About Life Extension
Life Extension is a privately owned vitamin and supplement company founded in 1980 and headquartered in Fort Lauderdale, Florida.
The brand offers a broad range of science-based supplements, vitamins, minerals, antioxidants, probiotics, specialty formulas, and wellness products across many health categories.
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Fight both abdominal & overall fat
AMPK is an enzyme found in every cell in your body. Studies show that increasing AMPK activity can encourage cells to stop storing fat and start burning it for energy—but AMPK levels decline over time.
What Is AMPK Metabolic Activator?
AMPK Metabolic Activator is our customer-favorite formula for weight management. It contains 450 mg of G. pentaphyllum (Jiaogulan) extract and 500 mg of hesperidin, a flavonoid derived from citrus fruit. Each bottle contains 30 vegetarian tablets, enough for a one-month supply at the suggested dosing of one tablet a day. AMPK Metabolic activator is gluten-free and made with 100% NON-GMO ingredients.
The G. pentaphyllum in our formula has been clinically studied to reduce stubborn abdominal fat—and we’ve augmented it with hesperidin from citrus fruit.
AMPK Metabolic Activator Benefits
- Fight fat by encouraging cellular AMPK enzyme activity
- Targets stubborn abdominal fat with G. pentaphyllum extract
- Helps fight overall body fat with the citrus flavonoid hesperidin
Targeting both Belly & Overall Fat
Abdominal fat is one of the worst types of fat. That’s where AMPK Metabolic Activator comes in: not only does the hesperidin citrus extract target overall body fat, but the G. pentaphyllum extract has been clinically studied to target abdominal fat, the type of adipose tissue we’re all trying to avoid.
Fat can accelerate the aging process in your body. Reduced AMPK activity has been observed in fat tissue. That’s where promoting AMPK enzyme activity comes in.
Increasing AMPK activity
Increasing AMPK enzyme activity tells cells to stop storing fat and start using it to create ATP.4 Your body uses ATP for cellular energy. And our AMPK Metabolic Activator provides the citrus flavonoid hesperidin to support overall fat reduction and Actiponin® G. pentaphyllum extract, an extract that activates AMPK and helps promote abdominal fat reduction.
Healthy cellular AMPK activity is an essential part of a weight management program. But please note: AMPK activation will be more effective when combined with a healthy diet and regular exercise.
Other health benefits of hesperidin
Hesperidin also helps promotes healthy vascular function. Try AMPK Metabolic Activator and take the fight against belly fat to the cellular level.
Actiponin® is a trademark of TG Biotech Co., Ltd. Dosage and Use
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- When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.
This formula provides the milk thistle benefits of silymarin, silibinins and isosilybin A and B, as well as phospholipids to aid absorption. These compounds deliver full-spectrum support for liver health.
Healthy liver, healthy body
Modern living puts a heavy load on the liver, making it critical to proactively maintain liver health. That’s where hepato-protective herbs such as milk thistle come in. Milk thistle contains antioxidants that support not only liver health, but overall health.1-3
Silymarin is extracted from milk thistle. This extract is a powerful free radical scavenger that promotes healthy liver function in its own right.4-10 Advanced extraction technology has now allowed us to isolate other constituents within the silymarin extract itself and test their ability to support liver health and beyond.
Other compounds in our milk thistle extract
Silibinin is another compound present in our high-quality milk thistle extract. Made up of silybins A and B, it is the most biologically active flavonolignan component found in milk thistle extract. Its beneficial effects on the liver have been shown in pre-clinical and clinical studies. Other milk thistle extracts called isosilybin A and B have proven to be the most efficient at helping to maintaining healthy cell division.
Phosphatidylcholine and other phospholipids enhance milk thistle’s delivery
The main bioactive compound of milk thistle, called silybin, does not dissolve well in water. This makes it difficult for the body to absorb all of it. Scientists have overcome silybin’s poor bioavailability by integrating it into a phytosome. A phytosome is a tiny sphere made out of plant-derived phosphatidylcholine.
This phosphatidylcholine-based delivery system facilitates transportation across the intestinal lining into the bloodstream, making it an ideal carrier molecule for silybin. Scientists believe that phosphatidylcholine molecularly bonds to silybin, helping to steer it through the cell membranes in the intestinal tract. This improves the delivery of the benefits of milk thistle extracts for liver health.
Preclinical and clinical evidence showed that this silybin-phosphatidylcholine complex resulted in almost 5-fold greater concentrations of silybin in the bloodstream than unformulated silymarin, and its ultimate bioavailability to the liver, its target organ, is up to 10-fold greater than unformulated silymarin.
SILIPHOS® is a registered trademark of Indena S.p.A., Italy. Contains Soybeans |
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- KEEP OUT OF REACH OF CHILDREN
- DO NOT EXCEED RECOMMENDED DOSE
- Do not purchase if outer seal is broken or damaged.
- When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.
Melatonin releases from the pineal gland, reaching its peak at night to help maintain healthy cell health throughout the body.82 Secretion of melatonin declines significantly with age, as the pineal gland becomes calcified.83 Jet lag, shift work, and poor vision can disrupt melatonin cycles.84-86
Melatonin keeps our circadian cycle in tune.87, 88 Not only does this hormone work to maintain cell health, it appears to regulate a system of self-repair and regeneration.89-94 As melatonin diminishes with age, our biological functions are impaired.95, 96 Melatonin also has strong antioxidant properties. It directly scavenges both hydroxyl and peroxyl free radicals, and it does so more effectively than most other antioxidants. It also greatly potentiates the efficiency of other endogenous and exogenous antioxidants.97 Melatonin is especially important for protecting cellular DNA against peroxynitrite damage by inhibiting peroxynitrite free radical reactions.98 Some research has found that melatonin increases the speed of falling asleep and adds to the quality of sleep in about 60% of people who use it.99-102
References available upon request.
- Dissolve one (1) lozenge under the tongue and swallow 30-60 minutes before bedtime, or as recommended by a healthcare practitioner.
- Use an additional lozenge if needed for sleep.
Serving Size: 1 vegetarian lozenge
Amount Per Serving
Melatonin ... 3mg
Other ingredients: sorbitol, microcrystalline cellulose, croscarmellose sodium, vegetable stearate.
Non-GMO
Caution
Consult your healthcare provider before taking this product if you are being treated for a medical condition (especially autoimmune or depressive disorders). Use caution if combining with alcohol. This product is not intended for children, pregnant or lactating women, or women trying to become pregnant. Do not attempt to drive or operate heavy machinery after taking this product.
Warnings
- KEEP OUT OF REACH OF CHILDREN
- DO NOT EXCEED RECOMMENDED DOSE
- Do not purchase if outer seal is broken or damaged
L-Methylfolate 8500 mcg DFE, 30 vegetarian tablets
Heart & brain health, homocysteine support, strong dose
Our High Potency Optimized Folate is a cardiovascular health supplement that also supports cognitive health and more with 8500 mcg of metabolically active 5-MTHF.
What is High Potency Optimized Folate?
Maintaining normal levels of homocysteine, a metabolic byproduct, is associated with both cardiovascular and cognitive health. Folate, a B vitamin, helps maintain homocysteine levels already within normal range. However, not everyone can efficiently convert folate to its biologically active form. Our formula provides 5-MTHF, so you don’t have to.
The 5-MTHF folate in High Potency Optimized Folate is an ultra-bioavailable form of the B-vitamin commonly called folic acid.
High Potency Optimized Folate Benefits
- Super high-potency dose of bioavailable 5-MTHF folate
- Supports both cardiovascular & cognitive health
- Helps maintain already-healthy homocysteine levels
- 5-MTHF folate overcomes the enzyme inefficiency roadblock
For the Greatest Health Benefits
Folic acid is a common B-vitamin supplement. Once ingested, your body is supposed to convert folic acid into 5-methyltetrahydrofolate, or 5-MTHF. But research shows that many people lack sufficient activity of the enzyme that’s necessary to do this. So we formulated High Potency Optimized Folate with 8500 mcg of 5-MTHF, saving your body the trouble.
Folic acid is the most common form of folate supplements. Once ingested, your body is supposed to convert folic acid, a synthetic version of folate, into 5-methyltetrahydrofolate, or 5-MTHF. But research shows that many people lack sufficient activity of the enzyme that's necessary to convert folic acid to 5-MTHF.1-3 A more useful approach is to take 5-MTHF directly.4-6
5-MTHF, homocysteine & cardiovascular health
Folate helps maintain healthy homocysteine levels already within the normal range. By helping to inhibit excess homocysteine, folate supports healthy levels of this important cardiovascular health biomarker.1 And 5-MTHF has been shown to be more bioavailable than folic acid in some studies.5,7
5-MTHF, homocysteine & cognitive health
5-MTHF's greater bioavailability is especially important for people who don't have enough activity of the enzyme necessary to convert folic acid to its biologically active form. Since people with elevated homocysteine levels have a greater risk of cognitive decline, the increased efficiency of 5-MTHF in supporting healthy folate status is especially crucial for aging individuals. 8,9
Take alone or with B12 for enhanced effect
The RDA for folate for non-pregnant or lactating adults is 400 mcg a day, but this high-potency formula provides 8500 mcg of this super-bioavailable form of folate. For even greater health benefits, take 5-MTHF folate with methylcobalamin (the active form of vitamin B12), vitamin B6 and/or riboflavin.
°DFE (dietary folate equivalents) Non-GMO |
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Consult your healthcare provider if you are at risk of vitamin B12 deficiency, as high-dose folate may mask signs. |
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- KEEP OUT OF REACH OF CHILDREN
- DO NOT EXCEED RECOMMENDED DOSE
- Do not purchase if outer seal is broken or damaged.
- When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.
Helps reduce the appearance of wrinkles, for plant-based diets
Finally: a vegan alternative to support healthy collagen production. Our formula delivers a clinically studied blend of amino acids, vitamin C and botanical ingredients to support healthy collagen production in the body.
What is Vegan Pro-Collagen?
Many collagen supplements aren’t compatible with a plant-based diet. But now there’s a vegan alternative: Vegan Pro Collagen combines the same amino acid profile as type I collagen (the most common type of collagen found in skin) with vitamin C, gotu kola and ginseng root extracts, in a combination clinically studied to promote healthy collagen production and help reduce common signs of skin aging and the appearance of wrinkles.
Do you follow a vegan or vegetarian diet? This formula is the perfect way to support healthy collagen production and radiant skin.
Vegan Pro Collagen Benefits
- Clinically studied to reduce the appearance of wrinkles by 14%, enhance skin texture by 13%, and increase collagen density by 8% after just eight weeks
- Delivers the identical amino acid “building blocks” that your body can use to create type I collagen
- Contains an additional botanical blend to help support normal collagen production and nourish youthful, vibrant looking skin
- Provides a vegan alternative to popular collagen supplements
A Vegan Alternative for Healthy Collagen Production
You don’t have to choose between a plant-based lifestyle and beautiful skin. Vegan Pro Collagen combines the exact amino acid profile as the type I collagen in your skin with vitamin C, gotu kola and ginseng root extracts. This combination has been clinically studied to support healthy collagen production and healthy-looking skin and reduce the appearance of wrinkles.
Our Vegan Pro Collagen is a novel alternative to traditional collagen supplements, ideal for those following plant-based diets. Here's why: the nutrient blend in our formula has been scientifically formulated to provide the same skin benefits as other collagen supplements.
Clinical studies
During pilot randomized, placebo-controlled studies, the amino acids and collagen-boosting nutrients in our Vegan Pro Collagen supplement were taken for four weeks. The vegan collagen group recorded an increase in collagen density and an improvement in the appearance of fine lines and wrinkles. In the second study, the vegan collagen group noted improvements in skin texture and hydration.
In another double-blind, placebo-controlled study, our vegan collagen combo was compared to traditional collagen (from fish). Not only did the vegan collagen group report similar improvements in collagen density, appearance of wrinkles, and overall skin hydration and health, but the vegan collagen group's results were nearly identical to the marine collagen group.
Non-GMO |
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- KEEP OUT OF REACH OF CHILDREN
- DO NOT EXCEED RECOMMENDED DOSE
- Do not purchase if outer seal is broken or damaged.
- When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.
Circulation, vascular health, nitric oxide production
Support healthy nitric oxide production and overall vascular health with NitroVasc™ Boost. This formula contains a long-lasting form of L-arginine, which stays in the blood longer than regular arginine.
*Not a low-calorie food.
Gluten free Non-GMO Sugar free* Vegetarian
What Is NitroVasc Boost?
Nitric oxide is produced by your vascular endothelium—the delicate inner lining of your arteries and veins. Encouraging nitric oxide production promotes optimal circulation and helps maintain healthy blood flow. L-arginine is a popular supplement because it encourages nitric oxide production. Plus, this novel L-arginine-silicon complex lasts longer in your bloodstream than standard L-arginine supplements, making it a great choice for promoting vascular health.
Next stop, heart health: the long-lasting L-arginine in NitroVasc™ Boost encourages nitric oxide production—and with it, circulatory health.
NitroVasc™ Boost Benefits
- Encourages nitric oxide production
- Promotes blood flow & circulatory health
- Helps maintain endothelial & arterial health
- Lasts longer in the bloodstream than standard L-arginine
- Berry-flavored powder mixes easily with water
Here's to Your Vascular Health
Nitric oxide promotes vasodilation, or the widening of your blood vessels and veins. This in turn encourages everything from circulatory health to overall cardiovascular function. But your body uses up the nitric oxide that your endothelial cells produce very quickly. To prolong the production of nitric oxide, NitroVasc™ Boost contains a special arginine-silicon complex that lasts longer in your bloodstream than standard L-arginine formulations—which gives your body more time to make use of it.
Why Should I Supplement With NitroVasc™ Boost?
Stay on the highway to heart health with NitroVasc™ Boost.
The delicate linings of your blood vessels produce nitric oxide, which in turn promotes healthy blood flow and circulation. But your body uses up that nitric oxide very quickly. NitroVasc™ Boost is formulated with a special L-arginine silicate complex that stays in the blood longer than regular arginine so your heart can stay the course. The sugar-free, berry-flavored powder mixes easily with water, and it's great before or after your workout.
So get ready to live life at full speed with NitroVasc™ Boost from Life Extension.
FAQ
How does NitroVasc™ Boost work?
NitroVasc™ Boost is intended to promote heart health by supporting circulation and healthy nitric oxide levels. Nitric oxide, a compound produced by your blood vessels, is important for triggering dilation for healthy blood flow and supports circulation. NitroVasc™ Boost helps maintain optimal nitric oxide production through a bioavailable form of L-arginine (the body uses arginine to make nitric oxide) stabilized with inositol that lasts up to six hours in the body.
What is in NitroVasc™ Boost?
NitroVasc™ Boost contains 1500 mg of a trademarked form of arginine stabilized with inositol for greater absorption and longer lasting benefits.
Who is NitroVasc™ Boost intended for?
NitroVasc™ Boost is best suited for those who are looking to encourage their overall cardiovascular health through support of healthy nitric oxide levels and flow-mediated dilation, a measure of healthy endothelial function and blood flow.
How is this reformulation different from the original NitroVasc™ Boost?
We have improved the taste of this product while keeping it berry flavored, and it now comes in a tub instead of individual stick packs. Aronia has been removed from this new and improved formula to improve the flavor of the product.
Is NitroVasc™ Boost flavored? Does this product contain sugar?
NitroVasc™ Boost is berry flavored using natural flavors. This product is sweetened with the compound rebaudioside A from stevia extract and is sugar-free*.
*Not a low calorie food.
When can I expect an effect?
You may experience initial effects in as little as one day! In a study of people who took the arginine-silicate complex used in NitroVasc™ Boost, higher plasma levels of arginine were reported within 30 minutes and lasted up to six hours, as compared to those taking standard arginine (whose effects lasted less than four hours).
After 14 days of use, morning nitric oxide measurements before product use trended higher in the arginine-silicate group, as compared to their day 1 baseline levels.
However, everybody is unique, so the time it takes to notice benefits can vary from person to person.
Can I take this product with other heart health products?
Yes, this product can be taken with other heart health products as part of a comprehensive cardiovascular health regimen.
When is the best time to take NitroVasc™ Boost? Should it be taken with food or on an empty stomach?
This product can be taken any time of day on an empty stomach. We suggest mixing 1 scoop of NitroVasc™ Boost powder in 8-12 ounces of water or any beverage of choice.
Will this supplement interact with my medication?
There is no indication that the nutrients within this formula would negatively interact with prescription medications. However, we always suggest that you inform your physician of any supplements you are taking.
Has this product been tested for heavy metals, contaminants, and potency?
All our raw materials and finished products go through stringent testing to meet our high-quality standards. Testing is performed for heavy metals, microbes, dissolution, potency, and quantity of active ingredients in the finished product. Only when finished products meet Life Extension’s specifications are they released for production. A finished product Certificate of Analysis (COA) can be provided upon request for all our products.
Are there any major allergens in this product?
NitroVasc™ Boost does not contain any of the 9 major allergens required on the label under the Food Allergy Safety, Treatment, Education, and Research (FASTER) Act. This means it is free of milk, eggs, fish, crustacean shellfish, tree nuts, peanuts, wheat, sesame and soybeans.
Where is this product manufactured?
NitroVasc™ Boost is manufactured in the USA in a GMP-compliant facility.
Is this product vegetarian?
Yes, this product is vegetarian and does not contain any animal-derived ingredients.
Is this product gluten free?
Yes, this product is gluten free.
Is this product non-GMO?
Yes, Life Extension has verified that this product and all its ingredients are non-GMO.
Can children take this product?
This product was designed for adults over 18. Always consult with your child’s pediatrician before giving them any supplements.
Your vascular endothelium produces nitric oxide, which in turn promotes blood flow and circulatory health. But endothelial nitric oxide production declines over time. We formulated NitroVasc™ Boost to promote nitric oxide production and support endothelial health.1,2
An L-arginine formula with staying power
L-arginine is an amino acid that can be made into nitric oxide by the enzyme nitric oxide synthase in the endothelium and elsewhere.3 This enzyme encourages nitric oxide production and helps support healthy circulation. But regular L-arginine doesn’t stay in your blood very long.4
That’s why our formulators chose Nitrosigine®, an innovative complex of the amino acid L-arginine and silicate: it stays in the bloodstream longer than standard arginine preparations, making it a great choice for promoting vascular health.4,5
Clinical research studies
In a randomized, placebo-controlled trial, a one-time dose of this arginine-silicate complex helped maintain flow-mediated dilation—a process used to measure circulatory health.2
During a different randomized, double-blind, placebo-controlled study, healthy volunteers took 1,500 mg a day of arginine-silicate complex directly before exercise for four days. For the group taking the arginine-silicate combo, salivary nitric oxide scores were significantly higher post-exercise than those taking the placebo.1
NitroVasc™ Boost vs. regular arginine supplements
Many popular arginine supplements use a form of this amino acid called arginine hydrochloride. A randomized, double-blind trial showed that this form doesn’t provide the same blood plasma concentrations of L-arginine as the L-arginine-silicate complex in NitroVasc™ Boost:
Participants got either arginine hydrochloride or the arginine-silicate complex. The arginine-silicate group measured statistically significant improvements in plasma arginine (that’s arginine levels in the blood) one, two, three and even six hours after ingestion, while the arginine hydrochloride group only showed a blood-arginine boost for the first hour.4
Berry-flavored powder
NitroVasc™ Boost comes in a berry-flavored powder for convenient use in pre- or post-workout drink mixes, protein shakes or your favorite beverage. Each scoop delivers approximately 1,500 mg of this arginine-silicate combo, an equal or greater amount taken than in the above studies.
Non-GMO Nitrosigine® is a registered trademark of Nutrition 21, LLC. Nitrosigine® is patent protected. |
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- KEEP OUT OF REACH OF CHILDREN
- DO NOT EXCEED RECOMMENDED DOSE
- Do not purchase if outer seal is broken or damaged.
- When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.
For bladder health and normal urinary frequency
Need a break from bathroom breaks? This formula combines horsetail, lindera, and three-leaf caper extracts to support bladder health and maintain healthy urinary frequency for women—day and night.
What is Women's Bladder Support?
Many women need a little help when it comes to bladder and urinary health—especially as they get older. The three-herb blend of horsetail, lindera and three-leaf caper extracts can help maintain bladder comfort and normal urinary frequency—with women reporting positive results in a recent clinical study.
A healthy bladder puts you in control! Women’s Bladder Support helps you maintain bladder health and healthy urinary frequency.
Women’s Bladder Support
- Specially formulated bladder health supplement for women
- Herbal supplement made with lindera, three-leaf caper and horsetail extracts
- Helps maintain normal urinary frequency & nighttime urination patterns
- Women reported significant bladder relief during human trials
A Science-Backed Way to Support Bladder Health
There are plenty of anecdotal recipes for bladder health out there—but this horsetail, lindera, and three-leaf caper combo is backed by science. In a clinical study including over 80 women, those taking the combination reported better bladder comfort, as well as better ability to maintain healthy urinary patterns.
If you don’t want to spend your golden years in the ladies’ room, maintaining bladder and urinary health is key. So be proactive with this bladder health supplement for women, which can help keep your bladder healthy and supports normal urinary frequency.
In a recent clinical study including over 80 women, the herbal blend of horsetail, lindera and three-leaf caper extracts was shown to help support bladder muscle health, normal urinary frequency, better bladder comfort, as well as better ability to maintain healthy urination patterns.
What’s in Women’s Bladder Support?
The three herbal extracts work together to help support healthy bladder and normal urinary frequency.
In a preclinical study, this three-extract combo was shown to:
- Support bladder epithelium and muscle health, which promotes bladder comfort
- Calm the part of your brain that gets you up when you need to go
Stay in control when nature calls—add Women’s Bladder Support to your wellness routine.
Non-GMO Urox® and Cratevox™ are trademarks of Seipel Group Pty Ltd. US Patent No’s 9,452,191; 11,110,141. |
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- KEEP OUT OF REACH OF CHILDREN
- DO NOT EXCEED RECOMMENDED DOSE
- Do not purchase if outer seal is broken or damaged.
- When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.
Promotes healthy fluid balance
Our Venotone supplement combats water retention and supports healthy fluid balance & optimal vascular function with horse chestnut seed extract.
What Is Venotone?
Water retention can lead to occasional leg discomfort. Scientific studies on escin, a bioactive compound found in horse chestnut, have shown its veno-protective properties and its ability to help combat water retention. This horse chestnut seed extract contains escin to help maintain healthy vascular function and promote healthy fluid balance.
Venotone supports normal vascular function and helps protect veins using escin.
Venotone Benefits
- Supports healthy vascular function
- Combats water retention
- Promotes leg comfort
- Provides veno-protective properties
Science-Backed Supplements
Escin has been clinically studied and revealed to have properties that promote optimal vascular health. By researching the ingredients we use, we ensure that you are getting the high-quality, effective nutritional support you need.
Horse chestnut contains bioactive compounds called escin. Studies have shown that escin has veno-protective properties and can combat water retention.
Evidence from clinical trials supports the use of horse chestnut seed extract to support sufficient venous function and support leg comfort.
Venotone is an extract of horse chestnut, which has been standardized to escin.
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- KEEP OUT OF REACH OF CHILDREN
- DO NOT EXCEED RECOMMENDED DOSE
- Do not purchase if outer seal is broken or damaged.
- When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.
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