3 grams of Alpha-Ketoglutarate per serving—the highest available on the market. AKG is a crucial molecule that helps drive the Krebs cycle, which is your body's way of turning food into the energy you need every day. It's also vital for maintaining the health of your gut and supporting the cells that line your gastrointestinal tract.
Why Choose AKG+?
- Supports Muscle and Bone Health: AKG+ is designed to help decrease muscle breakdown and enhance the formation of bone tissue, keeping you stronger and more active.
- Promotes Youthful Skin: With its ability to increase collagen production, AKG+ can help your skin look firmer and more youthful.
- Aids in Healthy Aging: AKG+ works to inhibit pathways like mTOR, which are associated with aging, helping you maintain vitality as you age.
- Supports Gut Health: By maintaining gut integrity, AKG+ contributes to a healthy digestive system, which is essential for overall well-being.
- Fertility Benefits: For those concerned about reproductive health, AKG+ has been linked to benefits in oocyte (egg cell) health, supporting fertility.
Easy to Use:
Taking AKG+ is simple. Just follow the recommended dose to integrate this powerful supplement into your daily routine and start feeling the benefits.
A Natural Approach to Wellness:
nuBioAge is committed to providing high-quality, natural supplements. AKG+ is a testament to our dedication to your health and longevity. While AKG+ is generally well-tolerated, we always recommend talking to a healthcare professional before starting any new supplement, especially if you have pre-existing health conditions or are pregnant or breastfeeding.
Start Your Journey to a Healthier You:
With nuBioAge's AKG+, you're not just taking a supplement; you're taking a step towards a healthier, more vibrant life. Whether you're looking to support your physical strength, maintain your youthful appearance, or simply invest in your long-term health, AKG+ is here to help you achieve your wellness goals.
Apigenin is a flavonoid with a broad spectrum of biological
activities, including effects on metabolism, inflammation,
neuroprotection, and anti-cancer properties. It acts as a potent
inhibitor of CD38, a key enzyme that reduces NAD levels,
thereby influencing several cell signaling pathways.
Apigenin has also been shown to influence
weight, inflammation, and insulin resistance by
altering the gut microbiota and restoring the
richness and diversity of the gut microbiota.
Cellular Pathways
Inhibition of CD38 is the core pathway for
mitigating age related decline. CD38 is the
main enzyme that degrades NAD+.
Why this matters:
CD38 is abundant in inflammatory cells and key in the decline of NAD+, crucial for cell functions. With aging, CD38 expression, mRNA, and NADase activity increase, accelerating cellular aging. Overexpression of CD38 in cancer cells triggers aging-like features. Also, low-grade inflammation during aging boosts CD38 expression in inflammatory cells, leading to their accumulation in tissues, indicating CD38’s significant role in the cycle of aging and inflammation.
CD38 Degrades NAD+ Precursors: Implications for NAD+ Replacement Therapy
• CD38 is required for the age related NAD decline and mitochondrial dysfunction via a pathway mediated at least in part by regulation of the SIRT3 activity
• NAD replacement-based therapies with NMN and NR for metabolic dysfunction could be significantly improved by combination with CD38 inhibitors.
Synergy with NAD precursors, Guttides, Leusynergy:
Apigenin™ + (NMN, NR, 5-amino, NAD injection)
Apigenin in conjunction with NAD precursors like NMN, NR, 5-amino1mq and NAD injections create a systematic approach to cellular efficiency.
Apigenin™ + (Guttides, Larazotide, nuButyrate™)
Due to Apigenin effects on the microbiome and akkermensia it is commonly added to gut health protocol using Guttides, Larazotide and butryrate.
Apigenin™ + (GLP-1, Sermorelin, Leusynergy™, Sytrinol® LNA)
Apigenin is also used in combination with peptides and supplements that improve metabolism such as GLP-1s and Sermorelin.
30 CAPSULES
SERVING SIZE: 1
DIRECTIONS: Take 1 capsule daily
Amount Per Serving
Apigenin - 150mg
Cellulose (Capsule)
Rice Flour
Magnesium Stearate
Daily Value (DV) not established
Showing 14/14