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MegaSporeBiotic capsules Microbiome Labs
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MegaSporeBiotic™ – 100% Spore-Based Probiotic for Gut Reconditioning, Capsules
Microbiome Labs
Clinically Proven. Spore-Powered. Microbiome Reconditioning Starts Here.
MegaSporeBiotic™ is the first clinically studied, 100% spore-based probiotic supplement designed to recondition the gut microbiome, support gut barrier integrity, and promote immune homeostasis. Unlike conventional probiotics that often die before reaching the intestines, spore-forming Bacillus strains in MegaSporeBiotic™ are naturally equipped to survive digestion, colonize the gut, and restore microbial balance.
This flagship product of Microbiome Labs is shelf-stable, effective at a low dose (4 Billion CFU), and does not require refrigeration.
Key Benefits
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Clinically shown to recondition the gut and support microbial diversity
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Promotes gut lining repair and intestinal barrier integrity
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Supports immune modulation and inflammatory balance
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Enhances production of short-chain fatty acids (SCFAs), especially butyrate
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Helps maintain levels of beneficial commensal bacteria
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Survives heat, stomach acid, and bile — no refrigeration needed
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Part of the Total Gut Restoration system by Microbiome Labs
Science Behind the Strains
Each 2-capsule serving delivers 4 Billion CFU of five synergistic, spore-forming Bacillus strains:
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Bacillus indicus HU36™ – Produces antioxidants (lycopene, astaxanthin, beta-carotene) at the site of absorption
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Bacillus subtilis HU58™ – Supports immune modulation, gut lining, and vitamin K2 production
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Bacillus coagulans SC208 – Enhances protein digestion and metabolic support
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Bacillus licheniformis SL307 – Promotes mucosal immunity and digestive balance
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Bacillus clausii SC109 – Resistant to antibiotics; helps regulate immune and respiratory health
These strains are clinically validated and selected for their ability to support keystone gut species and SCFA production — both essential for optimal health.
Supplement Facts
Serving Size: 2 capsules
Servings Per Container: 30
Probiotic Content: 4 Billion CFU
Total Active Blend: 295 mg
Strain | Function |
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Bacillus indicus HU36™ | Antioxidant production |
Bacillus subtilis HU58™ | Immune & gut barrier support |
Bacillus coagulans SC208 | Digestion & motility |
Bacillus licheniformis SL307 | Mucosal balance |
Bacillus clausii SC109 | Immune regulation |
Other Ingredients: Cellulose, vegetable capsule (cellulose and water)
Free from: dairy, gluten, soy, GMOs, artificial colors or preservatives
Suggested Use
Ages 5+:
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Week 1: Take 1 capsule every other day
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Week 2: Take 1 capsule daily
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Week 3 onward: Take 2 capsules daily
Children under 5: Use only under medical supervision.
Can be taken with or without food. No refrigeration required.
Frequently Asked Questions (FAQ)
Q: What makes MegaSporeBiotic™ different from regular probiotics?
A: It contains only spore-based Bacillus strains, which survive digestion, colonize the gut, and recondition the microbiome — unlike typical Lactobacillus or Bifidobacterium strains that often degrade in the stomach.
Q: Is 4 Billion CFU enough?
A: Yes. Spore-based probiotics are highly potent. Clinical trials show 4 Billion CFU is effective for gut restoration and immune modulation.
Q: Can I take it with antibiotics?
A: Yes. Unlike many probiotics, Bacillus spores are resistant to most antibiotics, making this an excellent companion during or after antibiotic use.
Q: Should I take this with food?
A: It can be taken with or without food, but some people prefer taking it with meals for better tolerance during the initial adjustment period.