Pregnenolone 50 mg 60 tablets Allergy Research Group

Product Description

Pregnenolone 50 mg is a micronized, bioavailable form of this neurosteroid and hormone precursor to support mood, stress resilience, and the synthesis of key hormones like cortisol, progesterone, and estrogen.

Micronized pregnenolone to support cognitive function, mood, stress resilience, and healthy hormone synthesis.

What It Does
Pregnenolone is a neurosteroid and hormone precursor that plays a vital role in the production of cortisol, progesterone, estrogen, testosterone, and other steroid hormones. It may support mood, focus, and the body’s adaptive response to stress as levels decline with age.*

How It Works
• Pregnenolone (Micronized): A bioavailable form of the parent steroid hormone that supports adrenal, reproductive, and neurological function.*[1]
• Neurosteroid Activity: Synthesized in the brain and peripheral nervous system, pregnenolone modulates GABA and NMDA receptors and influences neuroplasticity via BDNF.*[2,3,4,5]
• Hormone Precursor: Serves as the first step in the synthesis of key hormones including cortisol and sex hormones, influencing metabolism, immune balance, and reproductive health.*[1,6]
• Cognitive and Mood Support: Clinical trials suggest pregnenolone supplementation supports focus, working memory, and mood, particularly in populations under cognitive or emotional strain.*[7,8,9]
• Age-Related Optimization: Endogenous pregnenolone production decreases with age. Pregnenolone supports mental stamina and resilience.*[6,10]
• Clinical Dosing Evidence: Human studies have used 30–500 mg daily to support quality of life, attention, and cognitive performance in certain populations.*[7,8,9]

Who It’s For
Ideal for adults seeking support for healthy mood, cognitive function, or hormonal balance, especially during periods of stress.

Special Features
ARG offers Pregnenolone (micronized) for enhanced bioavailability in 50 mg and 100 mg strength options to accommodate individualized, evidence-informed protocols.

Pregnenolone helps bridge the gap between hormone synthesis and brain health, supporting multiple systems through a foundational neurosteroid pathway.

References
1. Murugan S, et al. J Biol Chem. 2019;294(12):4596–607.
2. Mathis C, et al. Psychopharmacology (Berl). 1994;116(2):201–6.
3. Mathis C, et al. Neuropharmacology. 1996;35(8):1057–64.
4. Pierce SR, et al. Mol Pharmacol. 2022;101(2):68–77.
5. Charalampopoulos I, et al. Ann N Y Acad Sci. 2006;1088:139–52.
6. Vallee M, et al. Brain Res Brain Res Rev. 2001;37(1–3):301–12.
7. Naylor JC, et al. JAMA Netw Open. 2020;3(3):e200287. doi:10.1001/jamanetworkopen.2020.0287
8. Kreinin A, et al. Clin Schizophr Relat Psychoses. 2017;10(4):201–10.
9. Ritsner MS, et al. J Clin Psychiatry. 2010;71(10):1351–62.
10. Naert G, et al. Psychoneuroendocrinology. 2007;32(8–10):1062–78.