Life Extension

Optimized Carnitine provides three advanced forms of carnitine to optimize cellular energy production for a healthy heart, brain, and exercise recovery.

Benefits at a Glance:

• Optimizes cellular energy production and availability
• Promotes brain and hearth health
• Supports youthful exercise recovery

Carnitine is an amino derivative found in nearly every cell of the body that transports fatty acids to the mitochondria to be used as fuel for energy production. These three novel forms of carnitine work synergistically to get your mitochondria to produce cellular energy fast and efficiently. This boost in cellular function helps to combat the age-related decrease in cellular energy, and is essential for your brain, heart, and exercise recovery.

Acetyl-L-Carnitine

This is the form of carnitine that is chiefly involved in moving fat molecules across the mitochondrial membrane.1 It crosses into the brain from the bloodstream and provides additional energy directly to brain cells.

• Brain Function: Most studies of neurodegeneration use the acetyl-carnitine form. Research has demonstrated improvements in memory and learning as well as mental status and cognitive function.2-6
• Mood Support: Acetyl-L-carnitine enhances the release of dopamine (the “feel good” neurotransmitter) from neurons and helps it bind to dopamine receptors.7, 8 Various studies have exhibited its ability to stabilize and improve mood.9, 10

Acetyl-L-Carnitine Arginate

Acetyl-L-Carnitine Arginate (ACA) is molecularly bonded to the amino acid arginine. ACA induces the outgrowth of the tiny but essential nerve cell protrusions called neurites that underpin memory formation and learning.11

Propionyl-L-Carnitine

Research has shown that Propionyl-L-Carnitine (PLC) plays an important role in protecting the function and health of endothelial cells.12-14 It has shown to help correct an imbalance between the production and utilization of adenosine triphosphate (ATP), the energy currency used throughout the body. This suggests that PLC may optimize cardiac performance by enhancing energy metabolism and increasing ATP levels.15
In addition to protecting vascular cells from damage, PLC optimizes endothelial function by increasing the production of vaso-dilating nitric oxide.16

As a result of its mechanisms of action, PLC can help improve physical performance, male sexual function, and general fatigue.17-19

Optimized Carnitine provides three advanced forms of carnitine combined into a single formula. All three of these powerful forms of carnitine work together to help your body recover quicker from exercise and support your heart, brain, and nervous system health all at the same time!

References

1. J Neurochem. 2010 Aug;114(3):820-31.
2. Rejuvenation Res. 2011 Dec;14(6):669-79.
3. J Alzheimers Dis. 2010;19(2):735-46.
4. Drugs Exp Clin Res. 1994;20(4):169-76.
5. Ann N Y Acad Sci. 2004 Nov;1033:108-16.
6. Int Psychogeriatr. 1998 Jun;10(2):193-203.
7. J Neurosci Res. 1991 Nov;30(3):555-9.
8. Neurochem Res. 1993 May;18(5):573-8.
9. Bipolar Disord. 2002 Feb;4(1):61-6.
10. Eur Neuropsychopharmacol. 2006 May;16(4):281-7.
11. Neurochem Res. 1995 Jan;20(1):1-9.
12. Int J Tissue React. 1991;13(1):41-3.
13. Drugs Exp Clin Res. 1993;19(5):213-7.
14. Int J Tissue React. 1991;13(1):37-40.
15. J Cardiovasc Pharmacol. 1995 Sep;26(3):372-80.
16. Life Sci. 2005 Jun 13.
17. J Am Coll Cardiol. 1995 Nov 15;26(6):1411-16.
18. Urology. 2004 Apr;63(4):641-6.
19. Psychosom Med. 2004 Mar;66(2):276-82.

Take two (2) capsules once or twice daily, or as recommended by a healthcare practitioner. This product can be taken on an empty stomach with water or juice in the morning in divided doses or all at once.

Serving Size: 2 Vegetarian Capsules

Amount Per Serving
Acetyl L-Carnitine HCl ... 800mg
Acetyl L-Carnitine Arginate Di-HCl ... 300mg
Glycine Propionyl L-Carnitine HCl ... 300mg

Other Ingredients: vegetable cellulose (capsule), dicalcium phosphate, stearic acid, silica.

Non-GMO

Warnings

• Keep out of reach of children
• Do not exceed recommended dose.
• Do not purchase if outer seal is broken or damaged.
• When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

Our overall immune system can decline over time, especially the activity of NK cells, your body’s first response to unknown immune challenges. NK Cell Activator™ contains 500 mg of a proprietary blend of modified rice bran to strengthen the activity of NK cells with just a few months of use each year.

NK cell activity provides protection against seasonal immune challenges for real-world immune support.

NK Cell Activator™ Benefits:

• Supports the activity of natural killer cells
• Helps protect against seasonal immune challenges
• Encourages functional activity of natural killer cells to support the immune system

Suggested Use:

Take one (1) tablet one to two times daily with food, or as recommended by a healthcare practitioner.

Serving Size: 1 Vegetarian Tablet

Amount Per Serving

Proprietary Enzymatically Modified Rice Bran … 500 mg

Other ingredients: microcrystalline cellulose, maltodextrin, dicalcium phosphate, croscarmellose sodium, stearic acid, silica, hydroxypropyl cellulose, coating (hydroxypropyl methylcellulose, glycerin), vegetable stearate.

Contains wheat.

Gluten free - Non-GMO - Vegetarian

Warnings

• KEEP OUT OF REACH OF CHILDREN
• DO NOT EXCEED RECOMMENDED DOSE
• Do not purchase if outer seal is broken or damaged.
• When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

Vitamin B12 is present in foods of animal origin, including dairy products and eggs. Thus, vegetarians are more susceptible to a dietary deficiency of this important nutrient.1 Likewise, vitamin B12 serum concentrations are reported to be significantly lower in elderly population groups compared to younger groups.2-6 It is estimated that 10% to 30% of individuals over the age of 50 have low stomach acid secretion7, 8 which results in decreased bioavailability of vitamin B12 from food.

Methylcobalamin is the form of vitamin B12 active in the central nervous system. It is essential for cell growth and replication.8 In some people the liver may not convert cyanocobalamin, the common supplemental form of vitamin B12, into adequate amounts of methylcobalamin needed for proper neuronal functioning.9 Methylcobalamin may exert its neuroprotective effects through enhanced methylation, acceleration of nerve cell growth, or its ability to maintain already healthy homocysteine levels.10, 11

References
1. Exp Biol Med (Maywood). 2007 Nov;232(10):1266-74.
2. Am J Clin Nutr. 2009 Feb;89(2):693S-6S
3. Prev Med. 2004 Dec;39(6):1256-66.
4. Am J Clin Nutr. 1999;70:904-910.
5. Am J Clin Nutr. 2008 Aug;88(2):348-55.
6. JAMA. 1997 Aug 27;278(8):659-62.
7. J Am Geriatr Soc. 1986 Nov;34(11):800-6.
8. Br J Haematol. 2010 Jan;148(2):195-204.
9. Baillieres Clin Haematol. 1995 Sep;8(3):567-601.
10. Pol Merkur Lekarski. 2010 Mar;28(165):236-8.
11. Eur J Clin Nutr. 2010 May;64(5):495-502

Dissolve in mouth or chew one (1) lozenge 1 to 8 times daily, or as recommended by a healthcare practitioner.

Serving Size: 1 vegetarian lozenge

Amount Per Serving
Vitamin B12 ... 5mg
(as methylcobalamin)

Other ingredients: xylitol, natural vanilla flavor, sorbitol, stearic acid, tapioca starch, tapioca maltodextrin, vegetable stearate.

Warnings

• KEEP OUT OF REACH OF CHILDREN
• DO NOT EXCEED RECOMMENDED DOSE
• Do not purchase if outer seal is broken or damaged.
• When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.

• KEEP OUT OF REACH OF CHILDREN
• DO NOT EXCEED RECOMMENDED DOSE
• Do not purchase if outer seal is broken or damaged.
• When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

L-cysteine is a conditionally essential amino acid, one of only three sulfur-containing amino acids, the others being taurine (which can be produced from L-cysteine) and L-methionine (from which L-cysteine can be produced in the body by a multi-step process). Cysteine plays a role in the sulfation cycle, acting as a sulfur donor in phase II detoxification and as a methyl donor in the conversion of homocysteine to methionine.1-3 Cysteine also helps synthesize glutathione, the body’s most important intracellular antioxidant and a vital detoxifier.4-7

Glutathione (L-gamma-glutamyl-L-cysteinyl-glycine) is a peptide molecule synthesized in the body from the three amino acids L-glutamic acid, L-cysteine and glycine. Glutathione is one of the body’s most important and powerful antioxidants, 8 helping to detoxify xenobiotics.9-12 A major function of vitamin C is to keep glutathione in its reduced form so that it can continue to provide free radical-quenching effects.13-16

Vitamin C, or ascorbic acid, is a white, crystalline, water-soluble substance found in citrus fruits. As an antioxidant, vitamin C scavenges free radicals in the body and protects tissues from oxidative stress.17-24 Vitamin C also promotes the absorption of iron, while preventing its oxidation.25, 26 Vitamin C is a vital cofactor to the formation of collagen, the connective tissue that supports arterial walls, skin, bones, and teeth.20-22

References available upon request.

Take one (1) capsule one to three times daily on an empty stomach, or as recommended by a healthcare practitioner.

Serving Size: 1 vegetarian capsule

Amount Per Serving
Vitamin C ... 500mg
(as ascorbic acid)
Setria® L-Glutathione ... 50mg
(reduced)
L-Cysteine Hydrochloride ... 200mg

Other ingredients: vegetable cellulose (capsule), rice bran, microcrystalline cellulose, silica.

Non-GMO

Warnings

• KEEP OUT OF REACH OF CHILDREN
• DO NOT EXCEED RECOMMENDED DOSE
• Do not purchase if outer seal is broken or damaged.
• When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

Setria® is a registered trademark of KYOWA HAKKO BIO Co., Ltd.

These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.

Gamma E Mixed Tocopherols & Tocotrienols is an all-natural, oral formula that provides a full spectrum vitamin E for potent antioxidant protection. The term "vitamin E" refers to a family of eight related, lipid-soluble, antioxidant compounds widely present in plants. The tocopherol and tocotrienol subfamilies are each composed of alpha, beta, gamma, and delta fractions having unique biological effects. Gamma E Mixed Tocopherols & Tocotrienols contains the complete spectrum of all eight vitamin E tocopherol and tocotrienol forms.

Benefits at a Glance

• Full spectrum vitamin E
• Potent antioxidant protection
• Provides both members of the vitamin E family — tocopherols and tocotrienols
• Provides the optimal amount and ratio of alpha, beta, gamma, and delta sub-families

Vitamin E is a Family of Antioxidant Compounds

The term "vitamin E" refers to a family of eight related, lipid-soluble, antioxidant compounds widely present in plants. The tocopherol and tocotrienol subfamilies are each composed of alpha, beta, gamma, and delta fractions having unique biological effects.

Different ratios of these compounds are found in different parts of a plant. For example, the green parts of a plant contain mostly alpha tocopherol and the seed germ and bran contain mostly tocotrienols.

Along with other nutrients, tocopherols and tocotrienols are concentrated in the bran layers of the rye grain, and are only present at low levels in the flour endosperm. Tocopherols are also present in algae, mint teas, and other foods.1-4

Vitamin E Provides Potent Antioxidant Benefits

As a family of antioxidant compounds, vitamin E is one of the most researched and most important nutrients to consume daily. One or more members of the vitamin E family may:

• Maintain cell membrane integrity and reduce cellular aging5-7
• Act as a free radical scavenger8-11
• Maintain healthy platelet aggregation12-15
• Promote a healthy nervous system and retina of the eye16-19
• Maintain healthy cognitive function20-25
• Enhance immune function26-29

Gamma Tocopherol is Critically Important

Prestigious scientific journals have highlighted gamma tocopherol as one of the most critically important forms of vitamin E for those seeking optimal health benefits. In fact, studies show the combination of alpha- and gamma-tocopherol supplementation appears to be superior to either supplementation alone on biomarkers of oxidative stress and on inflammatory factors.30, 31

Most commercial vitamin E supplements contain little, if any, gamma tocopherol. They instead rely on alpha tocopherol as the primary ingredient. However, it is gamma tocopherol (not the alpha form) that quenches peroxynitrite, the free radical that plays a major role in the development of age-related decline.32

Tocotrienols Support Arteries and Nerves

Tocotrienols have shown superior action in maintaining arterial health.33-36 In 2010, a team of Asian scientists demonstrated that this class of nutrients, which are difficult to obtain in sufficient quantities through dietary sources alone, may provide superior support in maintaining triglyceride levels already within healthy range in aging individuals.

Just 120 mg per day of gamma-delta tocotrienols (provided in 3-4 softgels) induced a 28% decline in triglyceride levels in the blood after just one month. This wonder nutrient is so effective because of its structure of double bonds in the isoprenoid side chain, making it a great scavenger of free radicals.37

Research has shown that tocotrienols display potent neuroprotective properties and in particular alpha-tocotrienol is being touted as the most potent neuroprotective form of vitamin E.38-42

References

1. Take one (1) softgel once or twice daily with food, or as recommended by a healthcare practitioner.

   The natural separation of active ingredients may occur.

   
   

   Serving Size: 1 softgel

   Amount Per Serving
   Vitamin E ... 45IU
   (as D-alpha tocopherol)
   Gamma E mixed tocopherols ... 360mg
   Typical distribution:
   Gamma tocopherol 178-244 mg
   Delta tocopherol 65-98 mg
   Alpha tocopherol 27-39 mg
   Beta tocopherol <16 mg
   Mixed tocotrienols/tocopherol complex ... 145mg
   Typical distribution:
   Gamma tocotrienol 25-34 mg
   Alpha tocotrienol 17-22 mg
   Delta tocotrienol 10-15 mg
   Beta tocotrienol 2 mg
   Alpha tocopherol 13-19 mg

   Other Ingredients: gelatin, glycerin, medium chain triglycerides oil, purified water, sunflower oil, rosemary extract.

   Non-GMO

   Tocotrienols are extracted and concentrated from sustainably sourced Malaysian red palm oil.

   
   

   Caution
   If you are taking anti-coagulant or anti-platelet medications, or have a bleeding disorder, consult your healthcare provider before taking this product.

   Warnings

   • KEEP OUT OF REACH OF CHILDREN
   • DO NOT EXCEED RECOMMENDED DOSE
   • Do not purchase if outer seal is broken or damaged.
   • When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

Derived from the ancient medicinal plant Coleus forskohlii, Forskolin’s basic mechanism of action is the activation of an enzyme, adenylate cyclase, which increases cyclic adenosine monophosphate (cAMP) in cells.621 Cyclic AMP is perhaps the most important cell-regulating compound. Once formed, it activates many other enzymes involved in diverse cellular functions.

References available upon request.

Take one (1) capsule daily on an empty stomach, or as recommended by a healthcare practitioner.

Serving Size: 1 vegetarian capsule

Amount Per Serving
Coleus forskohlii extract ... 100mg
(root) [standardized to 10% forskolin (10 mg)]

Other ingredients: rice flour, vegetable cellulose (capsule), maltodextrin, vegetable stearate.

Warnings

• KEEP OUT OF REACH OF CHILDREN
• DO NOT EXCEED RECOMMENDED DOSE
• Do not purchase if outer seal is broken or damaged.
• When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.