About Life Extension
Life Extension is a privately owned vitamin and supplement company founded in 1980 and headquartered in Fort Lauderdale, Florida.
The brand offers a broad range of science-based supplements, vitamins, minerals, antioxidants, probiotics, specialty formulas, and wellness products across many health categories.
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Unlike the water-soluble form, the fat-soluble thiamine (benfotiamine) in our formula easily penetrates cells. It’s been shown to support thiamine levels faster and longer than water-soluble thiamine.
What Is Benfotiamine with Thiamine?
Benfotiamine, a fat-soluble form of vitamin B1 (thiamine), supports healthy blood sugar metabolism and helps encourage the body’s tissues against advanced glycation end products and oxidative stress.
Benfotiamine is more bioavailable than water-soluble thiamine. It can also easily penetrate the inside of cells.
Benfotiamine with Thiamine Benefits
- Supports healthy blood sugar metabolism
- Promotes optimal thiamine levels important for supporting cardiovascular health
- Helps protect against advanced glycation end products
- Provides support against oxidative stress
Maintain Already Healthy Blood Sugar Levels
Benfotiamine can promote healthy glucose metabolism and blood glucose levels already within normal range. Our Benfotiamine with Thiamine formula is a dietary supplement that can help maintain already-healthy blood sugar levels and support the health of the nerves, kidneys, eyes, blood vessels and heart.
Benfotiamine is a fat-soluble form of vitamin B1 (thiamine). Thiamine is needed for normal blood sugar metabolism via a non-oxygen-dependent metabolic pathway called the pentose phosphate pathway.1,2 The products of this pathway are needed for fatty acid, amino acid and nucleotide synthesis. Adequate levels of thiamine are especially critical to supporting healthy brain function, where cells rely on the pentose phosphate pathway for energy.2 Thiamine also helps encourage the body’s tissues against advanced glycation end products and oxidative stress, making maintaining optimal levels important for supporting cardiovascular and metabolic health.
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- KEEP OUT OF REACH OF CHILDREN
- DO NOT EXCEED RECOMMENDED DOSE
- Do not purchase if outer seal is broken or damaged.
- When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.
What Is L-Lysine?
Lysine, a building block for protein, is an essential amino acid, which means it is not produced by our bodies. Therefore, it has to be obtained through our diet. Lysine helps encourage a healthy stress response and helps inhibit glycation, which can play a role in a variety of age-related factors.
Among its potential health benefits, lysine supplementation has been shown to increase calcium absorption and retention.
L-Lysine Benefits
- Supports healthy nitrogen balance
- Promotes healthy calcium metabolism
- Encourages a healthy stress response
- Helps inhibit glycation
Fight Against Age-Related Factors
Lysine is an essential amino acid necessary for growth, and it helps maintain nitrogen balance in the body. It also appears to inhibit glycation, a biochemical reaction that can contribute to a variety of age-related factors. Glycation events disrupt the normal function of protein and lipid structures in the body and are accelerated by elevated levels of sugar in the blood.
Most people consume adequate amounts of lysine, but vegan diets need to include beans and lentils in order to provide enough.1 Athletes involved in frequent vigorous exercise have an increased need for essential amino acids, and vegan athletes face the greatest challenge in getting the right balance and amounts of dietary amino acids.
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- KEEP OUT OF REACH OF CHILDREN
- DO NOT EXCEED RECOMMENDED DOSE
- Do not purchase if outer seal is broken or damaged.
- When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.
Immune, bone & whole body health, value size
Your skin produces vitamin D when in direct sunlight or indoor tanning devices, but that’s not an ideal solution for obvious reasons. Choose a potent vitamin D3 supplement from Life Extension instead.
What Is Vitamin D3?
Supplementing with vitamin D goes a long way. Vitamin D helps preserve youthful cognitive function, supports bone and immune system health, helps maintain already-healthy blood pressure, encourages a healthy inflammatory response and promotes endothelial function. We recommend between about 125 mcg (5,000 IU) to 200 mcg (8,000 IU) of vitamin D3 a day.
Make sure you’re getting enough of vitamin D3, the sunshine vitamin. Add Vitamin D3 to your supplement regimen today.
Vitamin D3 Benefits
- Helps maintain youthful, healthy cognitive function
- Supports bone health & immune system function
- Promotes cardiovascular & endothelial health
- Helps maintain blood pressure already within the normal range
Getting Enough of the Sunshine Vitamin
Vitamin D is called the sunshine vitamin because your skin manufactures it when exposed to sunlight, but that shouldn’t be your only source. A vitamin D supplement goes a long way. We recommend about 125 mcg (5,000 IU) to 200 mcg (8,000 IU) of vitamin D3 a day. If your multivitamin already delivers 25-75 mcg (1,000–3,000 IU) of vitamin D, vitamin D3 125 mcg (5,000 IU) is perfect for achieving optimal levels.
Maintaining healthy levels of vitamin D helps preserve youthful cognitive function and offers broad-spectrum benefits for bone, immune system health and more. Here's why you should be making sure you get enough of this essential vitamin every day:
Cognitive health
Vitamin D is important for maintaining cognitive health and function as you age. Healthy serum vitamin D levels have been shown to correspond with better scores on cognitive health tests and better maintenance of cognitive ability in aging individuals.
Bone and immune health
Vitamin D (along with vitamin K and essential minerals) is essential for facilitating the transport of calcium into the bone matrix. This is an important step in maintaining strong, healthy bones and teeth. Vitamin D also plays a critical role in healthy immune function.
Heart health & blood pressure support
Vitamin D helps to regulate the body's calcium balance while facilitating calcium absorption into the bloodstream, promotes a healthy inflammatory response in the cardiovascular system and encourages healthy endothelial function.7,8 Vitamin D may also help inhibit excess renin levels. Healthy renin levels help maintain healthy blood pressure already within the normal range.
Getting enough vitamin D
This vitamin D3 supplement delivers 25 mcg (1,000 IU) of vitamin D3 as cholecalciferol per softgel. We suggest that you take a 25-hydroxy vitamin D blood test after 3 months to assess and adjust your dosage. Your optimal blood levels should be 50–80 ng/ml year-round.
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Individuals consuming more than 50 mcg (2000 IU)/day of vitamin D (from diet and supplements) should periodically obtain a serum 25-hydroxy vitamin D measurement. Do not exceed 10000 IU per day unless recommended by your doctor. Vitamin D supplementation is not recommended for individuals with high blood calcium levels. |
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- KEEP OUT OF REACH OF CHILDREN
- DO NOT EXCEED RECOMMENDED DOSE
- Do not purchase if outer seal is broken or damaged.
- When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.
Many B vitamins are used in the body individually or in combination with enzymes to help release energy from carbohydrates, fat, and protein. Vitamin B coenzymes are crucial to the metabolic pathways that generate the energy needed by every cell in the body. Because they are codependent in their metabolic activities, a deficiency of one B vitamin can affect optimal functioning of organ systems throughout the body.170
Niacin is the only B vitamin that can be synthesized in the liver from the amino acid tryptophan — on average, 1 mg of niacin can be synthesized from the ingestion of 60 mg of tryptophan.198-200 In its coenzyme forms, niacin is crucial to energy transfer reactions, particularly the metabolism of glucose, fat, and alcohol.201, 202 Niacin’s beneficial effects on blood lipids is well-documented.203-215
Suggested Use:
Take one (1) capsule daily with meals, or as recommended by a healthcare practitioner.
Serving Size: 1 capsule
Amount Per Serving
Niacin ... 500mg
(vitamin B3)
Other ingredients: gelatin, vegetable stearate.
Non-GMO
Caution:
Temporary flushing, itching, rash, gastric disturbances, lightheadedness, or unexpected drop in blood pressure may occur. Liver function testing is recommended when niacin is taken in excess of 500 mg daily.
Warnings
- KEEP OUT OF REACH OF CHILDREN
- DO NOT EXCEED RECOMMENDED DOSE
- Do not purchase if outer seal is broken or damaged.
- When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.
These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.
Our purrfect nutrient mix for kitty
Everybody has nutritional needs, including your cat. Our high-quality pet supplement for cats provides nutritional support to help keep your pet healthy.
What Is Cat Mix?
Cats have their own nutritional needs to suit their systems, especially since (unlike modern domesticated dogs) they are carnivorous. With this comes many other dietary needs that may not be met by cat food alone. Supplementing your cat’s diet helps ensure that they’re getting enough vital nutrients to maintain overall health.
Your cat may not be getting enough essential nutrients from diet alone. Cat Mix helps maintain optimal nutrition.
Cat Mix Benefits
- Helps promote heart, kidney & eye health with taurine
- Contains arginine to support normal heart, kidney & pancreatic function as well as gut health
- Promotes cardiovascular health with B vitamins
- Encourages optimal health with high-quality ingredients
Premium-Quality Ingredients for All
Life Extension® believes that all customers deserve high-quality nutritional supplements made with premium-quality ingredients. That includes our furry friends. Our pet supplements contain ingredients held to the same standards as the rest of our products to ensure that your pet gets the same nutritional support we give you.
Animals have different physiological and structural systems and therefore need specific food and nutrients to remain in optimal health. Household pets are often considered family members who require special attention. Filling the need, the pet food industry has grown tremendously over the years. But you have to wonder if you are getting enough nutrients for your cat.
Special diet required
Cats have been domesticated since early times to catch rats and mice. Today, they are primarily household pets that, like dogs, require special attention when it comes to nutrition and care. Cats are carnivorous. But unlike dogs that can eat some plant-based foods, cats’ digestive systems are especially equipped to process animal protein.
Nutrients like taurine and arginine are important to a cat’s health. Taurine, for cats, is a must for heart, kidney and eye health. Arginine helps support detoxification of ammonia in cats’ kidneys and is also important for promoting optimal heart and pancreatic function and keeping the gut healthy. Arachidonic acid is an essential fatty acid for cats, since cats cannot convert significant quantities of linoleate to arachidonate. And, just like humans, cats need B vitamins to help support the cardiovascular system.
Cats also have problems metabolizing certain amino acids from other nutrients, like the conversion of niacin from tryptophan, or vitamin A from beta carotene. For that reason, cats have more stringent nutritional requirements than such omnivores as dogs and humans.
More facts about Cat Mix
So how can you be sure that you are giving your pet the best nutrition? Besides high-quality commercial foods that are nutrient-enriched, food supplements are the best way to ensure your pets are getting all the vitamins and minerals they need to live long healthy lives.
Our Cat Mix helps protect your pet’s health. Just two scoops per day provide the vitamins your pet needs to stay healthy and strong. Cat Mix contains significant amounts of high-grade nutrients usually reserved for human supplements. It contains flavonoids, amino acids, antioxidants, probiotics, essential fatty acids, methylation enhancers and more.
In fact, many commercial pet foods do not contain the vitamins, amino acids, phytonutrients and advanced antioxidants found in Cat Mix. Life Extension pet supplements contain the same premium-grade nutrients used in all of our products.
Contains egg, fish (tilapia). †Colony Forming Units at time of manufacture 1 - Betatene® is a registered trademark of BASF SE. |
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This product is not meant to replace veterinary care. Any animal not responding to nutritional therapy should be seen by a licensed, competent veterinarian. Always inform your veterinarian if your animal is taking a supplement. |
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- KEEP OUT OF REACH OF CHILDREN
- DO NOT EXCEED RECOMMENDED DOSE
- Do not purchase if outer seal is broken or damaged
Healthy glucose metabolism, ultra-bioavailable B1, high potency
Benfotiamine, a fat-soluble form of vitamin B1 (thiamine), provides healthy blood sugar metabolism support and helps protect the body’s tissues against advanced glycation end products (AGEs) and oxidative stress.
What Is Mega Benfotiamine?
Mega Benfotiamine is formulated with 250 mg of benfotiamine and 10 mg of thiamine (vitamin B1) to support healthy blood sugar metabolism. It also helps protect your body against oxidative stress and glycation, a biochemical reaction that can contribute to a variety of age-related factors.
Benfotiamine can modulate glucose metabolism and support already-healthy blood glucose levels.
Mega Benfotiamine Benefits
- Helps support healthy blood sugar metabolism
- Supports already-healthy blood glucose levels
- Offers protection against advanced glycation end products (AGEs) & oxidative stress
Benfotiamine Better Than Thiamine?
Benfotiamine may also be more helpful in certain situations than thiamine: for example, the enzyme transketolase is critical to blood sugar metabolism and requires thiamine as a cofactor. Unfortunately, the water-soluble thiamine is less available to the interior of the cell, while benfotiamine is fat-soluble and can easily penetrate the cell membrane.
Benfotiamine, a fat-soluble form of vitamin B1 (thiamine), provides healthy blood sugar metabolism support and helps protect the body’s tissues against advanced glycation end products (AGEs) and oxidative stress.
Benfotiamine is also more bioavailable than the water-soluble thiamine. In a landmark study, benfotiamine effectively increased transketolase activity in cell cultures by an astounding 300%, compared to a mere 20% for thiamine. This robust activation was sufficient to block three of the four major metabolic pathways. Benfotiamine also blocked the activation of the transcription factor known as nuclear factor-kappa B (NF-kB).
Overall, benfotiamine can modulate glucose metabolism and promote healthy blood glucose levels already within the normal range. By doing so, benfotiamine also helps inhibit the formation of AGEs and supports healthy endothelial function.
Non-GMO Dosage and Use
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- KEEP OUT OF REACH OF CHILDREN
- DO NOT EXCEED RECOMMENDED DOSE
- Do not purchase if outer seal is broken or damaged.
- When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.
Immune & cardiovascular health, oxidative stress, bioavailability
Bio-Quercetin® uses a quercetin combined with fibers from fenugreek seeds to increase bioavailability. The result: a science-based quercetin supplement that far outclasses standard quercetin formulations.
What Is Bio-Quercetin?
Quercetin encourages heart health and supports a healthy immune response. But like many phytonutrients, quercetin isn’t easy to absorb. So we combined quercetin with fenugreek seed fibers to enhance "free" quercetin up to 18x (with up to 62x better total bioavailability) over standard quercetin formulas.
Looking for a quercetin supplement? Take the one that’s up to 62x more bioavailable. Now that’s a healthy decision!
Bio-Quercetin® Benefits
- Delivers 18x more bioavailable free quercetin (up to 62x better total bioavailability)*
- Promotes immune, cardiovascular & endothelial health
- Helps protect against oxidative stress & supports a healthy inflammatory response
*Than unformulated quercetin formulas
Why Should I Supplement With Bio-Quercetin?
- Encourage healthy cellular function
- Support cardiovascular & endothelial health
- Quercetin inhibits oxidative stress & helps promote a healthy inflammatory response
Clinically Studied for Greater Bioavailability
In a randomized clinical study, researchers compared the formulated Bio-Quercetin to unformulated quercetin. They found that the quercetin formulated with fenugreek fibers led to serum levels of total quercetin up to 62 times higher than unformulated quercetin, and 18 times higher levels of free (unconjugated) quercetin.1
Supports cardiovascular and endothelial health
Quercetin promotes both cardiovascular and endothelial health and helps maintain healthy blood pressure already within the normal range. Quercetin is also a potent inhibitor of oxidative stress and helps promote a healthy inflammatory response.
Promotes a Healthy Immune Response
Quercetin promotes a healthy immune response in the face of seasonal immune challenges. In a randomized clinical trial, quercetin encouraged a healthy immune response in physically fit older adults.
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- KEEP OUT OF REACH OF CHILDREN
- DO NOT EXCEED RECOMMENDED DOSE
- Do not purchase if outer seal is broken or damaged.
- When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.
Digestive comfort, histamine metabolism support
Cheers to digestive comfort! If you experience occasional gas and stomach upset, as well as other gastrointestinal discomforts when enjoying wine, cured meats, cheese, fermented foods or citrus, you may have a sensitivity to dietary histamine. (Note: this is not the same as a food allergy.) Our formula helps you make friends with your food again by supporting the healthy breakdown of intestinal histamine to encourage gastrointestinal comfort.
What is Food Sensitivity Relief* with Diamine Oxidase (DAO)?
Digestive comfort may not always be on the menu when we pair a glass of wine (or beer) with snacks like cured meats, cheeses, citrus and fermented foods. Food Sensitivity Relief with Diamine Oxidase is formulated to help relieve occasional non-allergy digestive discomfort associated with dietary histamine sensitivity.
Make friends with your favorite foods again by encouraging healthy metabolism of histamine-rich foods like cured meats, cheeses and wine.
Food Sensitivity Relief with Diamine Oxidase
- Helps alleviate occasional gas and stomach upset, as well as other gastrointestinal discomforts
- Supports histamine metabolism for digestive comfort
- Provides support for when you snack on histamine-rich foods and drinks like cured meats, cheeses, wine
How to Stay Comfortable After You Eat
Cured meats, cheeses, wine, and other histamine-rich foods make for a delicious charcuterie board, but not everyone can digest these treats comfortably. Our plant-based DAO formula helps relieve occasional non-allergy digestive discomfort associated with intestinal dietary histamine sensitivity. One more thing: many DAO formulas utilize enzymes derived from animals—usually pork. But our formula uses diamine oxidase from pea sprouts. It’s got the same capacity to break down histamine as animal-based DAO…no pork bellies required.
What is a food sensitivity?
Short answer: a food sensitivity is when the body responds to compounds in the food you eat. A food sensitivity (sometimes referred to as a food intolerance) can cause occasional gastrointestinal discomfort, and is often difficult to identify. A food sensitivity is not an allergic reaction.
That said, non-allergy food sensitivities are more common than you think: currently, almost 20% of the Westernized world’s population experience some type of food intolerance.1 Histamine is a compound found in many foods and drinks that has been associated with food sensitivity.
Histamine is a compound found in many foods and drinks that has been associated with food sensitivity such as occasional gas, stomach upset, as well as other gastrointestinal discomforts.
Diamine oxidase in clinical studies
Diamine oxidase (DAO) is the main enzyme that supports the healthy breakdown of intestinal histamine and encourages gastrointestinal comfort.
In a randomized clinical trial, participants who took dietary DAO supplementation 20 minutes before a main meal for eight weeks reported relief from occasional gastrointestinal discomfort.
Research also points to the effectiveness of DAO supplements in inhibiting the incidence and intensity of discomfort due to occasional food sensitivity associated with intestinal dietary histamine sensitivity.
Plant-derived DAO
Many sources of supplementary DAO are derived from pig kidneys. But our formula provides pea sprouts derived DAO with equivalent capacity to break down histamine as used in clinical studies.
Make friends with your favorite foods again with Food Sensitivity Relief with Diamine Oxidase (DAO)!
FAQ
What is histamine?
Histamine is a compound that plays a role in the body’s immune response. It is released in the body and can be produced by gut bacteria. Histamine can also be found in or increased by many foods and drinks. Excessive levels of histamine in the gut can cause occasional gastrointestinal-related discomfort including gas and bloating. The body has several enzymes that help break down this compound.
What types of foods are considered histamine-rich?
Histamine-rich foods and drinks are very common. Some of these include cured and deli meats, different types of cheese, alcoholic beverages like wine and beer, oily fish and even certain fruits and vegetables like citrus, tomatoes and strawberries.
Is histamine sensitivity considered an allergy?
No, histamine sensitivities are considered a sensitivity to histamine ingested from foods. Food sensitivities are the body’s response to compounds in the food you eat, sometimes referred to as food intolerances. Sensitivities are not considered to be the same as an allergic reaction. They may manifest in the form of occasional gastrointestinal discomforts.
Does this product break down whole-body histamine?
No, this product is only intended to help support the breakdown of intestinal histamine associated with non-allergy histamine-food sensitivity.
What is diamine oxidase (DAO)?
Diamine oxidase (DAO) is an enzyme produced by the body that breaks down histamine and is the primary way the body metabolizes histamine in the GI tract. Its activity is measured in HDU, or histamine degrading units. It can be more difficult for people with low levels of DAO to maintain a healthy balance of histamine.
What is in Food Sensitivity Relief with Diamine Oxidase (DAO)?
Food Sensitivity Relief with Diamine Oxidase contains 20,000 HDU of the enzyme diamine oxidase (DAO), derived from pea sprouts. HDU stands for histamine degrading units and is a measure of enzyme activity.
Who is Food Sensitivity Relief with Diamine Oxidase intended for?
Food Sensitivity Relief with Diamine Oxidase is intended for those who need help breaking down and metabolizing histamine in the gut and alleviating occasional discomforts associated with dietary histamine sensitivity.
When can I expect an effect?
In a study of people who took DAO immediately after eating histamine-rich foods, benefits were seen immediately. More long-term effects were observed after taking DAO daily for 4-8 weeks. Everybody is unique, however, so the time it takes to notice benefits can vary from person to person. We suggest following the study duration to determine product efficacy.
When is the best time to take Food Sensitivity Relief with Diamine Oxidase? Should it be taken with food or on an empty stomach?
We suggest taking one capsule before your heaviest meals, up to three times daily.
Will this supplement interact with my medication?
There is no indication that the nutrient in this formula would negatively interact with prescription medications. However, we always suggest that you inform your physician of any supplements you are taking.
Are there any cautions associated with this product?
Food Sensitivity Relief with Diamine Oxidase contains the following caution: This product breaks down histamine but won’t prevent severe allergic or gluten-related (celiac) reactions. Do not knowingly ingest food you are allergic to.
Has this product been tested for heavy metals, contaminants and potency?
All our raw materials and finished products go through stringent testing to meet our high-quality standards. Testing is performed for heavy metals, microbes, disintegration, potency, and quantity of active ingredients in the finished product. Only when finished products meet Life Extension’s specifications are they released for production. A finished product Certificate of Analysis (COA) can be provided upon request for all our products.
Are there any major allergens in this product?
Food Sensitivity Relief with Diamine Oxidase does not contain any of the 9 major allergens required on the label under the Food Allergy Safety, Treatment, Education, and Research (FASTER) Act. This means it is free of milk, eggs, fish, crustacean shellfish, tree nuts, peanuts, wheat, sesame and soybeans.
Where is this product manufactured?
Food Sensitivity Relief with Diamine Oxidase is manufactured in the USA in a GMP-compliant facility.
Is this product vegetarian?
Yes, this product is vegetarian and does not contain any animal-derived ingredients.
Is this product gluten-free?
Yes, this product is gluten-free.
Is this product non-GMO?
Yes, this product and all its ingredients are Life Extension verified non-GMO.
Can children take this product?
No. This product was designed for adults over 18. Always consult with your child’s pediatrician before giving them any supplements.
Non-GMO
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This product breaks down histamine but won’t prevent severe allergic or gluten-related (celiac) reactions. Do not knowingly ingest food you are allergic to. |
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- KEEP OUT OF REACH OF CHILDREN
- DO NOT EXCEED RECOMMENDED DOSE
- Do not purchase if outer seal is broken or damaged.
- When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.
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